The malate sensing two-component system MaeKR is a non-canonical class of sensory complex for C4-dicarboxylates
Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component signal transduction systems (TCS). Here, an example of TCS plasticity is presented: the regulation of L-malate catabolism via malic enzyme by Mae...
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Published in | Scientific reports Vol. 7; no. 1; pp. 2708 - 16 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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02.06.2017
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Abstract | Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component signal transduction systems (TCS). Here, an example of TCS plasticity is presented: the regulation of L-malate catabolism via malic enzyme by MaeRK in
Lactobacillales
. MaeKR belongs to the citrate family of TCS as the
Escherichia coli
DcuSR system. We show that the
Lactobacillus casei
histidine-kinase MaeK is defective in autophosphorylation activity as it lacks a functional catalytic and ATP binding domain. The cognate response regulator MaeR was poorly phosphorylated at its phosphoacceptor Asp
in vitro
. This phosphorylation, however, enhanced MaeR binding
in vitro
to its target sites and it was required for induction of regulated genes
in vivo
. Elucidation of the MaeR structure revealed that response regulator dimerization is accomplished by the swapping of α4-β5-α5 elements between two monomers, generating a phosphoacceptor competent conformation. Sequence and phylogenetic analyses showed that the MaeKR peculiarities are not exclusive to
L. casei
as they are shared by the rest of orthologous systems of
Lactobacillales
. Our results reveal MaeKR as a non-canonical TCS displaying distinctive features: a swapped response regulator and a sensor histidine kinase lacking ATP-dependent kinase activity. |
---|---|
AbstractList | Abstract Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component signal transduction systems (TCS). Here, an example of TCS plasticity is presented: the regulation of L-malate catabolism via malic enzyme by MaeRK in Lactobacillales. MaeKR belongs to the citrate family of TCS as the Escherichia coli DcuSR system. We show that the Lactobacillus casei histidine-kinase MaeK is defective in autophosphorylation activity as it lacks a functional catalytic and ATP binding domain. The cognate response regulator MaeR was poorly phosphorylated at its phosphoacceptor Asp in vitro. This phosphorylation, however, enhanced MaeR binding in vitro to its target sites and it was required for induction of regulated genes in vivo. Elucidation of the MaeR structure revealed that response regulator dimerization is accomplished by the swapping of α4-β5-α5 elements between two monomers, generating a phosphoacceptor competent conformation. Sequence and phylogenetic analyses showed that the MaeKR peculiarities are not exclusive to L. casei as they are shared by the rest of orthologous systems of Lactobacillales. Our results reveal MaeKR as a non-canonical TCS displaying distinctive features: a swapped response regulator and a sensor histidine kinase lacking ATP-dependent kinase activity. Abstract Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component signal transduction systems (TCS). Here, an example of TCS plasticity is presented: the regulation of L-malate catabolism via malic enzyme by MaeRK in Lactobacillales . MaeKR belongs to the citrate family of TCS as the Escherichia coli DcuSR system. We show that the Lactobacillus casei histidine-kinase MaeK is defective in autophosphorylation activity as it lacks a functional catalytic and ATP binding domain. The cognate response regulator MaeR was poorly phosphorylated at its phosphoacceptor Asp in vitro . This phosphorylation, however, enhanced MaeR binding in vitro to its target sites and it was required for induction of regulated genes in vivo . Elucidation of the MaeR structure revealed that response regulator dimerization is accomplished by the swapping of α4-β5-α5 elements between two monomers, generating a phosphoacceptor competent conformation. Sequence and phylogenetic analyses showed that the MaeKR peculiarities are not exclusive to L. casei as they are shared by the rest of orthologous systems of Lactobacillales . Our results reveal MaeKR as a non-canonical TCS displaying distinctive features: a swapped response regulator and a sensor histidine kinase lacking ATP-dependent kinase activity. Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component signal transduction systems (TCS). Here, an example of TCS plasticity is presented: the regulation of L-malate catabolism via malic enzyme by MaeRK in Lactobacillales. MaeKR belongs to the citrate family of TCS as the Escherichia coli DcuSR system. We show that the Lactobacillus casei histidine-kinase MaeK is defective in autophosphorylation activity as it lacks a functional catalytic and ATP binding domain. The cognate response regulator MaeR was poorly phosphorylated at its phosphoacceptor Asp in vitro. This phosphorylation, however, enhanced MaeR binding in vitro to its target sites and it was required for induction of regulated genes in vivo. Elucidation of the MaeR structure revealed that response regulator dimerization is accomplished by the swapping of α4-β5-α5 elements between two monomers, generating a phosphoacceptor competent conformation. Sequence and phylogenetic analyses showed that the MaeKR peculiarities are not exclusive to L. casei as they are shared by the rest of orthologous systems of Lactobacillales. Our results reveal MaeKR as a non-canonical TCS displaying distinctive features: a swapped response regulator and a sensor histidine kinase lacking ATP-dependent kinase activity. Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component signal transduction systems (TCS). Here, an example of TCS plasticity is presented: the regulation of L-malate catabolism via malic enzyme by MaeRK in Lactobacillales . MaeKR belongs to the citrate family of TCS as the Escherichia coli DcuSR system. We show that the Lactobacillus casei histidine-kinase MaeK is defective in autophosphorylation activity as it lacks a functional catalytic and ATP binding domain. The cognate response regulator MaeR was poorly phosphorylated at its phosphoacceptor Asp in vitro . This phosphorylation, however, enhanced MaeR binding in vitro to its target sites and it was required for induction of regulated genes in vivo . Elucidation of the MaeR structure revealed that response regulator dimerization is accomplished by the swapping of α4-β5-α5 elements between two monomers, generating a phosphoacceptor competent conformation. Sequence and phylogenetic analyses showed that the MaeKR peculiarities are not exclusive to L. casei as they are shared by the rest of orthologous systems of Lactobacillales . Our results reveal MaeKR as a non-canonical TCS displaying distinctive features: a swapped response regulator and a sensor histidine kinase lacking ATP-dependent kinase activity. |
ArticleNumber | 2708 |
Author | Monedero, V. Zúñiga, M. Miguel-Romero, L. Casino, P. Marina, A. Landete, J. M. |
Author_xml | – sequence: 1 givenname: L. surname: Miguel-Romero fullname: Miguel-Romero, L. organization: Department of Genomic and Proteomic, Instituto de Biomedicina de Valencia (IBV-CSIC) – sequence: 2 givenname: P. surname: Casino fullname: Casino, P. organization: Departamento de Bioquímica, Universitat de València, Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València – sequence: 3 givenname: J. M. surname: Landete fullname: Landete, J. M. organization: Departamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) – sequence: 4 givenname: V. surname: Monedero fullname: Monedero, V. organization: Departamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC) – sequence: 5 givenname: M. surname: Zúñiga fullname: Zúñiga, M. email: amarina@ibv.csic.es organization: Departamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC) – sequence: 6 givenname: A. surname: Marina fullname: Marina, A. email: btcman@iata.csic.es organization: Department of Genomic and Proteomic, Instituto de Biomedicina de Valencia (IBV-CSIC), Group 739 of the Centro de Investigación Biomédica en Red sobre Enfermedades Raras (CIBERER) del Instituto de Salud Carlos III |
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Cites_doi | 10.1128/MMBR.00001-14 10.1111/j.1365-2958.2011.07829.x 10.1080/10635150390235520 10.1099/mic.0.26257-0 10.1107/S0907444910045749 10.1073/pnas.94.13.6815 10.1111/j.1365-2958.1995.mmi_18030533.x 10.1073/pnas.89.2.718 10.1016/j.jsb.2010.06.008 10.1101/gad.3.11.1725 10.1093/pcp/pcp089 10.1093/nar/gkg565 10.1093/oxfordjournals.molbev.a026334 10.1128/AEM.01177-13 10.1128/JB.00082-10 10.1093/molbev/msw054 10.1038/nmeth.3213 10.1006/jmbi.2000.3595 10.1016/j.sbi.2010.09.010 10.1016/j.mib.2009.12.009 10.1046/j.1365-2958.2000.02055.x 10.1093/bioinformatics/18.1.211 10.1007/BF00590188 10.1093/nar/gku1152 10.1093/nar/gkr245 10.1093/bioinformatics/18.3.502 10.1107/S0907444910007493 10.1128/IAI.02814-14 10.1099/00221287-146-2-263 10.1107/S0907444911001314 10.1128/JB.186.17.5730-5740.2004 10.1128/AEM.02145-09 10.1146/annurev.micro.091208.073214 10.1128/JB.00076-10 10.1016/bs.ampbs.2016.02.003 10.1073/pnas.96.26.14789 10.1038/sj.emboj.7600886 10.1016/S0005-2728(01)00233-X 10.1371/journal.pone.0133389 10.1128/AEM.07280-11 10.1016/j.jmb.2013.12.027 10.1074/jbc.M114.596221 10.1016/j.mib.2010.01.015 10.1107/S0021889807021206 10.1093/bioinformatics/bti263 10.1111/j.1742-4658.2011.08131.x 10.1128/mBio.02105-14 10.1016/S0968-0004(99)01503-0 10.1110/ps.051722805 10.1016/j.cell.2009.08.032 10.1128/JB.00872-15 10.1111/j.1365-2958.2009.06847.x 10.1111/j.1365-2958.2010.07247.x 10.1093/nar/gks485 10.1073/pnas.1013081107 10.1006/jmbi.2000.3598 10.1093/bioinformatics/btu506 10.1128/aem.63.6.2117-2123.1997 10.1128/JB.180.20.5421-5425.1998 10.1107/S0907444907037195 10.1128/JB.00190-07 10.1074/jbc.M705081200 10.1038/ncomms4258 10.1128/JB.00049-07 10.1107/S0907444909047337 10.1128/JB.187.24.8229-8230.2005 10.1016/j.jmb.2016.08.003 |
