μ-opioid receptor system mediates reward processing in humans

The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) us...

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Published inNature communications Vol. 9; no. 1; pp. 1500 - 7
Main Authors Nummenmaa, Lauri, Saanijoki, Tiina, Tuominen, Lauri, Hirvonen, Jussi, Tuulari, Jetro J., Nuutila, Pirjo, Kalliokoski, Kari
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.04.2018
Nature Publishing Group
Nature Portfolio
Subjects
59/36
59/78
631/378/1488
631/378/1662
631/378/1788
Adult
Amygdala
Amygdala - anatomy & histology
Amygdala - diagnostic imaging
Amygdala - physiology
Analgesics, Opioid - pharmacokinetics
Availability
Body weight gain
Brain Mapping
Fentanyl - analogs & derivatives
Fentanyl - pharmacokinetics
Food
Functional magnetic resonance imaging
Gene Expression
Humanities and Social Sciences
Humans
Hypothalamus
Hypothalamus - anatomy & histology
Hypothalamus - diagnostic imaging
Hypothalamus - physiology
Ligands
Magnetic Resonance Imaging
Male
multidisciplinary
Narcotics
Neostriatum
Obesity
Opioid receptors
Pattern Recognition, Visual - physiology
Photography
Pictures
Positron emission
Positron emission tomography
Receptors, Opioid, mu - genetics
Receptors, Opioid, mu - metabolism
Reinforcement
Science
Science (multidisciplinary)
Tomography
Ventral Striatum - anatomy & histology
Ventral Striatum - diagnostic imaging
Ventral Striatum - physiology
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Abstract The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [ 11 C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity. μ-opioid signalling has a known role in the response to various rewarding stimuli, including pleasant foods. Here, Nummenmaa et al. show using PET and fMRI that individual differences in brain μ-opioid receptor density predict the strength of the neural response to highly palatable foods in humans
AbstractList The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [11C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity.The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [11C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity.
μ-opioid signalling has a known role in the response to various rewarding stimuli, including pleasant foods. Here, Nummenmaa et al. show using PET and fMRI that individual differences in brain μ-opioid receptor density predict the strength of the neural response to highly palatable foods in humans
The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [ C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity.
The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [ 11 C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity.
The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [ 11 C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity. μ-opioid signalling has a known role in the response to various rewarding stimuli, including pleasant foods. Here, Nummenmaa et al. show using PET and fMRI that individual differences in brain μ-opioid receptor density predict the strength of the neural response to highly palatable foods in humans
The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [11C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods. Viewing palatable versus bland foods activates regions involved in homeostatic and reward processing, such as amygdala, ventral striatum, and hypothalamus. MOR availability in the reward and emotion circuit is negatively associated with the fMRI reward responses. Variation in MOR availability may explain why some people feel an urge to eat when encountering food cues, increasing risk for weight gain and obesity.
ArticleNumber 1500
Author Tuominen, Lauri
Tuulari, Jetro J.
Kalliokoski, Kari
Hirvonen, Jussi
Nummenmaa, Lauri
Saanijoki, Tiina
Nuutila, Pirjo
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29662095$$D View this record in MEDLINE/PubMed
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Snippet The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are...
μ-opioid signalling has a known role in the response to various rewarding stimuli, including pleasant foods. Here, Nummenmaa et al. show using PET and fMRI...
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SubjectTerms 59/36
59/78
631/378/1488
631/378/1662
631/378/1788
Adult
Amygdala
Amygdala - anatomy & histology
Amygdala - diagnostic imaging
Amygdala - physiology
Analgesics, Opioid - pharmacokinetics
Availability
Body weight gain
Brain Mapping
Fentanyl - analogs & derivatives
Fentanyl - pharmacokinetics
Food
Functional magnetic resonance imaging
Gene Expression
Humanities and Social Sciences
Humans
Hypothalamus
Hypothalamus - anatomy & histology
Hypothalamus - diagnostic imaging
Hypothalamus - physiology
Ligands
Magnetic Resonance Imaging
Male
multidisciplinary
Narcotics
Neostriatum
Obesity
Opioid receptors
Pattern Recognition, Visual - physiology
Photography
Pictures
Positron emission
Positron emission tomography
Receptors, Opioid, mu - genetics
Receptors, Opioid, mu - metabolism
Reinforcement
Science
Science (multidisciplinary)
Tomography
Ventral Striatum - anatomy & histology
Ventral Striatum - diagnostic imaging
Ventral Striatum - physiology
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Title μ-opioid receptor system mediates reward processing in humans
URI https://link.springer.com/article/10.1038/s41467-018-03848-y
https://www.ncbi.nlm.nih.gov/pubmed/29662095
https://www.proquest.com/docview/2025800611
https://www.proquest.com/docview/2026422185
https://pubmed.ncbi.nlm.nih.gov/PMC5902580
https://doaj.org/article/b7e241c8b67640d69524004501365e8b
Volume 9
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