HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells

• Published in: Cell reports (Cambridge) Vol. 36; no. 13; p. 109757
• Main Authors: Lu, Haiquan, Lyu, Yajing, Tran, Linh, Lan, Jie, Xie, Yangyiran, Yang, Yongkang, Murugan, Naveena L., Wang, Yueyang J., Semenza, Gregg L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.09.2021; Elsevier
• Subjects: aldehyde dehydrogenase; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Hypoxia - physiology; Gene Expression Regulation, Neoplastic - genetics; Humans; hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; mammosphere; Nanog Homeobox Protein - metabolism; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Neoplastic Stem Cells - metabolism; pluripotency factor; proteasome; Telomerase - metabolism; telomere; tumor-initiating cells; ubiquitination; hypoxia; proteasome; aldehyde dehydrogenase; ubiquitination; pluripotency factor; telomere; tumor-initiating cells; mammosphere

Breast cancer stem cells (BCSCs) play essential roles in tumor formation, drug resistance, relapse, and metastasis. NANOG is a protein required for stem cell self-renewal, but the mechanisms by which it performs this function are poorly understood. Here, we show that hypoxia-inducible factor 1α (HIF...