Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin

• Published in: Nature communications Vol. 14; no. 1; pp. 477 - 13
• Main Authors: Sun, Wen-Long, Hua, Sha, Li, Xin-Yu, Shen, Liang, Wu, Hao, Ji, Hong-Fang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.01.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 38/23; 49/91; 631/154/436; 631/326/2565/2134; 692/4020/4021/1607/2750; Animal models; Animals; Antioxidants - metabolism; Cyanocobalamin; Damage; Disorders; Fatty acids; Fecal microflora; Germfree; Humanities and Social Sciences; Humans; Intestinal microflora; Lipid Metabolism; Lipids; Lipids - pharmacology; Liver; Liver - metabolism; Male; Males; Metabolism; Mice; Microbiota; Microorganisms; multidisciplinary; Rats; Science; Science (multidisciplinary); Silibinin; Silymarin; Silymarin - metabolism; Silymarin - pharmacology; Transcriptomes; Transplantation; Triglycerides; Vitamin B 12 - metabolism; Vitamin B 12 - pharmacology; Vitamin B12

Silymarin has been used for improving hepatic damage and lipid disorders, but its action mechanism remains to be clarified. Here, we investigate the contributions of the gut microbiota to the improvement of liver lipid metabolism by silymarin. We find i) strong and significant microbial shifts upon...