Analysis of the twenty-six largest outbreaks of tuberculosis in Aragon using whole-genome sequencing for surveillance purposes

• Published in: Scientific reports Vol. 12; no. 1; p. 18766
• Main Authors: Comín, Jessica, Cebollada, Alberto, Ibarz, Daniel, Viñuelas, Jesús, Sahagún, Juan, Torres, Luis, Iglesias, María-José, Samper, Sofía
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/41/1470; 631/326/41/2530; 631/326/421; Disease Outbreaks; Epidemiology; Genomes; Genotype; Humanities and Social Sciences; Humans; multidisciplinary; Mycobacterium tuberculosis - genetics; Outbreaks; Polymorphism, Restriction Fragment Length; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Strains (organisms); Surveillance; Tuberculosis; Tuberculosis - epidemiology; Virulence factors; Whole genome sequencing

The incidence of tuberculosis in Aragon, Spain, is around ten cases per 100,000 inhabitants. Since 2004, a molecular surveillance protocol has been carried out; therefore, all M. tuberculosis strains are genotyped. Recently, whole-genome sequencing has been implemented for relevant isolates. The aim...