FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion

• Published in: Cell death & disease Vol. 14; no. 1; pp. 13 - 17
• Main Authors: Shao, Wenjun, Li, Jiawei, Piao, Qianling, Yao, Xinlei, Li, Mingyue, Wang, Shuyue, Song, Zhenbo, Sun, Ying, Zheng, Lihua, Wang, Guannan, Liu, Lei, Yu, Chunlei, Huang, Yanxin, Bao, Yongli, Sun, Luguo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.01.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 101/28; 13/106; 13/31; 13/51; 45/29; 59/5; 631/67/1347; 631/80/84/2027; 64/60; 82/80; 96/95; Antibodies; Biochemistry; Biomarkers; Biomedical and Life Sciences; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Biology; Cell Culture; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Cytology; Cytoskeleton; Degradation; Female; Focal Adhesions - metabolism; Gene Expression Regulation, Neoplastic; Humans; Immunology; Life Sciences; Medical prognosis; Metastases; Metastasis; Molecular modelling; Proteasomes; Therapeutic targets; Tumor suppressor genes; Tumor Suppressor Proteins - metabolism; Tumors; Ubiquitin; Ubiquitin - metabolism; Ubiquitin-protein ligase; Ubiquitination; Vimentin; Vimentin - metabolism; Xenografts

Recurrence and metastasis are the main causes of breast cancer (BRCA)-related death and remain a challenge for treatment. In-depth research on the molecular mechanisms underlying BRCA progression has been an important basis for developing precise biomarkers and therapy targets for early prediction a...