Healthy centenarians show high levels of circulating interleukin-22 (IL-22)

• Published in: Archives of gerontology and geriatrics Vol. 54; no. 3; pp. 459 - 461
• Main Authors: Basile, Giorgio, Paffumi, Isidora, D’Angelo, Anna Grazia, Figliomeni, Paolo, Cucinotta, Maria Despina, Pace, Elisabetta, Ferraro, Maria, Saitta, Salvatore, Lasco, Antonino, Gangemi, Sebastiano
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.05.2012
• Subjects: Aged; Aged, 80 and over; Aging - blood; Aging - immunology; Centenarians; Cytokines; Female; First time; Humans; Immune response; Independent living; Inflammaging; Interleukin-22; Interleukin-22 (IL-22); Interleukins - blood; Internal Medicine; Longevity; Longevity - immunology; Male; Middle Aged; Nursing homes; Regulatory T cells; Inflammaging; Centenarians; Cytokines; Regulatory T cells; Interleukin-22 (IL-22)

Aging is characterized by a progressive alteration of homeostatic mechanisms modulated by environmental and genetic factors. It is associated with a pro-inflammatory status. In centenarians, an increase of pro-inflammatory cytokine production balanced by anti-inflammatory immune response that would...