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References | Deutscher (CR48) 2014; 78 Janausch, Zientz, Tran, Kröger, Unden (CR42) 2002; 1553 Schutz, Radler (CR17) 1974; 96 Castresana (CR59) 2000; 17 Schmidt, Strimmer, Vingron, von Haeseler (CR27) 2002; 18 Dintner, Heermann, Fang, Jung, Gebhard (CR11) 2014; 289 Boc, Diallo, Makarenkov (CR62) 2012; 40 CR36 Lewis (CR45) 2000; 297 Willard (CR56) 2003; 31 Emsley, Lohkamp, Scott, Cowtan (CR54) 2010; 66 CR32 Sakayori, Shiraiwa, Suzuki (CR15) 2009; 50 CR31 Lukat, McCleary, Stock, Stock (CR28) 1992; 89 Marina, Waldburger, Hendrickson (CR25) 2005; 24 Trajtenberg (CR46) 2014; 5 Yang (CR24) 2015; 12 Uchiyama, Mihara, Nishide, Chiba (CR57) 2015; 43 Igo, Ninfa, Stock, Silhavy (CR3) 1989; 3 McCoy (CR52) 2007; 40 Huynh, Noriega, Stewart (CR26) 2010; 107 Di Tommaso (CR58) 2011; 39 Strimmer, von Haeseler (CR63) 1997; 94 Yan (CR30) 1999; 96 CR6 Espariz (CR20) 2011; 278 Zakikhany, Harrington, Nimtz, Hinton, Romling (CR13) 2009; 77 CR47 Yamamoto, Murata, Sekiguchi (CR40) 2000; 37 Gao, Stock (CR1) 2009; 63 Villali, Pontiggia, Clarkson, Hagan, Kern (CR10) 2014; 426 Taylor, Cawley, Hayward (CR33) 2014; 30 Cho (CR9) 2000; 297 Kumar, Stecher, Tamura (CR64) 2016; 33 Casino, Miguel-Romero, Marina (CR2) 2014; 5 Casino, Rubio, Marina (CR5) 2010; 20 Toro-Roman, Wu, Stock (CR35) 2005; 14 Pioszak, Ninfa (CR14) 2010; 186 Casino, Rubio, Marina (CR37) 2009; 139 Bott, Meyer, Dimroth (CR38) 1995; 18 Lobley, Whitmore, Wallace (CR55) 2002; 18 Winn (CR49) 2011; 67 CR51 CR50 Maze (CR65) 2010; 192 Murshudov (CR53) 2011; 67 Leloup, Ehrlich, Zagorec, Morel-Deville (CR67) 1997; 63 Bourret (CR8) 2010; 13 Landete, Ferrer, Monedero, Zuniga (CR19) 2013; 79 Abascal, Zardoya, Posada (CR60) 2005; 21 Guindon, Gascuel (CR61) 2003; 52 Asai, Baik, Kasahara, Moriya, Ogasawara (CR41) 2000; 146 Baker, Satyshur, Moreno Morales, Forest (CR44) 2016; 198 Savitsky (CR66) 2010; 172 Paluscio, Caparon (CR22) 2015; 83 Gao, Stock (CR29) 2010; 13 Zientz, Bongaerts, Unden (CR39) 1998; 180 Ahmad, Cai, Chen, Shuai, Han (CR34) 2015; 10 Tanaka, Kobayashi, Ogasawara (CR43) 2003; 149 Scheu (CR16) 2010; 192 Landete (CR18) 2010; 76 Mortera (CR21) 2012; 78 Dutta, Inouye (CR7) 2000; 25 Huynh, Stewart (CR4) 2011; 82 Tetsch, Jung (CR12) 2014; 73 Unden, Worner, Monzel (CR23) 2016; 68 2900_CR47 GS Lukat (2900_CR28) 1992; 89 GN Murshudov (2900_CR53) 2011; 67 E Paluscio (2900_CR22) 2015; 83 TN Huynh (2900_CR26) 2010; 107 T Sakayori (2900_CR15) 2009; 50 J Villali (2900_CR10) 2014; 426 HA Schmidt (2900_CR27) 2002; 18 IG Janausch (2900_CR42) 2002; 1553 P Emsley (2900_CR54) 2010; 66 L Leloup (2900_CR67) 1997; 63 A Maze (2900_CR65) 2010; 192 P Di Tommaso (2900_CR58) 2011; 39 F Abascal (2900_CR60) 2005; 21 R Gao (2900_CR1) 2009; 63 P Casino (2900_CR37) 2009; 139 L Willard (2900_CR56) 2003; 31 PD Scheu (2900_CR16) 2010; 192 2900_CR6 P Savitsky (2900_CR66) 2010; 172 S Kumar (2900_CR64) 2016; 33 2900_CR36 R Gao (2900_CR29) 2010; 13 S Dintner (2900_CR11) 2014; 289 2900_CR32 2900_CR31 A Lobley (2900_CR55) 2002; 18 H Yamamoto (2900_CR40) 2000; 37 P Casino (2900_CR2) 2014; 5 K Strimmer (2900_CR63) 1997; 94 M Schutz (2900_CR17) 1974; 96 L Tetsch (2900_CR12) 2014; 73 D Taylor (2900_CR33) 2014; 30 D Yan (2900_CR30) 1999; 96 J Yang (2900_CR24) 2015; 12 RJ Lewis (2900_CR45) 2000; 297 A Boc (2900_CR62) 2012; 40 A Marina (2900_CR25) 2005; 24 G Unden (2900_CR23) 2016; 68 J Deutscher (2900_CR48) 2014; 78 R Dutta (2900_CR7) 2000; 25 P Mortera (2900_CR21) 2012; 78 F Trajtenberg (2900_CR46) 2014; 5 I Uchiyama (2900_CR57) 2015; 43 A Toro-Roman (2900_CR35) 2005; 14 AA Pioszak (2900_CR14) 2010; 186 P Casino (2900_CR5) 2010; 20 JM Landete (2900_CR19) 2013; 79 M Bott (2900_CR38) 1995; 18 HS Cho (2900_CR9) 2000; 297 AJ McCoy (2900_CR52) 2007; 40 S Guindon (2900_CR61) 2003; 52 E Zientz (2900_CR39) 1998; 180 TN Huynh (2900_CR4) 2011; 82 RB Bourret (2900_CR8) 2010; 13 A Ahmad (2900_CR34) 2015; 10 K Asai (2900_CR41) 2000; 146 MM Igo (2900_CR3) 1989; 3 2900_CR50 M Espariz (2900_CR20) 2011; 278 2900_CR51 K Zakikhany (2900_CR13) 2009; 77 JM Landete (2900_CR18) 2010; 76 J Castresana (2900_CR59) 2000; 17 MD Winn (2900_CR49) 2011; 67 AW Baker (2900_CR44) 2016; 198 K Tanaka (2900_CR43) 2003; 149 |
References_xml | – volume: 78 start-page: 231 year: 2014 end-page: 256 ident: CR48 article-title: The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions publication-title: Microbiology and Molecular Biology Reviews doi: 10.1128/MMBR.00001-14 contributor: fullname: Deutscher – volume: 82 start-page: 275 year: 2011 end-page: 286 ident: CR4 article-title: Negative control in two-component signal transduction by transmitter phosphatase activity publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2011.07829.x contributor: fullname: Stewart – volume: 52 start-page: 696 year: 2003 end-page: 704 ident: CR61 article-title: A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood publication-title: Systematic Biology doi: 10.1080/10635150390235520 contributor: fullname: Gascuel – volume: 149 start-page: 2317 year: 2003 end-page: 2329 ident: CR43 article-title: The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium publication-title: Microbiology doi: 10.1099/mic.0.26257-0 contributor: fullname: