Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

• Published in: Scientific reports Vol. 8; no. 1; pp. 4159 - 14
• Main Authors: Gherardin, Nicholas A., Loh, Liyen, Admojo, Lorenztino, Davenport, Alexander J., Richardson, Kelden, Rogers, Amy, Darcy, Phillip K., Jenkins, Misty R., Prince, H. Miles, Harrison, Simon J., Quach, Hang, Fairlie, David P., Kedzierska, Katherine, McCluskey, James, Uldrich, Adam P., Neeson, Paul J., Ritchie, David S., Godfrey, Dale I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.03.2018; Nature Publishing Group
• Subjects: 13; 13/31; 14; 14/19; 631/250/1619/554; 631/250/580; 631/67/1990/804; Bone marrow; CD27 antigen; Cell activation; Cytotoxicity; Enumeration; Geriatrics; Humanities and Social Sciences; Immunomodulation; Lymphocytes T; Major histocompatibility complex; Mucosa; multidisciplinary; Multiple myeloma; Natural killer cells; Patients; Phenotypes; Science; Science (multidisciplinary); T cell receptors; Tumors; γ-Interferon

Mucosal-associated invariant T (MAIT) cells are T cells that recognise vitamin-B derivative Ag presented by the MHC-related-protein 1 (MR1) antigen-presenting molecule. While MAIT cells are highly abundant in humans, their role in tumour immunity remains unknown. Here we have analysed the frequency...