Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

• Published in: Nature communications Vol. 12; no. 1; pp. 174 - 17
• Main Authors: Wang, Xu, Hu, Li-Peng, Qin, Wei-Ting, Yang, Qin, Chen, De-Yu, Li, Qing, Zhou, Kai-Xia, Huang, Pei-Qi, Xu, Chun-Jie, Li, Jun, Yao, Lin-Li, Wang, Ya-Hui, Tian, Guang-Ang, Yang, Jian-Yu, Yang, Min-Wei, Liu, De-Jun, Sun, Yong-Wei, Jiang, Shu-Heng, Zhang, Xue-Li, Zhang, Zhi-Gang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 14; 14/1; 14/19; 14/34; 38; 38/91; 42; 631/67/327; 96/31; Adenocarcinoma; Animals; Antibodies; B7-H1 Antigen - metabolism; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - pathology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Disease Models, Animal; Gene sequencing; Heterogeneity; Humanities and Social Sciences; Immunosuppressive Agents - pharmacology; Leukocytes (neutrophilic); Liver; Liver cancer; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Lymphocytes; Lymphocytes T; Male; Metastases; Metastasis; Mice; Mice, Knockout; Mitochondria; Mitochondria - metabolism; multidisciplinary; Neutrophils; Neutrophils - metabolism; NF-E2-Related Factor 2 - metabolism; Pancreas - immunology; Pancreas - pathology; Pancreatic cancer; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - pathology; PD-1 protein; PD-L1 protein; Phenotypes; Receptors, Purinergic P2X - genetics; Receptors, Purinergic P2X - immunology; Receptors, Purinergic P2X - metabolism; Regulatory mechanisms (biology); Ribonucleic acid; RNA; Science; Science (multidisciplinary); Tumor microenvironment; Tumor Microenvironment - immunology; Tumors
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-020-20447-y

The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important components of the metastatic tumor microenvironment and exhibit heterogeneity. However, the specifi...