Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls

• Published in: Scientific reports Vol. 12; no. 1; pp. 8239 - 11
• Main Authors: Ness, Henning O., Ljones, Kristine, Gjelsvik, Randi H., Tjønna, Arnt Erik, Malmo, Vegard, Nilsen, Hans Olav, Hollekim-Strand, Siri Marte, Dalen, Håvard, Høydal, Morten Andre
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443; 631/443/592/75; 692/308; 692/4019; 692/4019/592; Acute effects; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diastole - physiology; Echocardiography; EKG; Exercise; Exercise Test; Heart rate; Humanities and Social Sciences; Humans; multidisciplinary; NCT; NCT02998008; Oxygen uptake; Physical training; Pilot Projects; Science; Science (multidisciplinary); Training; Velocity; Ventricle; Ventricular Function, Left - physiology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-12375-2

This study evaluated acute cardiac stress after a high-intensity interval training session in patients with type 2 diabetes (T2D) versus healthy controls. High intensity aerobic exercise was performed by 4 × 4-min intervals (90–95% of maximal heart rate), followed by a ramp protocol to peak oxygen uptake. Echocardiography was performed before and 30 min after exercise. Holter electrocardiography monitored heart rhythms 24 h before, during, and 24 h after the exercise. Left atrial end-systolic volume, peak early diastolic mitral annular velocity, and the ratio of peak early to late diastolic mitral inflow velocity were reduced by approximately 18%, 15%, and 31%, respectively, after exercise across groups. Left ventricular end-diastolic wall thickness was the only echo parameter that significantly differed between groups in response to exercise. The T2D group had a rate of supraventricular extrasystoles per hour that was 265% greater than that of the controls before exercise, which remained higher after exercise. A single exhaustive exercise session impaired left ventricular diastolic function in both groups. The findings also indicated impaired right ventricular function in patients with T2D after exercise. ClinicalTrials.gov Identifier: NCT02998008.