Ogasawara – volume: 67 start-page: 235 year: 2011 end-page: 242 ident: CR49 article-title: Overview of the CCP4 suite and current developments publication-title: Acta Crystallogr D Biol Crystallogr doi: 10.1107/S0907444910045749 contributor: fullname: Winn – volume: 94 start-page: 6815 year: 1997 end-page: 6819 ident: CR63 article-title: Likelihood-mapping: A simple method to visualize phylogenetic content of a sequence alignment publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.94.13.6815 contributor: fullname: von Haeseler – ident: CR51 – volume: 18 start-page: 533 year: 1995 end-page: 546 ident: CR38 article-title: Regulation of anaerobic citrate metabolism in Klebsiella pneumoniae publication-title: Molecular Microbiology doi: 10.1111/j.1365-2958.1995.mmi_18030533.x contributor: fullname: Dimroth – volume: 89 start-page: 718 year: 1992 end-page: 722 ident: CR28 article-title: Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.89.2.718 contributor: fullname: Stock – volume: 172 start-page: 3 year: 2010 end-page: 13 ident: CR66 article-title: High-throughput production of human proteins for crystallization: the SGC experience publication-title: Journal of structural biology doi: 10.1016/j.jsb.2010.06.008 contributor: fullname: Savitsky – volume: 3 start-page: 1725 year: 1989 end-page: 1734 ident: CR3 article-title: Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor publication-title: Genes Dev doi: 10.1101/gad.3.11.1725 contributor: fullname: Silhavy – volume: 50 start-page: 1439 year: 2009 end-page: 1448 ident: CR15 article-title: A Synechocystis homolog of SipA protein, Ssl3451, enhances the activity of the histidine kinase Hik33 publication-title: Plant Cell Physiol doi: 10.1093/pcp/pcp089 contributor: fullname: Suzuki – volume: 31 start-page: 3316 year: 2003 end-page: 3319 ident: CR56 article-title: VADAR: a web server for quantitative evaluation of protein structure quality publication-title: Nucleic Acids Res doi: 10.1093/nar/gkg565 contributor: fullname: Willard – volume: 17 start-page: 540 year: 2000 end-page: 552 ident: CR59 article-title: Selection of Conserved Blocks from Multiple Alignments for Their Use in Phylogenetic Analysis publication-title: Molecular Biology and Evolution doi: 10.1093/oxfordjournals.molbev.a026334 contributor: fullname: Castresana – volume: 63 start-page: 2117 year: 1997 end-page: 2123 ident: CR67 article-title: Single-crossover integration in the Lactobacillus sake chromosome and insertional inactivation of the ptsI and lacL genes publication-title: Appl Environ Microbiol contributor: fullname: Morel-Deville – volume: 79 start-page: 5509 year: 2013 end-page: 5518 ident: CR19 article-title: Malic enzyme and malolactic enzyme pathways are functionally linked but independently regulated in Lactobacillus casei BL23 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.01177-13 contributor: fullname: Zuniga – ident: CR50 – volume: 192 start-page: 3474 year: 2010 end-page: 3483 ident: CR16 article-title: Oligomeric sensor kinase DcuS in the membrane of Escherichia coli and in proteoliposomes: chemical cross-linking and FRET spectroscopy publication-title: J Bacteriol doi: 10.1128/JB.00082-10 contributor: fullname: Scheu – volume: 33 start-page: 1870 year: 2016 end-page: 1874 ident: CR64 article-title: MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets publication-title: Mol Biol Evol doi: 10.1093/molbev/msw054 contributor: fullname: Tamura – volume: 12 start-page: 7 year: 2015 end-page: 8 ident: CR24 article-title: The I-TASSER Suite: protein structure and function prediction publication-title: Nat Methods doi: 10.1038/nmeth.3213 contributor: fullname: Yang – volume: 297 start-page: 543 year: 2000 end-page: 551 ident: CR9 article-title: NMR structure of activated CheY publication-title: J Mol Biol doi: 10.1006/jmbi.2000.3595 contributor: fullname: Cho – volume: 20 start-page: 763 year: 2010 end-page: 771 ident: CR5 article-title: The mechanism of signal transduction by two-component systems publication-title: Curr Opin Struct Biol doi: 10.1016/j.sbi.2010.09.010 contributor: fullname: Marina – ident: CR32 – volume: 13 start-page: 160 year: 2010 end-page: 167 ident: CR29 article-title: Molecular strategies for phosphorylation-mediated regulation of response regulator activity publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2009.12.009 contributor: fullname: Stock – ident: CR36 – volume: 37 start-page: 898 year: 2000 end-page: 912 ident: CR40 article-title: The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis publication-title: Molecular Microbiology doi: 10.1046/j.1365-2958.2000.02055.x contributor: fullname: Sekiguchi – volume: 18 start-page: 211 year: 2002 end-page: 212 ident: CR55 article-title: DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra publication-title: Bioinformatics doi: 10.1093/bioinformatics/18.1.211 contributor: fullname: Wallace – volume: 96 start-page: 329 year: 1974 end-page: 339 ident: CR17 article-title: [The presence of malic enzyme and malo-lactic enzyme in various lactic acid bacteria (author’s transl)] publication-title: Arch