Reconstituting the complete biosynthesis of D-lysergic acid in yeast

• Published in: Nature communications Vol. 13; no. 1; p. 712
• Main Authors: Wong, Garrett, Lim, Li Rong, Tan, Yong Quan, Go, Maybelle Kho, Bell, David J., Freemont, Paul S., Yew, Wen Shan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.02.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 101/47; 101/58; 101/6; 42/44; 631/45/607; 631/92/349/977; 631/92/552; 631/92/60; 9/10; Alkaloids; Basal ganglia; Biodegradation; Bioreactors; Biosynthesis; Biosynthetic Pathways; Central nervous system diseases; Chemical reactions; Chemical synthesis; Dementia disorders; Enantiomers; Ergot; Ergot Alkaloids - chemistry; Ergot Alkaloids - metabolism; Fermentation; Fungi; Humanities and Social Sciences; Lysergic Acid - chemistry; Lysergic Acid - metabolism; Molecular Structure; Movement disorders; multidisciplinary; Natural products; Pharmacology; Precursors; Production methods; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Science; Science (multidisciplinary); Yeast; Yeasts

The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments, such as Parkinsonism and dementia. Their synthesis via chemical and biological routes are therefore of industrial relevance, b...