Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues
Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim of this review was to outline the potential of PPS as an interventional therapeutic protective agent in physiological processes affecting pa...
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| Published in | Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 3; p. 437 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
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01.03.2023
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| Abstract | Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim of this review was to outline the potential of PPS as an interventional therapeutic protective agent in physiological processes affecting pathological tissues. PPS is a multifunctional molecule with diverse therapeutic actions against many disease processes. PPS has been used for decades in the treatment of interstitial cystitis and painful bowel disease, it has tissue-protective properties as a protease inhibitor in cartilage, tendon and IVD, and it has been used as a cell-directive component in bioscaffolds in tissue engineering applications. PPS regulates complement activation, coagulation, fibrinolysis and thrombocytopenia, and it promotes the synthesis of hyaluronan. Nerve growth factor production in osteocytes is inhibited by PPS, reducing bone pain in osteoarthritis and rheumatoid arthritis (OA/RA). PPS also removes fatty compounds from lipid-engorged subchondral blood vessels in OA/RA cartilage, reducing joint pain. PPS regulates cytokine and inflammatory mediator production and is also an anti-tumor agent that promotes the proliferation and differentiation of mesenchymal stem cells and the development of progenitor cell lineages that have proven to be useful in strategies designed to effect repair of the degenerate intervertebral disc (IVD) and OA cartilage. PPS stimulates proteoglycan synthesis by chondrocytes in the presence or absence of interleukin (IL)-1, and stimulates hyaluronan production by synoviocytes. PPS is thus a multifunctional tissue-protective molecule of potential therapeutic application for a diverse range of disease processes. |
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| AbstractList | Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim of this review was to outline the potential of PPS as an interventional therapeutic protective agent in physiological processes affecting pathological tissues. PPS is a multifunctional molecule with diverse therapeutic actions against many disease processes. PPS has been used for decades in the treatment of interstitial cystitis and painful bowel disease, it has tissue-protective properties as a protease inhibitor in cartilage, tendon and IVD, and it has been used as a cell-directive component in bioscaffolds in tissue engineering applications. PPS regulates complement activation, coagulation, fibrinolysis and thrombocytopenia, and it promotes the synthesis of hyaluronan. Nerve growth factor production in osteocytes is inhibited by PPS, reducing bone pain in osteoarthritis and rheumatoid arthritis (OA/RA). PPS also removes fatty compounds from lipid-engorged subchondral blood vessels in OA/RA cartilage, reducing joint pain. PPS regulates cytokine and inflammatory mediator production and is also an anti-tumor agent that promotes the proliferation and differentiation of mesenchymal stem cells and the development of progenitor cell lineages that have proven to be useful in strategies designed to effect repair of the degenerate intervertebral disc (IVD) and OA cartilage. PPS stimulates proteoglycan synthesis by chondrocytes in the presence or absence of interleukin (IL)-1, and stimulates hyaluronan production by synoviocytes. PPS is thus a multifunctional tissue-protective molecule of potential therapeutic application for a diverse range of disease processes. |
| Audience | Academic |
| Author | Smith, Margaret M Melrose, James |
| AuthorAffiliation | 3 Sydney Medical School, Northern Campus, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia 2 Graduate Schools of Biomedical Engineering, University of NSW, Sydney, NSW 2052, Australia 1 Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia; mobsmith@sydney.edu.au |
| AuthorAffiliation_xml | – name: 3 Sydney Medical School, Northern Campus, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia – name: 1 Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia; mobsmith@sydney.edu.au – name: 2 Graduate Schools of Biomedical Engineering, University of NSW, Sydney, NSW 2052, Australia |
| Author_xml | – sequence: 1 givenname: Margaret M orcidid: 0000-0002-2020-0056 surname: Smith fullname: Smith, Margaret M organization: Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia – sequence: 2 givenname: James orcidid: 0000-0001-9237-0524 surname: Melrose fullname: Melrose, James organization: Sydney Medical School, Northern Campus, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36986536$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_vetsci11050190 crossref_primary_10_1167_iovs_65_4_27 crossref_primary_10_3390_cells12172161 crossref_primary_10_1016_j_carbpol_2023_121201 crossref_primary_10_1055_a_2126_0346 crossref_primary_10_3390_ijms25021113 |
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| Snippet | Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim... |
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| SubjectTerms | anti-viral Anticoagulants Atherosclerosis Biomimetics Blood vessels Bowel disease Cancer Cartilage Cell growth Chemical properties cystitis Diabetes DMOAD endothelial cell dysfunction Growth factors Heparan sulfate hyaluronan Inflammation Kidneys Lipids Pain Physiological aspects Physiology Polysaccharides Review Severe acute respiratory syndrome coronavirus 2 Structure Thrombocytopenia tissue protection Trauma |
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| Title | Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues |
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