Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 3; pp. 1003 - 1008
• Main Authors: Ohnishi, Naomi, Yuasa, Hitomi, Tanaka, Shinya, Sawa, Hirofumi, Miura, Motohiro, Matsui, Atsushi, Higashi, Hideaki, Musashi, Manabu, Iwabuchi, Kazuya, Suzuki, Misao, Yamada, Gen, Azuma, Takeshi, Hatakeyama, Masanori
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.01.2008; National Acad Sciences
• Subjects: Adenocarcinoma; Animals; Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Bacteria; Bacterial proteins; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological Sciences; Bone marrow cells; carcinogenesis; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Epithelial cells; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - metabolism; Gastrointestinal Neoplasms - pathology; Gene expression; Gene Expression Regulation, Neoplastic; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - metabolism; Helicobacter pylori - pathogenicity; Hematologic Neoplasms - genetics; Hematologic Neoplasms - metabolism; Hematologic Neoplasms - pathology; humans; hyperplasia; Hypersensitivity; Infections; Kinases; Leukocytes; Lymphoma; Mice; Mice, Transgenic; Mutation; oncogene proteins; Phosphorylation; phosphotransferases (kinases); Phosphotyrosine - metabolism; polyps (pathological conditions); Rodents; small intestine; Stomach; Transgenic animals; Tumors; type IV secretion system; tyrosine

Infection with cagA-positive Helicobacter pylori is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma of B cell origin. The cagA-encoded CagA protein is delivered into gastric epithelial cells via the bacterial type IV secretion system and, upon tyr...