Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders

• Published in: Translational psychiatry Vol. 10; no. 1; p. 373
• Main Authors: Greene, Chris, Hanley, Nicole, Campbell, Matthew
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.11.2020; Nature Publishing Group
• Subjects: 13; 14; 14/19; 631/378/340; 692/699/476; 82; 82/51; Behavioral Sciences; Biological Psychology; Blood-brain barrier; Blood-Brain Barrier - metabolism; Claudin-5 - metabolism; Female; Humans; Male; Medicine; Medicine & Public Health; Mental disorders; Mental Disorders - metabolism; Neurosciences; Pharmacotherapy; Psychiatry; Schizophrenia; Tight Junctions - metabolism

Major psychiatric disorders affect 25% of the population. While genetic and environmental risk factors have been identified, the underlying pathophysiology of conditions, such as schizophrenia, bipolar disorder and major depression remains largely unknown. Here, we show that endothelial associated t...