Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility

Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 7; no. 1; pp. 10011 - 16
Main Authors Wang, Ning, Satirapod, Chonthicha, Ohguchi, Yasuyo, Park, Eun-Sil, Woods, Dori C., Tilly, Jonathan L.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 30.08.2017
Nature Publishing Group
Subjects
14
14/34
38
38/77
631/136
631/80
Animals
Cell Differentiation
Cre recombinase
Female
Fertility
Ganciclovir
Germ cells
Herpes simplex
Humanities and Social Sciences
Kinases
Mammals
Meiosis
Mice, Transgenic
multidisciplinary
Offspring
Oocytes
Oocytes - physiology
Oogonial Stem Cells - physiology
Ovaries
Ovary - physiology
Reporter gene
Reproductive status
Retinoic acid
Rodents
Science
Science (multidisciplinary)
Stem cell transplantation
Stem cells
Suicide
Suicide genes
Thymidine
Thymidine kinase
Transgenic mice
Online AccessGet full text

Cover

Abstract Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in transgenic mice expressing the suicide gene, herpes simplex virus thymidine kinase ( HSVtk ), driven by the promoter of stimulated by retinoic acid gene 8 ( Stra8 ), a germ cell-specific gene activated during meiotic commitment. Over a 21-day ablation phase induced by the HSVtk pro-drug, ganciclovir (GCV), oocyte numbers declined due to a disruption of new oocyte input. However, germ cell differentiation resumed after ceasing the ablation protocol, enabling complete regeneration of the oocyte pool. We next employed inducible lineage tracing to fate map, through Cre recombinase-mediated fluorescent reporter gene activation only in Stra8 -expressing cells, newly-formed oocytes. Induction of the system during adulthood yielded a mosaic pool of unmarked (pre-existing) and marked (newly-formed) oocytes. Marked oocytes matured and fertilized to produce offspring, which grew normally to adulthood and transmitted the reporter to second-generation offspring. These findings establish that oocytes generated during adulthood contribute directly to ovarian function and natural fertility in mammals.
AbstractList Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in transgenic mice expressing the suicide gene, herpes simplex virus thymidine kinase ( HSVtk ), driven by the promoter of stimulated by retinoic acid gene 8 ( Stra8 ), a germ cell-specific gene activated during meiotic commitment. Over a 21-day ablation phase induced by the HSVtk pro-drug, ganciclovir (GCV), oocyte numbers declined due to a disruption of new oocyte input. However, germ cell differentiation resumed after ceasing the ablation protocol, enabling complete regeneration of the oocyte pool. We next employed inducible lineage tracing to fate map, through Cre recombinase-mediated fluorescent reporter gene activation only in Stra8 -expressing cells, newly-formed oocytes. Induction of the system during adulthood yielded a mosaic pool of unmarked (pre-existing) and marked (newly-formed) oocytes. Marked oocytes matured and fertilized to produce offspring, which grew normally to adulthood and transmitted the reporter to second-generation offspring. These findings establish that oocytes generated during adulthood contribute directly to ovarian function and natural fertility in mammals.
Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in transgenic mice expressing the suicide gene, herpes simplex virus thymidine kinase (HSVtk), driven by the promoter of stimulated by retinoic acid gene 8 (Stra8), a germ cell-specific gene activated during meiotic commitment. Over a 21-day ablation phase induced by the HSVtk pro-drug, ganciclovir (GCV), oocyte numbers declined due to a disruption of new oocyte input. However, germ cell differentiation resumed after ceasing the ablation protocol, enabling complete regeneration of the oocyte pool. We next employed inducible lineage tracing to fate map, through Cre recombinase-mediated fluorescent reporter gene activation only in Stra8-expressing cells, newly-formed oocytes. Induction of the system during adulthood yielded a mosaic pool of unmarked (pre-existing) and marked (newly-formed) oocytes. Marked oocytes matured and fertilized to produce offspring, which grew normally to adulthood and transmitted the reporter to second-generation offspring. These findings establish that oocytes generated during adulthood contribute directly to ovarian function and natural fertility in mammals.
Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in transgenic mice expressing the suicide gene, herpes simplex virus thymidine kinase (HSVtk), driven by the promoter of stimulated by retinoic acid gene 8 (Stra8), a germ cell-specific gene activated during meiotic commitment. Over a 21-day ablation phase induced by the HSVtk pro-drug, ganciclovir (GCV), oocyte numbers declined due to a disruption of new oocyte input. However, germ cell differentiation resumed after ceasing the ablation protocol, enabling complete regeneration of the oocyte pool. We next employed inducible lineage tracing to fate map, through Cre recombinase-mediated fluorescent reporter gene activation only in Stra8-expressing cells, newly-formed oocytes. Induction of the system during adulthood yielded a mosaic pool of unmarked (pre-existing) and marked (newly-formed) oocytes. Marked oocytes matured and fertilized to produce offspring, which grew normally to adulthood and transmitted the reporter to second-generation offspring. These findings establish that oocytes generated during adulthood contribute directly to ovarian function and natural fertility in mammals.Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce offspring. However, the physiological relevance of these observations to adult ovarian function is unknown. Here we performed targeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in transgenic mice expressing the suicide gene, herpes simplex virus thymidine kinase (HSVtk), driven by the promoter of stimulated by retinoic acid gene 8 (Stra8), a germ cell-specific gene activated during meiotic commitment. Over a 21-day ablation phase induced by the HSVtk pro-drug, ganciclovir (GCV), oocyte numbers declined due to a disruption of new oocyte input. However, germ cell differentiation resumed after ceasing the ablation protocol, enabling complete regeneration of the oocyte pool. We next employed inducible lineage tracing to fate map, through Cre recombinase-mediated fluorescent reporter gene activation only in Stra8-expressing cells, newly-formed oocytes. Induction of the system during adulthood yielded a mosaic pool of unmarked (pre-existing) and marked (newly-formed) oocytes. Marked oocytes matured and fertilized to produce offspring, which grew normally to adulthood and transmitted the reporter to second-generation offspring. These findings establish that oocytes generated during adulthood contribute directly to ovarian function and natural fertility in mammals.
ArticleNumber 10011
Author Wang, Ning
Satirapod, Chonthicha
Park, Eun-Sil
Woods, Dori C.
Tilly, Jonathan L.
Ohguchi, Yasuyo
Author_xml – sequence: 1
  givenname: Ning
  surname: Wang
  fullname: Wang, Ning
  organization: Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston
– sequence: 2
  givenname: Chonthicha
  surname: Satirapod
  fullname: Satirapod, Chonthicha
  organization: Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston
– sequence: 3
  givenname: Yasuyo
  surname: Ohguchi
  fullname: Ohguchi, Yasuyo
  organization: Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston
– sequence: 4
  givenname: Eun-Sil
  surname: Park
  fullname: Park, Eun-Sil
  organization: Department of Biology, Laboratory of Aging and Infertility Research, Northeastern University, Boston, Genetics Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston
– sequence: 5
  givenname: Dori C.
  surname: Woods
  fullname: Woods, Dori C.
  organization: Department of Biology, Laboratory of Aging and Infertility Research, Northeastern University, Boston
– sequence: 6
  givenname: Jonathan L.
  surname: Tilly
  fullname: Tilly, Jonathan L.
  email: j.tilly@northeastern.edu
  organization: Department of Biology, Laboratory of Aging and Infertility Research, Northeastern University, Boston