Mikrobiol doi: 10.1007/BF00590188 contributor: fullname: Radler – volume: 43 start-page: D270 year: 2015 end-page: D276 ident: CR57 article-title: MBGD update 2015: microbial genome database for flexible ortholog analysis utilizing a diverse set of genomic data publication-title: Nucleic Acids Research doi: 10.1093/nar/gku1152 contributor: fullname: Chiba – volume: 39 start-page: W13 year: 2011 end-page: W17 ident: CR58 article-title: T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension publication-title: Nucleic Acids Research doi: 10.1093/nar/gkr245 contributor: fullname: Di Tommaso – volume: 18 start-page: 502 year: 2002 end-page: 504 ident: CR27 article-title: TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing publication-title: Bioinformatics doi: 10.1093/bioinformatics/18.3.502 contributor: fullname: von Haeseler – volume: 66 start-page: 486 year: 2010 end-page: 501 ident: CR54 article-title: Features and development of Coot publication-title: Acta Crystallogr D Biol Crystallogr doi: 10.1107/S0907444910007493 contributor: fullname: Cowtan – volume: 83 start-page: 1162 year: 2015 end-page: 1171 ident: CR22 article-title: Streptococcus pyogenes malate degradation pathway links pH regulation and virulence publication-title: Infect Immun doi: 10.1128/IAI.02814-14 contributor: fullname: Caparon – volume: 146 start-page: 263 year: 2000 end-page: 271 ident: CR41 article-title: Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis publication-title: Microbiology doi: 10.1099/00221287-146-2-263 contributor: fullname: Ogasawara – volume: 67 start-page: 355 year: 2011 end-page: 367 ident: CR53 article-title: REFMAC5 for the refinement of macromolecular crystal structures publication-title: Acta Crystallogr D Biol Crystallogr doi: 10.1107/S0907444911001314 contributor: fullname: Murshudov – volume: 186 start-page: 5730 year: 2010 end-page: 5740 ident: CR14 article-title: Mutations altering the N-terminal receiver domain of NRI (NtrC) That prevent dephosphorylation by the NRII-PII complex in Escherichia coli publication-title: J Bacteriol doi: 10.1128/JB.186.17.5730-5740.2004 contributor: fullname: Ninfa – volume: 76 start-page: 84 year: 2010 end-page: 95 ident: CR18 article-title: Requirement of the Lactobacillus casei MaeKR two-component system for L-malic acid utilization via a malic enzyme pathway publication-title: Appl Environ Microbiol doi: 10.1128/AEM.02145-09 contributor: fullname: Landete – volume: 63 start-page: 133 year: 2009 end-page: 154 ident: CR1 article-title: Biological insights from structures of two-component proteins publication-title: Annual review of microbiology doi: 10.1146/annurev.micro.091208.073214 contributor: fullname: Stock – ident: CR47 – volume: 180 start-page: 5421 year: 1998 end-page: 5425 ident: CR39 article-title: Fumarate Regulation of Gene Expression in Escherichia coli by the DcuSR (dcuSR Genes) Two-Component Regulatory System publication-title: Journal of Bacteriology contributor: fullname: Unden – volume: 5 start-page: 3258 year: 2014 ident: CR2 article-title: Visualizing autophosphorylation in histidine kinases publication-title: Nat Commun contributor: fullname: Marina – volume: 192 start-page: 2647 year: 2010 end-page: 2648 ident: CR65 article-title: Complete genome sequence of the probiotic Lactobacillus casei strain BL23 publication-title: J Bacteriol doi: 10.1128/JB.00076-10 contributor: fullname: Maze – volume: 68 start-page: 139 year: 2016 end-page: 167 ident: CR23 article-title: Cooperation of Secondary Transporters and Sensor Kinases in Transmembrane Signalling: The DctA/DcuS and DcuB/DcuS Sensor Complexes of Escherichia coli publication-title: Adv Microb Physiol doi: 10.1016/bs.ampbs.2016.02.003 contributor: fullname: Monzel – volume: 96 start-page: 14789 year: 1999 end-page: 14794 ident: CR30 article-title: Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.96.26.14789 contributor: fullname: Yan – volume: 24 start-page: 4247 year: 2005 end-page: 4259 ident: CR25 article-title: Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein publication-title: The EMBO journal doi: 10.1038/sj.emboj.7600886 contributor: fullname: Hendrickson – volume: 1553 start-page: 39 year: 2002 end-page: 56 ident: CR42 article-title: C4-dicarboxylate carriers and sensors in bacteria publication-title: Biochimica et Biophysica Acta (BBA) - Bioenergetics doi: 10.1016/S0005-2728(01)00233-X contributor: fullname: Unden – volume: 10 start-page: e0133389 year: 2015 ident: CR34 article-title: Conformational Dynamics of Response Regulator RegX3 from Mycobacterium tuberculosis publication-title: PLoS One doi: 10.1371/journal.pone.0133389 contributor: fullname: Han – ident: CR6 – volume: 78 start-page: 1936 year: 2012 end-page: 1945 ident: CR21 article-title: Fine-tuned transcriptional regulation of malate operons in Enterococcus faecalis publication-title: Appl Environ Microbiol doi: 10.1128/AEM.07280-11 contributor: fullname: Mortera – volume: 426 start-page: 1554 year: 2014 end-page: 1567 ident: CR10 article-title: Evidence against the “Y-T coupling” mechanism of activation in the response