Meta-analysis of NAD(P)(H) quantification results exhibits variability across mammalian tissues

Nicotinamide Adenine Dinucleotide (NAD + ) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD + metabolism and NAD + -boosting therapies has reinforced the necessity for accurate NAD + quantification. To examine t...

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Published inScientific reports Vol. 13; no. 1; pp. 2464 - 13
Main Authors Azouaoui, Dassine, Choinière, Michael René, Khan, Momtafin, Sayfi, Shahab, Jaffer, Simran, Yousef, Selvia, Patten, David A., Green, Alexander E., Menzies, Keir J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 11.02.2023
Nature Publishing Group
Nature Portfolio
Subjects
631/45/320
692/53/2421
Animal tissues
Animals
Biosynthesis
Dehydrogenases
Energy Metabolism
Enzymes
Health sciences
Homeostasis
Humanities and Social Sciences
Humans
Mammals
Mammals - metabolism
Mass spectrometry
Meta-analysis
Metabolism
Metabolites
Mice
multidisciplinary
NAD
NAD - metabolism
Physiology
Rats
Science
Science (multidisciplinary)
Scientific imaging
Signal transduction
Standardization
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Abstract Nicotinamide Adenine Dinucleotide (NAD + ) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD + metabolism and NAD + -boosting therapies has reinforced the necessity for accurate NAD + quantification. To examine the published NAD(P)(H) measures across mammalian tissues, we performed a meta-analysis of the existing data. An Ovid MEDLINE database search identified articles with NAD(P)(H) quantification results obtained from mammalian tissues published between 1961 and 2021. We screened 4890 records and extracted quantitative data, as well as the quantification methods, pre-analytical conditions, and subject characteristics. The extracted physiological NAD(P)(H) concentrations in various tissues from mice, rats, and humans, revealed an important inter- and intra-method variability that extended to recent publications. This highlights the relatively poor potential for cross-experimental analyses for NAD(P)(H) quantitative data and the importance of standardization for NAD(P)(H) quantification methods and pre-analytical procedures for future preclinical and clinical studies.
AbstractList Nicotinamide Adenine Dinucleotide (NAD + ) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD + metabolism and NAD + -boosting therapies has reinforced the necessity for accurate NAD + quantification. To examine the published NAD(P)(H) measures across mammalian tissues, we performed a meta-analysis of the existing data. An Ovid MEDLINE database search identified articles with NAD(P)(H) quantification results obtained from mammalian tissues published between 1961 and 2021. We screened 4890 records and extracted quantitative data, as well as the quantification methods, pre-analytical conditions, and subject characteristics. The extracted physiological NAD(P)(H) concentrations in various tissues from mice, rats, and humans, revealed an important inter- and intra-method variability that extended to recent publications. This highlights the relatively poor potential for cross-experimental analyses for NAD(P)(H) quantitative data and the importance of standardization for NAD(P)(H) quantification methods and pre-analytical procedures for future preclinical and clinical studies.
Nicotinamide Adenine Dinucleotide (NAD ) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD metabolism and NAD -boosting therapies has reinforced the necessity for accurate NAD quantification. To examine the published NAD(P)(H) measures across mammalian tissues, we performed a meta-analysis of the existing data. An Ovid MEDLINE database search identified articles with NAD(P)(H) quantification results obtained from mammalian tissues published between 1961 and 2021. We screened 4890 records and extracted quantitative data, as well as the quantification methods, pre-analytical conditions, and subject characteristics. The extracted physiological NAD(P)(H) concentrations in various tissues from mice, rats, and humans, revealed an important inter- and intra-method variability that extended to recent publications. This highlights the relatively poor potential for cross-experimental analyses for NAD(P)(H) quantitative data and the importance of standardization for NAD(P)(H) quantification methods and pre-analytical procedures for future preclinical and clinical studies.
Abstract Nicotinamide Adenine Dinucleotide (NAD+) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD+ metabolism and NAD+-boosting therapies has reinforced the necessity for accurate NAD+ quantification. To examine the published NAD(P)(H) measures across mammalian tissues, we performed a meta-analysis of the existing data. An Ovid MEDLINE database search identified articles with NAD(P)(H) quantification results obtained from mammalian tissues published between 1961 and 2021. We screened 4890 records and extracted quantitative data, as well as the quantification methods, pre-analytical conditions, and subject characteristics. The extracted physiological NAD(P)(H) concentrations in various tissues from mice, rats, and humans, revealed an important inter- and intra-method variability that extended to recent publications. This highlights the relatively poor potential for cross-experimental analyses for NAD(P)(H) quantitative data and the importance of standardization for NAD(P)(H) quantification methods and pre-analytical procedures for future preclinical and clinical studies.
