Differences in the bacteriome of swab, saliva, and tissue biopsies in oral cancer

• Published in: Scientific reports Vol. 11; no. 1; pp. 1181 - 13
• Main Authors: Gopinath, Divya, Menon, Rohit Kunnath, Wie, Chong Chun, Banerjee, Moinak, Panda, Swagatika, Mandal, Deviprasad, Behera, Paresh Kumar, Roychoudhury, Susanta, Kheur, Supriya, Botelho, Michael George, Johnson, Newell W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/2565; 631/326/2565/2134; 631/326/2565/2142; 631/326/2565/855; 631/67; 631/67/1536; 631/67/1665; Acetoin; Biodegradation; Biosynthesis; Carbohydrate metabolism; Community structure; Dysbacteriosis; Genera; Humanities and Social Sciences; Inflammation; Metabolic pathways; Metabolism; Microbiomes; multidisciplinary; Oral cancer; Polymers; Saliva; Science; Science (multidisciplinary); Streptococcus; Tissues; Tumors

Microbial dysbiosis has been implicated in the pathogenesis of oral cancer. We analyzed the compositional and metabolic profile of the bacteriome in three specific niches in oral cancer patients along with controls using 16SrRNA sequencing (Illumina Miseq) and DADA2 software. We found major differen...