regulator NtrC publication-title: J Mol Biol doi: 10.1016/j.jmb.2013.12.027 contributor: fullname: Kern – volume: 289 start-page: 27899 year: 2014 end-page: 27910 ident: CR11 article-title: A sensory complex consisting of an ATP-binding cassette transporter and a two-component regulatory system controls bacitracin resistance in Bacillus subtilis publication-title: J Biol Chem doi: 10.1074/jbc.M114.596221 contributor: fullname: Gebhard – volume: 13 start-page: 142 year: 2010 end-page: 149 ident: CR8 article-title: Receiver domain structure and function in response regulator proteins publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2010.01.015 contributor: fullname: Bourret – volume: 40 start-page: 658 year: 2007 end-page: 674 ident: CR52 article-title: Phaser crystallographic software publication-title: J Appl Crystallogr doi: 10.1107/S0021889807021206 contributor: fullname: McCoy – volume: 21 start-page: 2104 year: 2005 end-page: 2105 ident: CR60 article-title: ProtTest: selection of best-fit models of protein evolution publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti263 contributor: fullname: Posada – volume: 278 start-page: 2140 year: 2011 end-page: 2151 ident: CR20 article-title: Identification of malic and soluble oxaloacetate decarboxylase enzymes in Enterococcus faecalis publication-title: FEBS J doi: 10.1111/j.1742-4658.2011.08131.x contributor: fullname: Espariz – ident: CR31 – volume: 5 start-page: e02105 year: 2014 ident: CR46 article-title: Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation publication-title: mBio doi: 10.1128/mBio.02105-14 contributor: fullname: Trajtenberg – volume: 25 start-page: 24 year: 2000 end-page: 28 ident: CR7 article-title: GHKL, an emergent ATPase/kinase superfamily publication-title: Trends Biochem Sci doi: 10.1016/S0968-0004(99)01503-0 contributor: fullname: Inouye – volume: 14 start-page: 3077 year: 2005 end-page: 3088 ident: CR35 article-title: A common dimerization interface in bacterial response regulators KdpE and TorR publication-title: Protein Sci doi: 10.1110/ps.051722805 contributor: fullname: Stock – volume: 139 start-page: 325 year: 2009 end-page: 336 ident: CR37 article-title: Structural insight into partner specificity and phosphoryl transfer in two-component signal transduction publication-title: Cell doi: 10.1016/j.cell.2009.08.032 contributor: fullname: Marina – volume: 198 start-page: 1218 year: 2016 end-page: 1229 ident: CR44 article-title: Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction publication-title: J Bacteriol doi: 10.1128/JB.00872-15 contributor: fullname: Forest – volume: 73 start-page: 982 year: 2014 end-page: 991 ident: CR12 article-title: The regulatory interplay between membrane-integrated sensors and transport proteins in bacteria publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2009.06847.x contributor: fullname: Jung – volume: 77 start-page: 771 year: 2009 end-page: 786 ident: CR13 article-title: Unphosphorylated CsgD controls biofilm formation in Salmonella enterica serovar Typhimurium publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2010.07247.x contributor: fullname: Romling – volume: 40 start-page: W573 year: 2012 end-page: W579 ident: CR62 article-title: T-REX: a web server for inferring, validating and visualizing phylogenetic trees and networks publication-title: Nucleic Acids Research doi: 10.1093/nar/gks485 contributor: fullname: Makarenkov – volume: 107 start-page: 21140 year: 2010 end-page: 21145 ident: CR26 article-title: Conserved mechanism for sensor phosphatase control of two-component signaling revealed in the nitrate sensor NarX publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1013081107 contributor: fullname: Stewart – volume: 297 start-page: 757 year: 2000 end-page: 770 ident: CR45 article-title: Domain swapping in the sporulation response regulator Spo0A publication-title: J Mol Biol doi: 10.1006/jmbi.2000.3598 contributor: fullname: Lewis – volume: 30 start-page: 3189 year: 2014 end-page: 3196 ident: CR33 article-title: Quantitative method for the assignment of hinge and shear mechanism in protein domain movements publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu506 contributor: fullname: Hayward – volume: 43 start-page: D270 year: 2015 ident: 2900_CR57 publication-title: Nucleic Acids Research doi: 10.1093/nar/gku1152 contributor: fullname: I Uchiyama – volume: 96 start-page: 14789 year: 1999 ident: 2900_CR30 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.96.26.14789 contributor: fullname: D Yan – volume: 31 start-page: 3316 year: 2003 ident: 2900_CR56 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkg565 contributor: fullname: L Willard – volume: 63 start-page: 2117 year: 1997 ident: 2900_CR67 publication-title: Appl Environ Microbiol doi: 10.1128/aem.63.6.2117-2123.1997 contributor: fullname: L Leloup – volume: 180 start-page: 5421 year: 1998 ident: 2900_CR39 publication-title: Journal of Bacteriology doi: 10.1128/JB.180.20.5421-5425.1998 contributor: fullname: E Zientz – volume: 63 start-page: 133 year: 2009 ident: 2900_CR1 publication-title: Annual