IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

• Published in: Nature communications Vol. 12; no. 1; pp. 2133 - 9
• Main Authors: Stanczak, Michal A., Sanin, David E., Apostolova, Petya, Nerz, Gabriele, Lampaki, Dimitrios, Hofmann, Maike, Steinmann, Daniel, Krohn-Grimberghe, Marvin, Thimme, Robert, Mittler, Gerhard, Waller, Cornelius F., Pearce, Edward J., Pearce, Erika L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/31; 38; 45; 631/250/127/1213; 631/326/596/4130; 692/308/174; 82/80; Adolescent; Adult; Aged; Alveoli; Antibodies; Antibodies, Viral - immunology; Asthma; Bronchus; CD14 antigen; CD4 antigen; Cell activation; Child; Child, Preschool; Chronic infection; Chronic obstructive pulmonary disease; Coronaviruses; Correlation; COVID-19; COVID-19 - immunology; COVID-19 - virology; Female; Fever; Glycoproteins; Humanities and Social Sciences; Humans; IL-1β; Immune response; Immune system; Immunoglobulin G; Immunoglobulin G - immunology; Immunoglobulin M; Infections; Interleukin 23; Interleukin 6; Interleukin-33 - immunology; Interleukin-33 - metabolism; Lung diseases; Lymphocytes; Lymphocytes T; Male; Middle Aged; Monocytes; multidisciplinary; Observational studies; Pathogenesis; Respiratory diseases; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - physiology; Science; Science (multidisciplinary); Seroepidemiologic Studies; Serology; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Spike glycoprotein; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; TLR7 protein; Toll-like receptors; Tumor necrosis factor; Viral diseases; Young Adult

Our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still developing. We perform an observational study to investigate seroprevalence and immune responses in subjects professionally exposed to SARS-CoV-2 and their family members (155 individuals; ages 5–79 years). Se...