Compressed sensing acceleration of cardiac cine imaging allows reliable and reproducible assessment of volumetric and functional parameters of the left and right atrium

• Published in: European radiology Vol. 31; no. 10; pp. 7219 - 7230
• Main Authors: Altmann, Sebastian, Halfmann, Moritz C., Abidoye, Ibukun, Yacoub, Basel, Schmidt, Michaela, Wenzel, Philip, Forman, Christoph, Schoepf, U. Joseph, Xiong, Fei, Dueber, Christoph, Kreitner, Karl-Friedrich, Varga-Szemes, Akos, Emrich, Tilman
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2021; Springer Nature B.V
• Subjects: Acceleration; Atria; Cardiac; Congestive heart failure; Diagnostic Radiology; Emptying; Evaluation; Heart Atria - diagnostic imaging; Heart Failure; Humans; Image Interpretation, Computer-Assisted; Image quality; Imaging; Internal Medicine; Interventional Radiology; Magnetic Resonance Imaging, Cine; Medical imaging; Medicine; Medicine & Public Health; Neuroradiology; Parameters; Patients; Radiology; Reduction; Reproducibility of Results; Sequences; Stroke Volume; Ultrasound; Heart failure; Atrial function; Magnetic resonance imaging; Heart atria
• ISSN: 0938-7994; 1432-1084; 1432-1084
• DOI: 10.1007/s00330-021-07830-z

Objectives To compare volumetric and functional parameters of the atria derived from highly accelerated compressed sensing (CS)–based cine sequences in comparison to conventional (Conv) cine imaging. Methods CS and Conv cine sequences were acquired in 101 subjects (82 healthy volunteers (HV) and 19 patients with heart failure with reduced ejection fraction (HFrEF)) using a 3T MR scanner in this single-center study. Time-volume analysis of the left (LA) and right atria (RA) were performed in both sequences to evaluate atrial volumes and function (total, passive, and active emptying fraction). Inter-sequence and inter- and intra-reader agreement were analyzed using correlation, intraclass correlation (ICC), and Bland-Altman analysis. Results CS-based cine imaging led to a 69% reduction of acquisition time. There was significant difference in atrial parameters between CS and Conv cine, e.g., LA minimal volume (LAVmin) (Conv 24.0 ml (16.7–32.7), CS 25.7 ml (19.2–35.2), p  < 0.0001) or passive emptying fraction (PEF) (Conv 53.9% (46.7–58.4), CS 49.0% (42.0–54.1), p  < 0.0001). However, there was high correlation between the techniques, yielding good to excellent ICC (0.76–0.99) and small mean of differences in Bland-Altman analysis (e.g. LAVmin − 2.0 ml, PEF 3.3%). Measurements showed high inter- (ICC > 0.958) and intra-rater (ICC > 0.934) agreement for both techniques. CS-based parameters (PEF AUC = 0.965, LAVmin AUC = 0.864) showed equivalent diagnostic ability compared to Conv cine imaging (PEF AUC = 0.989, LAVmin AUC = 0.859) to differentiate between HV and HFrEF. Conclusion Atrial volumetric and functional evaluation using CS cine imaging is feasible with relevant reduction of acquisition time, therefore strengthening the role of CS in clinical CMR for atrial imaging. Key Points • Reliable assessment of atrial volumes and function based on compressed sensing cine imaging is feasible. • Compressed sensing reduces scan time and has the potential to overcome obstacles of conventional cine imaging. • No significant differences for subjective image quality, inter- and intra-rater agreement, and ability to differentiate healthy volunteers and heart failure patients were detected between conventional and compressed sensing cine imaging.