review of microbiology doi: 10.1146/annurev.micro.091208.073214 contributor: fullname: R Gao – volume: 10 start-page: e0133389 year: 2015 ident: 2900_CR34 publication-title: PLoS One doi: 10.1371/journal.pone.0133389 contributor: fullname: A Ahmad – volume: 82 start-page: 275 year: 2011 ident: 2900_CR4 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2011.07829.x contributor: fullname: TN Huynh – ident: 2900_CR51 doi: 10.1107/S0907444907037195 – volume: 3 start-page: 1725 year: 1989 ident: 2900_CR3 publication-title: Genes Dev doi: 10.1101/gad.3.11.1725 contributor: fullname: MM Igo – volume: 33 start-page: 1870 year: 2016 ident: 2900_CR64 publication-title: Mol Biol Evol doi: 10.1093/molbev/msw054 contributor: fullname: S Kumar – volume: 297 start-page: 757 year: 2000 ident: 2900_CR45 publication-title: J Mol Biol doi: 10.1006/jmbi.2000.3598 contributor: fullname: RJ Lewis – volume: 79 start-page: 5509 year: 2013 ident: 2900_CR19 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.01177-13 contributor: fullname: JM Landete – volume: 78 start-page: 1936 year: 2012 ident: 2900_CR21 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.07280-11 contributor: fullname: P Mortera – volume: 50 start-page: 1439 year: 2009 ident: 2900_CR15 publication-title: Plant Cell Physiol doi: 10.1093/pcp/pcp089 contributor: fullname: T Sakayori – volume: 139 start-page: 325 year: 2009 ident: 2900_CR37 publication-title: Cell doi: 10.1016/j.cell.2009.08.032 contributor: fullname: P Casino – volume: 52 start-page: 696 year: 2003 ident: 2900_CR61 publication-title: Systematic Biology doi: 10.1080/10635150390235520 contributor: fullname: S Guindon – volume: 426 start-page: 1554 year: 2014 ident: 2900_CR10 publication-title: J Mol Biol doi: 10.1016/j.jmb.2013.12.027 contributor: fullname: J Villali – volume: 21 start-page: 2104 year: 2005 ident: 2900_CR60 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti263 contributor: fullname: F Abascal – volume: 73 start-page: 982 year: 2014 ident: 2900_CR12 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2009.06847.x contributor: fullname: L Tetsch – volume: 192 start-page: 2647 year: 2010 ident: 2900_CR65 publication-title: J Bacteriol doi: 10.1128/JB.00076-10 contributor: fullname: A Maze – ident: 2900_CR47 doi: 10.1128/JB.00190-07 – volume: 5 start-page: e02105 year: 2014 ident: 2900_CR46 publication-title: mBio doi: 10.1128/mBio.02105-14 contributor: fullname: F Trajtenberg – volume: 172 start-page: 3 year: 2010 ident: 2900_CR66 publication-title: Journal of structural biology doi: 10.1016/j.jsb.2010.06.008 contributor: fullname: P Savitsky – volume: 68 start-page: 139 year: 2016 ident: 2900_CR23 publication-title: Adv Microb Physiol doi: 10.1016/bs.ampbs.2016.02.003 contributor: fullname: G Unden – ident: 2900_CR32 doi: 10.1074/jbc.M705081200 – volume: 40 start-page: W573 year: 2012 ident: 2900_CR62 publication-title: Nucleic Acids Research doi: 10.1093/nar/gks485 contributor: fullname: A Boc – volume: 94 start-page: 6815 year: 1997 ident: 2900_CR63 publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.94.13.6815 contributor: fullname: K Strimmer – volume: 20 start-page: 763 year: 2010 ident: 2900_CR5 publication-title: Curr Opin Struct Biol doi: 10.1016/j.sbi.2010.09.010 contributor: fullname: P Casino – volume: 107 start-page: 21140 year: 2010 ident: 2900_CR26 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1013081107 contributor: fullname: TN Huynh – volume: 66 start-page: 486 year: 2010 ident: 2900_CR54 publication-title: Acta Crystallogr D Biol Crystallogr doi: 10.1107/S0907444910007493 contributor: fullname: P Emsley – volume: 13 start-page: 160 year: 2010 ident: 2900_CR29 publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2009.12.009 contributor: fullname: R Gao – volume: 278 start-page: 2140 year: 2011 ident: 2900_CR20 publication-title: FEBS J doi: 10.1111/j.1742-4658.2011.08131.x contributor: fullname: M Espariz – volume: 96 start-page: 329 year: 1974 ident: 2900_CR17 publication-title: Arch Mikrobiol doi: 10.1007/BF00590188 contributor: fullname: M Schutz – volume: 67 start-page: 235 year: 2011 ident: 2900_CR49 publication-title: Acta Crystallogr D Biol Crystallogr doi: 10.1107/S0907444910045749 contributor: fullname: MD Winn – volume: 89 start-page: 718 year: 1992 ident: 2900_CR28 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.89.2.718 contributor: fullname: GS Lukat – volume: 5 start-page: 3258 year: 2014 ident: 2900_CR2 publication-title: Nat Commun doi: 10.1038/ncomms4258 contributor: fullname: P Casino – ident: 2900_CR36 doi: 10.1128/JB.00049-07 – volume: 186 start-page: 5730 year: 2010 ident: 2900_CR14 publication-title: J Bacteriol doi: 10.1128/JB.186.17.5730-5740.2004 contributor: fullname: AA Pioszak – volume: 1553 start-page: 39 year: 2002 ident: 2900_CR42 publication-title: Biochimica et Biophysica Acta (BBA) - Bioenergetics doi: 10.1016/S0005-2728(01)00233-X contributor: fullname: IG Janausch – volume: 78 start-page: 231 year: 2014 ident: 2900_CR48 publication-title: Microbiology and Molecular Biology Reviews doi: 10.1128/MMBR.00001-14 contributor: