Brain motor and fear circuits regulate leukocytes during acute stress

• Published in: Nature (London) Vol. 607; no. 7919; pp. 578 - 584
• Main Authors: Poller, Wolfram C., Downey, Jeffrey, Mooslechner, Agnes A., Khan, Nargis, Li, Long, Chan, Christopher T., McAlpine, Cameron S., Xu, Chunliang, Kahles, Florian, He, Shun, Janssen, Henrike, Mindur, John E., Singh, Sumnima, Kiss, Máté G., Alonso-Herranz, Laura, Iwamoto, Yoshiko, Kohler, Rainer H., Wong, Lai Ping, Chetal, Kashish, Russo, Scott J., Sadreyev, Ruslan I., Weissleder, Ralph, Nahrendorf, Matthias, Frenette, Paul S., Divangahi, Maziar, Swirski, Filip K.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.07.2022; Nature Publishing Group
• Subjects: 13; 13/1; 13/31; 13/44; 14; 14/1; 14/34; 14/35; 14/63; 59; 631/250/371; 631/378/2607; 631/378/371; Animals; Autoimmunity; Bone marrow; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Brain; Brain - cytology; Brain - physiology; Chemokines; Chemokines - immunology; Circuits; Corticotropin-releasing hormone; COVID-19 - immunology; Disease Susceptibility; Fear - physiology; Genetics; Glucocorticoids; Glucocorticoids - metabolism; Humanities and Social Sciences; Humans; Hypothalamus; Immune response; Immune system; Immunity; Influenza; Information processing; Innate immunity; Leukocytes; Leukocytes (neutrophilic); Leukocytes - cytology; Leukocytes - immunology; Lymphocytes; Lymphocytes - cytology; Lymphocytes - immunology; Lymphoid Tissue - cytology; Lymphoid Tissue - immunology; Mice; Monocytes; Monocytes - cytology; Monocytes - immunology; Motor Neurons - cytology; Motor Neurons - physiology; multidisciplinary; Muscles; Nervous system; Neural Pathways; Neurons; Neutrophils; Neutrophils - cytology; Neutrophils - immunology; Optics; Optogenetics; Organs; Orthomyxoviridae Infections - immunology; Paraventricular Hypothalamic Nucleus - physiology; Psychological stress; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Signal transduction; Skeletal muscle; Stress, Psychological - immunology; Stress, Psychological - physiopathology; Viral diseases

The nervous and immune systems are intricately linked 1 . Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly understood 2 . Here we show that distinct brain regions shape leukocyte distr...