LncRNA TRHDE-AS1 inhibit the scar fibroblasts proliferation via miR-181a-5p/PTEN axis

• Published in: Journal of molecular histology Vol. 52; no. 2; pp. 419 - 426
• Main Authors: Wei, Yanping, Wang, Tingting, Zhang, Ningning, Ma, Yunyun, Shi, Siji, Zhang, Ruxing, Zheng, Xianzhao, Zhao, Lindong
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2021; Springer Nature B.V
• Subjects: Apoptosis; Apoptosis - physiology; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Cell Biology; Cell Proliferation - physiology; Cells, Cultured; Cicatrix, Hypertrophic - metabolism; Developmental Biology; Extracellular matrix; Fibroblasts; Fibroblasts - cytology; Fibroblasts - metabolism; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Humans; Life Sciences; MicroRNAs - genetics; MicroRNAs - metabolism; Non-coding RNA; Original Paper; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; PTEN protein; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Wound healing; Fibroblasts; PTEN; LncRNA TRHDE-AS1; Hypertrophic scar; miR-181-5p

Hypertrophic scar (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Recent studies have shown that some non-coding RNA implicated the formation of HS, but...