Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility - Liu, Xiaobo; Zhao, Yingjie; Shi, Huan; Zhang, Yan; Yin, Xueying; Liu, Mingdong; Zhang, Huihui; He, Yongning; Lu, Boxun; Jin, Tengchuan; Li, Fubin (Nature communications, 2019)
Keywords: 13/106; 13/31; 631/250/2152/2153/1291; 631/61/338/469; 631/61/51/1568; 631/67/1059/2325; 64; 64/60; 82/1; 82/83; 9/10; Animals; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Anticancer properties; Binding; Cancer immunotherapy; CD40 antigen; CD40 Antigens - immunology; Divergence; Flexibility; Humanities and Social Sciences; Humans; Immunoglobulin Fc Fragments - immunology; Immunoglobulin Fc Fragments - metabolism; Immunoglobulin G; Immunoglobulin G - immunology; Immunoglobulins; Immunostimulation; Immunotherapy - methods; Mice, Knockout; Mice, Transgenic; multidisciplinary; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - therapy; Protein Binding; Receptors, IgG - agonists; Receptors, IgG - genetics; Receptors, IgG - immunology; Rigidity; Science; Science (multidisciplinary); Synergism