A cross-sectional study of ocular surface discomfort and corneal nerve dysfunction after paclitaxel treatment for cancer

• Published in: Scientific reports Vol. 11; no. 1; pp. 1786 - 10
• Main Authors: Chiang, Jeremy Chung Bo, Goldstein, David, Trinh, Terry, Au, Kimberley, Park, Susanna B., Krishnan, Arun V., Markoulli, Maria
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/1807; 692/1807/1482; 692/617/375/430; 692/699/67/1059/99; 692/700/784; Cancer; Chemotherapy; Confocal microscopy; Cornea; Cross-sectional studies; Eye; Eye diseases; Humanities and Social Sciences; Longitudinal studies; multidisciplinary; Neurotoxicity; Paclitaxel; Patients; Peripheral neuropathy; Science; Science (multidisciplinary); Visual perception
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-81398-y

Ocular surface dysfunction is common in patients receiving anti-cancer drug treatment. The effects of paclitaxel, a neurotoxic chemotherapeutic drug, on ocular surface discomfort associated with dry eye disease was investigated. Patients with cancer who had completed paclitaxel treatment between 3 a...