Nicotinamide Adenine Dinucleotide (NAD+) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD+ metabolism and NAD+-boosting therapies has reinforced the necessity for accurate NAD+ quantification. To examine the published NAD(P)(H) measures across mammalian tissues, we performed a meta-analysis of the existing data. An Ovid MEDLINE database search identified articles with NAD(P)(H) quantification results obtained from mammalian tissues published between 1961 and 2021. We screened 4890 records and extracted quantitative data, as well as the quantification methods, pre-analytical conditions, and subject characteristics. The extracted physiological NAD(P)(H) concentrations in various tissues from mice, rats, and humans, revealed an important inter- and intra-method variability that extended to recent publications. This highlights the relatively poor potential for cross-experimental analyses for NAD(P)(H) quantitative data and the importance of standardization for NAD(P)(H) quantification methods and pre-analytical procedures for future preclinical and clinical studies.Nicotinamide Adenine Dinucleotide (NAD+) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD+ metabolism and NAD+-boosting therapies has reinforced the necessity for accurate NAD+ quantification. To examine the published NAD(P)(H) measures across mammalian tissues, we performed a meta-analysis of the existing data. An Ovid MEDLINE database search identified articles with NAD(P)(H) quantification results obtained from mammalian tissues published between 1961 and 2021. We screened 4890 records and extracted quantitative data, as well as the quantification methods, pre-analytical conditions, and subject characteristics. The extracted physiological NAD(P)(H) concentrations in various tissues from mice, rats, and humans, revealed an important inter- and intra-method variability that extended to recent publications. This highlights the relatively poor potential for cross-experimental analyses for NAD(P)(H) quantitative data and the importance of standardization for NAD(P)(H) quantification methods and pre-analytical procedures for future preclinical and clinical studies.
Nicotinamide Adenine Dinucleotide (NAD+) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The increased interest in NAD+ metabolism and NAD+-boosting therapies has reinforced the necessity for accurate NAD+ quantification. To examine the published NAD(P)(H) measures across mammalian tissues, we performed a meta-analysis of the existing data. An Ovid MEDLINE database search identified articles with NAD(P)(H) quantification results obtained from mammalian tissues published between 1961 and 2021. We screened 4890 records and extracted quantitative data, as well as the quantification methods, pre-analytical conditions, and subject characteristics. The extracted physiological NAD(P)(H) concentrations in various tissues from mice, rats, and humans, revealed an important inter- and intra-method variability that extended to recent publications. This highlights the relatively poor potential for cross-experimental analyses for NAD(P)(H) quantitative data and the importance of standardization for NAD(P)(H) quantification methods and pre-analytical procedures for future preclinical and clinical studies.
ArticleNumber 2464
Author Green, Alexander E.
Sayfi, Shahab
Khan, Momtafin
Jaffer, Simran
Yousef, Selvia
Azouaoui, Dassine
Patten, David A.
Choinière, Michael René
Menzies, Keir J.
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Snippet Nicotinamide Adenine Dinucleotide (NAD + ) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The...
Nicotinamide Adenine Dinucleotide (NAD ) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The...
Nicotinamide Adenine Dinucleotide (NAD+) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions. The...
Abstract Nicotinamide Adenine Dinucleotide (NAD+) plays an important role in energy metabolism and signaling pathways controlling crucial cellular functions....
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692/53/2421
Animal tissues
Animals
Biosynthesis
Dehydrogenases
Energy Metabolism
Enzymes
Health sciences
Homeostasis
Humanities and Social Sciences
Humans
Mammals
Mammals - metabolism
Mass spectrometry
Meta-analysis
Metabolism
Metabolites
Mice
multidisciplinary
NAD
NAD - metabolism
Physiology
Rats
Science
Science (multidisciplinary)
Scientific imaging
Signal transduction
Standardization
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Title Meta-analysis of NAD(P)(H) quantification results exhibits variability across mammalian tissues
URI https://link.springer.com/article/10.1038/s41598-023-29607-8
https://www.ncbi.nlm.nih.gov/pubmed/36774401
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Volume 13
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