Beyond the Debye length in high ionic strength solution: direct protein detection with field-effect transistors (FETs) in human serum
In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high e...
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| Published in | Scientific reports Vol. 7; no. 1; pp. 5256 - 15 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
12.07.2017
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
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| Abstract | In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) are used to directly detect proteins, including HIV-1 RT, CEA, NT-proBNP and CRP, in 1X PBS (with 1%BSA) or human sera. The samples do not need any dilution or washing process to reduce the ionic strength. The sensor shows high sensitivity and the detection takes only 5 minutes. The designs of the sensor, the methodology of the measurement, and the working mechanism of the sensor are discussed and investigated. A theoretical model is proposed based on the finding of the experiments. This sensor is promising for point-of-care, home healthcare, and mobile diagnostic device. |
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| AbstractList | In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) are used to directly detect proteins, including HIV-1 RT, CEA, NT-proBNP and CRP, in 1X PBS (with 1%BSA) or human sera. The samples do not need any dilution or washing process to reduce the ionic strength. The sensor shows high sensitivity and the detection takes only 5 minutes. The designs of the sensor, the methodology of the measurement, and the working mechanism of the sensor are discussed and investigated. A theoretical model is proposed based on the finding of the experiments. This sensor is promising for point-of-care, home healthcare, and mobile diagnostic device. Abstract In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) are used to directly detect proteins, including HIV-1 RT, CEA, NT-proBNP and CRP, in 1X PBS (with 1%BSA) or human sera. The samples do not need any dilution or washing process to reduce the ionic strength. The sensor shows high sensitivity and the detection takes only 5 minutes. The designs of the sensor, the methodology of the measurement, and the working mechanism of the sensor are discussed and investigated. A theoretical model is proposed based on the finding of the experiments. This sensor is promising for point-of-care, home healthcare, and mobile diagnostic device. In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) are used to directly detect proteins, including HIV-1 RT, CEA, NT-proBNP and CRP, in 1X PBS (with 1%BSA) or human sera. The samples do not need any dilution or washing process to reduce the ionic strength. The sensor shows high sensitivity and the detection takes only 5 minutes. The designs of the sensor, the methodology of the measurement, and the working mechanism of the sensor are discussed and investigated. A theoretical model is proposed based on the finding of the experiments. This sensor is promising for point-of-care, home healthcare, and mobile diagnostic device.In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) are used to directly detect proteins, including HIV-1 RT, CEA, NT-proBNP and CRP, in 1X PBS (with 1%BSA) or human sera. The samples do not need any dilution or washing process to reduce the ionic strength. The sensor shows high sensitivity and the detection takes only 5 minutes. The designs of the sensor, the methodology of the measurement, and the working mechanism of the sensor are discussed and investigated. A theoretical model is proposed based on the finding of the experiments. This sensor is promising for point-of-care, home healthcare, and mobile diagnostic device. |
| ArticleNumber | 5256 |
| Author | Chyi, Jen-Inn Shiesh, Shu-Chu Chen, Chih-Chen Chang, Wen-Hsin Wang, Yu-Lin Hsu, Chen-Pin Sarangadharan, Indu Regmi, Abiral Chen, Yen-Wen Chu, Chia-Ho Lee, Geng-Yen Lee, Gwo-Bin |
| Author_xml | – sequence: 1 givenname: Chia-Ho surname: Chu fullname: Chu, Chia-Ho organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University – sequence: 2 givenname: Indu surname: Sarangadharan fullname: Sarangadharan, Indu organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University – sequence: 3 givenname: Abiral surname: Regmi fullname: Regmi, Abiral organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University – sequence: 4 givenname: Yen-Wen surname: Chen fullname: Chen, Yen-Wen organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University – sequence: 5 givenname: Chen-Pin surname: Hsu fullname: Hsu, Chen-Pin organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University – sequence: 6 givenname: Wen-Hsin surname: Chang fullname: Chang, Wen-Hsin organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University – sequence: 7 givenname: Geng-Yen surname: Lee fullname: Lee, Geng-Yen organization: Department of Electrical engineering, National Central University – sequence: 8 givenname: Jen-Inn orcidid: 0000-0001-8149-832X surname: Chyi fullname: Chyi, Jen-Inn organization: Department of Electrical engineering, National Central University – sequence: 9 givenname: Chih-Chen surname: Chen fullname: Chen, Chih-Chen organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University, Department of Power Mechanical Engineering, National Tsing Hua University – sequence: 10 givenname: Shu-Chu surname: Shiesh fullname: Shiesh, Shu-Chu organization: Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University – sequence: 11 givenname: Gwo-Bin surname: Lee fullname: Lee, Gwo-Bin email: gwobin@pme.nthu.edu.tw organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University, Department of Power Mechanical Engineering, National Tsing Hua University, Institute of Biomedical Engineering, National Tsing Hua University – sequence: 12 givenname: Yu-Lin surname: Wang fullname: Wang, Yu-Lin email: ylwang@mx.nthu.edu.tw organization: Institute of Nanoengineering and Microsystems, National Tsing Hua University, Department of Power Mechanical Engineering, National Tsing Hua University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28701708$$D View this record in MEDLINE/PubMed |
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| Snippet | In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect... Abstract In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe... |
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| SubjectTerms | 631/57/2282 639/638/11/511 692/700/139/1449 82/62 9/10 Aptamers Biosensors Humanities and Social Sciences Ionic strength Ions multidisciplinary Science Science (multidisciplinary) Sensors Transistors |
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| Title | Beyond the Debye length in high ionic strength solution: direct protein detection with field-effect transistors (FETs) in human serum |
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