Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

• Published in: Haematologica (Roma) Vol. 105; no. 5; pp. 1285 - 1293
• Main Authors: Yu, Chuanjiang, Gorantla, Sivahari P, Müller-Rudorf, Alina, Müller, Tony A, Kreutmair, Stefanie, Albers, Corinna, Jakob, Lena, Lippert, Lena J, Yue, Zhenyu, Engelhardt, Monika, Follo, Marie, Zeiser, Robert, Huber, Tobias B, Duyster, Justus, Illert, Anna L
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.05.2020
• Subjects: Animals; Autophagy; Beclin-1 - genetics; Fusion Proteins, bcr-abl - genetics; Fusion Proteins, bcr-abl - metabolism; Humans; Imatinib Mesylate - pharmacology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Mice; Phosphorylation

Autophagy is a genetically regulated process of adaptation to metabolic stress and was recently shown to be involved in the treatment response of chronic myeloid leukemia (CML). However, data are limited and the molecular mechanism of autophagy regulators in the process of leukemogenesis is not comp...