Monocyte-derived and M1 macrophages from ankylosing spondylitis patients released higher TNF-α and expressed more IL1B in response to BzATP than macrophages from healthy subjects

• Published in: Scientific reports Vol. 11; no. 1; pp. 17842 - 10
• Main Authors: Akhtari, Maryam, Zargar, Seyed Jalal, Vojdanian, Mahdi, Jamshidi, Ahmadreza, Mahmoudi, Mahdi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/80; 692/4023/1670/2766/1827; Adenosine triphosphate; Adenosine Triphosphate - analogs & derivatives; Adenosine Triphosphate - metabolism; Adenosine Triphosphate - pharmacology; Adult; Ankylosing spondylitis; Arthritis; ATP; Cellular stress response; Colony-stimulating factor; Cytokines; Female; Gene expression; Humanities and Social Sciences; Humans; IL-1β; Inflammation; Interleukin 1; Interleukin 23; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Lipopolysaccharides; Macrophage colony-stimulating factor; Macrophages - drug effects; Macrophages - metabolism; Male; Monocytes; Monocytes - drug effects; Monocytes - metabolism; multidisciplinary; Patients; Purine receptors; Science; Science (multidisciplinary); Spondylitis, Ankylosing - metabolism; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Up-Regulation - drug effects; Young Adult; γ-Interferon

Macrophages participate in the pathogenesis of ankylosing spondylitis (AS) by producing inflammatory cytokines. Extracellular adenosine triphosphate (eATP), released during cell stress, acts through purinergic receptors (P2XR and P2YR) and induces inflammatory responses. We investigated the effect o...