Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewe...

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Published in	Signal transduction and targeted therapy Vol. 7; no. 1; pp. 3 - 23
Main Authors	Liu, Jiaqi, Xiao, Qing, Xiao, Jiani, Niu, Chenxi, Li, Yuanyuan, Zhang, Xiaojun, Zhou, Zhengwei, Shu, Guang, Yin, Gang
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 03.01.2022 Nature Publishing Group
Subjects	631/136/2441 631/337/384 631/67/395 631/67/68 692/700/155 Animals beta Catenin - genetics beta Catenin - metabolism Cancer Cancer Research Cell Biology Cell growth Clinical trials Embryogenesis Endoplasmic reticulum Genes Homeostasis Humans Internal Medicine Kinases Ligands Lipids Medicine Medicine & Public Health Metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - metabolism Oncology Pathology Phosphorylation Plasma Proteins Regulation Review Review Article Signal transduction Tumors Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism Wnt Signaling Pathway β-Catenin
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Abstract	The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
AbstractList	The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment. Abstract The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment. The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
ArticleNumber	3
Author	Xiao, Qing Niu, Chenxi Xiao, Jiani Zhou, Zhengwei Li, Yuanyuan Liu, Jiaqi Yin, Gang Shu, Guang Zhang, Xiaojun
Author_xml	– sequence: 1 givenname: Jiaqi surname: Liu fullname: Liu, Jiaqi organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University – sequence: 2 givenname: Qing surname: Xiao fullname: Xiao, Qing organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University – sequence: 3 givenname: Jiani surname: Xiao fullname: Xiao, Jiani organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University – sequence: 4 givenname: Chenxi surname: Niu fullname: Niu, Chenxi organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University – sequence: 5 givenname: Yuanyuan surname: Li fullname: Li, Yuanyuan organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University – sequence: 6 givenname: Xiaojun surname: Zhang fullname: Zhang, Xiaojun organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University – sequence: 7 givenname: Zhengwei surname: Zhou fullname: Zhou, Zhengwei organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University – sequence: 8 givenname: Guang surname: Shu fullname: Shu, Guang organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Department of Histology and Embryology, School of Basic Medical Sciences, Central South University – sequence: 9 givenname: Gang orcidid: 0000-0003-3753-0753 surname: Yin fullname: Yin, Gang email: gangyin@csu.edu.cn organization: Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, China-Africa Research Center of Infectious Diseases, School of Basic Medical sciences, Central South University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34980884$$D View this record in MEDLINE/PubMed
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Snippet	The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of... Abstract The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The...
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SubjectTerms	631/136/2441 631/337/384 631/67/395 631/67/68 692/700/155 Animals beta Catenin - genetics beta Catenin - metabolism Cancer Cancer Research Cell Biology Cell growth Clinical trials Embryogenesis Endoplasmic reticulum Genes Homeostasis Humans Internal Medicine Kinases Ligands Lipids Medicine Medicine & Public Health Metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - metabolism Oncology Pathology Phosphorylation Plasma Proteins Regulation Review Review Article Signal transduction Tumors Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism Wnt Signaling Pathway β-Catenin
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Title	Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
URI	https://link.springer.com/article/10.1038/s41392-021-00762-6 https://www.ncbi.nlm.nih.gov/pubmed/34980884 https://www.proquest.com/docview/2615909533 https://www.proquest.com/docview/2616610676 https://pubmed.ncbi.nlm.nih.gov/PMC8724284 https://doaj.org/article/910400280fd140a69090e0dab18737eb
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