Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 3; p. 437
• Main Authors: Smith, Margaret M, Melrose, James
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: anti-viral; Anticoagulants; Atherosclerosis; Biomimetics; Blood vessels; Bowel disease; Cancer; Cartilage; Cell growth; Chemical properties; cystitis; Diabetes; DMOAD; endothelial cell dysfunction; Growth factors; Heparan sulfate; hyaluronan; Inflammation; Kidneys; Lipids; Pain; Physiological aspects; Physiology; Polysaccharides; Review; Severe acute respiratory syndrome coronavirus 2; Structure; Thrombocytopenia; tissue protection; Trauma; Australia; anti-viral; tissue protection; hyaluronan; anti-inflammatory; DMOAD; cystitis; endothelial cell dysfunction

Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim of this review was to outline the potential of PPS as an interventional therapeutic protective agent in physiological processes affecting pa...