ROS networks: designs, aging, Parkinson’s disease and precision therapies

• Published in: NPJ systems biology and applications Vol. 6; no. 1; p. 34
• Main Authors: N. Kolodkin, Alexey, Sharma, Raju Prasad, Colangelo, Anna Maria, Ignatenko, Andrew, Martorana, Francesca, Jennen, Danyel, Briedé, Jacco J., Brady, Nathan, Barberis, Matteo, Mondeel, Thierry D. G. A., Papa, Michele, Kumar, Vikas, Peters, Bernhard, Skupin, Alexander, Alberghina, Lilia, Balling, Rudi, Westerhoff, Hans V.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.10.2020; Nature Publishing Group
• Subjects: 631/553/2695; 631/553/2700; 631/553/2703; 631/553/2710; 631/553/2717; Aging; Antioxidants; Bioinformatics; Biomedical and Life Sciences; Caffeine; Computational Biology; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Humans; Life Sciences; Mitochondria; Models, Biological; Molecular Targeted Therapy; Movement disorders; Neurodegenerative diseases; Oxidative Stress; PARK7 protein; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Precision Medicine; Reactive Oxygen Species - metabolism; Synuclein; Systems Biology

How the network around ROS protects against oxidative stress and Parkinson’s disease (PD), and how processes at the minutes timescale cause disease and aging after decades, remains enigmatic. Challenging whether the ROS network is as complex as it seems, we built a fairly comprehensive version there...