PCSK9 induces a pro-inflammatory response in macrophages

• Published in: Scientific reports Vol. 8; no. 1; pp. 2267 - 10
• Main Authors: Ricci, Chiara, Ruscica, Massimiliano, Camera, Marina, Rossetti, Laura, Macchi, Chiara, Colciago, Alessandra, Zanotti, Ilaria, Lupo, Maria Giovanna, Adorni, Maria Pia, Cicero, Arrigo F. G., Fogacci, Federica, Corsini, Alberto, Ferri, Nicola
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.02.2018; Nature Publishing Group
• Subjects: 13; 13/1; 13/106; 13/21; 14/19; 38/77; 631/80; 692/4019/592/75/593/2100; Animals; Arteriosclerosis; Atherogenesis; Bone marrow; Cell culture; Cell proliferation; Cells, Cultured; Cholesterol; Coculture Techniques; Cytokines; Cytokines - metabolism; Female; Humanities and Social Sciences; Humans; Inflammation; Interleukin 6; Low density lipoprotein; Macrophages; Macrophages - immunology; Male; Mice; mRNA; multidisciplinary; Plasma; Plasma levels; Proprotein Convertase 9 - metabolism; Proteins; Science; Science (multidisciplinary); Smooth muscle; Tumor necrosis factor-TNF; Tumor necrosis factor-α

Intraplaque release of inflammatory cytokines from macrophages is implicated in atherogenesis by inducing the proliferation and migration of media smooth muscle cells (SMCs). PCSK9 is present and released by SMCs within the atherosclerotic plaque but its function is still unknown. In the present stu...