Designing siRNA/chitosan-methacrylate complex nanolipogel for prolonged gene silencing effects

• Published in: Scientific reports Vol. 12; no. 1; pp. 3527 - 13
• Main Authors: Cao, Ye, Tan, Yang Fei, Wong, Yee Shan, Aminuddin, Muhammad, Ramya, Bhuthalingam, Liew, Melvin Wen Jie, Liu, Jiaxin, Venkatraman, Subbu S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 639/925; Chitosan; Chitosan - metabolism; Clinical trials; Controlled release; Cytoplasm; Delayed-Action Preparations; Encapsulation; Endocytosis; Gene Silencing; Gene therapy; Humanities and Social Sciences; Lipids; Materials science; Methacrylates; multidisciplinary; Nanoparticles; Polymers; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; siRNA; Transfection

Despite immense revolutionary therapeutics potential, sustaining release of active small interfering RNA (siRNA) remains an arduous challenge. The development of nanoparticles with siRNA sustained release capabilities provides an avenue to enhance the therapeutic efficacy of gene-based therapy. Here...