TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways

• Published in: Cell death & disease Vol. 13; no. 5; pp. 472 - 12
• Main Authors: Wang, Li-Na, Zhang, Zi-Teng, Wang, Li, Wei, Hai-Xiang, Zhang, Tao, Zhang, Li-Ming, Lin, Hang, Zhang, Heng, Wang, Shao-Qiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.05.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/31; 631/80/84; 692/699/67/1612; AKT protein; Anoikis; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Line, Tumor; Cell migration; Cell Movement - physiology; Cell proliferation; Epithelial-Mesenchymal Transition - genetics; GRB2 Adaptor Protein - metabolism; Grb2 protein; Humans; Immunology; Janus kinase 2; Janus Kinase 2 - genetics; Janus Kinase 2 - metabolism; Life Sciences; Lung cancer; Lung Neoplasms - pathology; Metastases; Phosphatidylinositol 3-Kinases - metabolism; Prognosis; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1

The pathogenesis of lung cancer, the most common cancer, is complex and unclear, leading to limited treatment options and poor prognosis. To provide molecular insights into lung cancer development, we investigated the function and underlying mechanism of SH2B3 in the regulation of lung cancer. We in...