Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility

• Published in: Scientific reports Vol. 7; no. 1; pp. 10011 - 16
• Main Authors: Wang, Ning, Satirapod, Chonthicha, Ohguchi, Yasuyo, Park, Eun-Sil, Woods, Dori C., Tilly, Jonathan L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.08.2017; Nature Publishing Group
• Subjects: 14; 14/34; 38; 38/77; 631/136; 631/80; Animals; Cell Differentiation; Cre recombinase; Female; Fertility; Ganciclovir; Germ cells; Herpes simplex; Humanities and Social Sciences; Kinases; Mammals; Meiosis; Mice, Transgenic; multidisciplinary; Offspring; Oocytes; Oocytes - physiology; Oogonial Stem Cells - physiology; Ovaries; Ovary - physiology; Reporter gene; Reproductive status; Retinoic acid; Rodents; Science; Science (multidisciplinary); Stem cell transplantation; Stem cells; Suicide; Suicide genes; Thymidine; Thymidine kinase; Transgenic mice

Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible...