Monocytic myeloid-derived suppressive cells mitigate over-adipogenesis of bone marrow microenvironment in aplastic anemia by inhibiting CD8+ T cells

• Published in: Cell death & disease Vol. 13; no. 7; pp. 620 - 14
• Main Authors: Qu, Ying, Sun, Zhengxu, Yuan, Yan, Li, Zifeng, Wang, Fen, Wu, Kunpeng, Yu, Huihui, Lin, Qiwang, Fei, He, Chen, Jian, Qian, Maoxiang, Cheng, Yunfeng, Jiang, Hua, Chen, Tong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.07.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/100; 13/21; 14/19; 14/35; 38/39; 38/90; 38/91; 45/77; 631/250/251; 692/420/2780; Adipogenesis; Anemia; Anemia, Aplastic; Animals; Antibodies; Aplastic anemia; Biochemistry; Biomedical and Life Sciences; Bone marrow; Bone Marrow - metabolism; Bone Marrow Cells - metabolism; CD11b antigen; CD8 antigen; CD8-Positive T-Lymphocytes; Cell Biology; Cell Culture; Cell differentiation; Cell proliferation; CXCL12 protein; Hemopoiesis; Immunology; Life Sciences; Lymphocytes; Lymphocytes T; Mesenchyme; Mice; Microenvironments; Monocytes; Nitric oxide; Nitric-oxide synthase; Osteoblastogenesis; Pancytopenia; Progenitor cells; Stroma; γ-Interferon

Aplastic anemia (AA) is a blood disorder resulted from over-activated T-cell related hematopoietic failure, with the characterization of hypocellularity and enhanced adipogenic differentiation of mesenchymal stroma cells (MSCs) in bone marrow (BM). However, little is known about the relationship bet...