Effect of pulsatile and nonpulsatile flow on cerebral perfusion in patients with left ventricular assist devices

• Published in: The Journal of heart and lung transplantation Vol. 33; no. 12; pp. 1295 - 1303
• Main Authors: Cornwell, William K., Tarumi, Takashi, Aengevaeren, Vincent L., Ayers, Colby, Divanji, Punag, Fu, Qi, Palmer, Dean, Drazner, Mark H., Meyer, Dan M., Bethea, Brian T., Hastings, Jeffrey L., Fujimoto, Naoki, Shibata, Shigeki, Zhang, Rong, Markham, David W., Levine, Benjamin D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2014
• Subjects: Adult; Aged; Blood Pressure - physiology; Cardiac Output - physiology; Case-Control Studies; cerebral autoregulation; cerebral blood flow; Cerebrovascular Circulation - physiology; Female; Heart Failure - physiopathology; Heart Failure - therapy; Heart-Assist Devices; Hemodynamics - physiology; Homeostasis - physiology; Humans; LVAD; Male; Middle Aged; nonpulsatile flow; Pulsatile Flow - physiology; Regional Blood Flow - physiology; Surgery; sympathetic activity; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - therapy; cerebral blood flow; sympathetic activity; nonpulsatile flow; LVAD; cerebral autoregulation

Insertion of a left ventricular assist device (LVAD) is an accepted therapy for advanced heart failure patients. However, the effects on end-organ perfusion, including cerebral autoregulation, are unclear in the presence of reduced pulsatility. Therefore, the objective of this study was to determine...