fullname: J Deutscher – ident: 2900_CR50 doi: 10.1107/S0907444909047337 – volume: 18 start-page: 502 year: 2002 ident: 2900_CR27 publication-title: Bioinformatics doi: 10.1093/bioinformatics/18.3.502 contributor: fullname: HA Schmidt – volume: 67 start-page: 355 year: 2011 ident: 2900_CR53 publication-title: Acta Crystallogr D Biol Crystallogr doi: 10.1107/S0907444911001314 contributor: fullname: GN Murshudov – volume: 198 start-page: 1218 year: 2016 ident: 2900_CR44 publication-title: J Bacteriol doi: 10.1128/JB.00872-15 contributor: fullname: AW Baker – volume: 77 start-page: 771 year: 2009 ident: 2900_CR13 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2010.07247.x contributor: fullname: K Zakikhany – volume: 30 start-page: 3189 year: 2014 ident: 2900_CR33 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu506 contributor: fullname: D Taylor – volume: 13 start-page: 142 year: 2010 ident: 2900_CR8 publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2010.01.015 contributor: fullname: RB Bourret – volume: 297 start-page: 543 year: 2000 ident: 2900_CR9 publication-title: J Mol Biol doi: 10.1006/jmbi.2000.3595 contributor: fullname: HS Cho – volume: 12 start-page: 7 year: 2015 ident: 2900_CR24 publication-title: Nat Methods doi: 10.1038/nmeth.3213 contributor: fullname: J Yang – volume: 149 start-page: 2317 year: 2003 ident: 2900_CR43 publication-title: Microbiology doi: 10.1099/mic.0.26257-0 contributor: fullname: K Tanaka – volume: 18 start-page: 211 year: 2002 ident: 2900_CR55 publication-title: Bioinformatics doi: 10.1093/bioinformatics/18.1.211 contributor: fullname: A Lobley – ident: 2900_CR31 doi: 10.1128/JB.187.24.8229-8230.2005 – volume: 37 start-page: 898 year: 2000 ident: 2900_CR40 publication-title: Molecular Microbiology doi: 10.1046/j.1365-2958.2000.02055.x contributor: fullname: H Yamamoto – volume: 24 start-page: 4247 year: 2005 ident: 2900_CR25 publication-title: The EMBO journal doi: 10.1038/sj.emboj.7600886 contributor: fullname: A Marina – volume: 146 start-page: 263 year: 2000 ident: 2900_CR41 publication-title: Microbiology doi: 10.1099/00221287-146-2-263 contributor: fullname: K Asai – volume: 18 start-page: 533 year: 1995 ident: 2900_CR38 publication-title: Molecular Microbiology doi: 10.1111/j.1365-2958.1995.mmi_18030533.x contributor: fullname: M Bott – volume: 83 start-page: 1162 year: 2015 ident: 2900_CR22 publication-title: Infect Immun doi: 10.1128/IAI.02814-14 contributor: fullname: E Paluscio – volume: 39 start-page: W13 year: 2011 ident: 2900_CR58 publication-title: Nucleic Acids Research doi: 10.1093/nar/gkr245 contributor: fullname: P Di Tommaso – ident: 2900_CR6 doi: 10.1016/j.jmb.2016.08.003 – volume: 17 start-page: 540 year: 2000 ident: 2900_CR59 publication-title: Molecular Biology and Evolution doi: 10.1093/oxfordjournals.molbev.a026334 contributor: fullname: J Castresana – volume: 192 start-page: 3474 year: 2010 ident: 2900_CR16 publication-title: J Bacteriol doi: 10.1128/JB.00082-10 contributor: fullname: PD Scheu – volume: 76 start-page: 84 year: 2010 ident: 2900_CR18 publication-title: Appl Environ Microbiol doi: 10.1128/AEM.02145-09 contributor: fullname: JM Landete – volume: 14 start-page: 3077 year: 2005 ident: 2900_CR35 publication-title: Protein Sci doi: 10.1110/ps.051722805 contributor: fullname: A Toro-Roman – volume: 25 start-page: 24 year: 2000 ident: 2900_CR7 publication-title: Trends Biochem Sci doi: 10.1016/S0968-0004(99)01503-0 contributor: fullname: R Dutta – volume: 40 start-page: 658 year: 2007 ident: 2900_CR52 publication-title: J Appl Crystallogr doi: 10.1107/S0021889807021206 contributor: fullname: AJ McCoy – volume: 289 start-page: 27899 year: 2014 ident: 2900_CR11 publication-title: J Biol Chem doi: 10.1074/jbc.M114.596221 contributor: fullname: S Dintner |
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Snippet | Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the two-component... Abstract Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the... Abstract Microbial colonization of different environments is enabled to a great extent by the plasticity of their sensory mechanisms, among them, the... |
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SubjectTerms | 38 631/326/88 631/535/1266 82 96 Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Citric acid Colonization Conformation Conserved Sequence Dicarboxylic Acids - metabolism Dimerization Genotype & phenotype Histidine Histidine kinase Humanities and Social Sciences Kinases Lactobacillus casei - classification Lactobacillus casei - physiology Malates - metabolism Malic enzyme Models, Biological Models, Molecular Monomers multidisciplinary Phosphorylation Phylogeny Promoter Regions, Genetic Protein Binding Protein Conformation Protein Interaction Domains and Motifs Protein Multimerization Science Science (multidisciplinary) Signal transduction Transduction |
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Title | The malate sensing two-component system MaeKR is a non-canonical class of sensory complex for C4-dicarboxylates |
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