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28855574$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1rFTEYhYO02Fr7B1xIwI2b0XzOZDaCFK1CwU27DpnknTZ1bnKbj8L99831tuVa0GwSeM85PG_OG3QQYgCE3lHyiRKuPmdB5ag6QoeOEsJ5179Cx4wI2THO2MHe-wid5nxL2pFsFHR8jY6YUlLKQRyju3MIULzFuVTnIWMf8MpbwM4nsGXZ4MWH3zhGuyltuk7RVQsOu5p8uMbG1aXcxOhwiTjem-RNwHMNtvgYsAkOB1NqMgueIRW_-LJ5iw5ns2Q4fbxP0NX3b5dnP7qLX-c_z75edFYKUjqlht5RKXsx9QCTacjTpCj0ktgZRjWBHVhbTzDgAuQ4kn6W0o6DZbQ3QvET9GWXu67TCpyFUBqHXie_Mmmjo_H670nwN_o63uv2MS15bAEfHwNSvKuQi175bGFZTIBYs6YjF42Kk630wwvpbawptPWaqsVJToloqvf7RM8oT200gdoJbIo5J5i19cVsv7IB-kVTorfd6133unWv_3Sv-2ZlL6xP6f818Z0pr7dtQtrD_rfrASR0wqM
CitedBy_id crossref_primary_10_23902_trkjnat_483495
crossref_primary_10_1177_1179558119848007
crossref_primary_10_1093_stmcls_sxac015
crossref_primary_10_1016_j_fertnstert_2018_12_015
crossref_primary_10_3390_cells11071135
crossref_primary_10_3389_fendo_2019_00772
crossref_primary_10_3390_brainsci9030052
crossref_primary_10_3389_fmed_2022_837022
crossref_primary_10_1007_s43032_020_00411_3
crossref_primary_10_2478_acb_2019_0018
crossref_primary_10_1016_j_gofs_2019_02_011
crossref_primary_10_3390_cimb44050157
crossref_primary_10_1177_2633494120917350
crossref_primary_10_3389_fcell_2022_942652
crossref_primary_10_18632_aging_101808
crossref_primary_10_3390_life13051195
crossref_primary_10_1089_scd_2022_0284
crossref_primary_10_3390_cells8020093
crossref_primary_10_1080_13697137_2020_1804547
crossref_primary_10_3390_ani13152520
crossref_primary_10_1093_biolre_ioab115
crossref_primary_10_1186_s13048_020_00647_2
crossref_primary_10_1093_stmcls_sxac083
crossref_primary_10_1007_s12015_021_10237_4
crossref_primary_10_1159_000519087
crossref_primary_10_1530_REP_18_0061
crossref_primary_10_1093_pq_pqae071
crossref_primary_10_1089_scd_2021_0086
crossref_primary_10_3390_ijms222212482
crossref_primary_10_18632_aging_103080
crossref_primary_10_1093_humupd_dmy031
Cites_doi 10.1016/j.diff.2010.01.001
10.1177/1933719115612137
10.1038/ng1919
10.1073/pnas.0601083103
10.1016/j.fertnstert.2013.07.1978
10.1073/pnas.1306189110
10.1038/nbt950
10.1016/S0925-4773(01)00620-7
10.1038/339538a0
10.1016/j.fertnstert.2012.05.005
10.1038/nature00927
10.1093/jmcb/mjq043
10.1038/srep28218
10.1038/nm.3966
10.1210/jcem-65-6-1231
10.1055/s-2007-980218
10.1083/jcb.135.2.469
10.1038/ncb1869
10.1007/978-1-4939-3795-0_19
10.1677/joe.0.0210469
10.1177/1933719112462632
10.1038/sj.cr.7310123
10.1016/S0012-1606(03)00391-9
10.1016/S0092-8674(00)81571-8
10.1073/pnas.1206600109
10.1007/s10517-016-3345-y
10.1186/1471-213X-3-1
10.1038/nrg952
10.1095/biolreprod28.2.255
10.1016/S0140-6736(14)60308-1
10.1038/srep05580
10.1046/j.1440-169x.1999.00474.x
10.4161/cc.9.2.10447
10.1038/nature11287
10.1073/pnas.91.25.12258
10.1038/nn1340
10.1073/pnas.91.24.11298
10.1242/dev.001107
10.1186/s13048-015-0184-9
10.1038/nature03994
10.1126/science.1185473
10.1038/sj.gt.3300379
10.1016/j.fertnstert.2008.10.030
10.1095/biolreprod.105.045591
10.1530/rep.1.01128
10.18632/aging.100105
10.1038/nm.3964
10.1093/molehr/gau071
10.1371/journal.pgen.1002575
10.1016/j.ymthe.2017.04.019
10.1186/s13059-016-1023-z
10.1016/S0925-4773(00)00283-5
10.1182/blood-2003-11-4011
10.1038/nature06196
10.1055/s-0035-1567826
10.1016/j.fertnstert.2009.12.053
10.1093/molehr/gaw015
10.1126/science.1137741
10.1177/096032719701600905
10.1146/annurev.cellbio.19.111301.155141
10.1093/molehr/gat081
10.1634/stemcells.2005-0580
10.1016/j.fertnstert.2013.06.036
10.1038/nm.2669
10.1038/sj.gt.3300784
10.1089/scd.2011.0091
10.4172/2375-4508.1000154
10.1038/nature02316
10.1038/nature08209
10.1074/jbc.273.10.5858
10.1038/nprot.2013.047
10.1016/0012-1606(84)90035-6
10.1371/journal.pone.0139824
10.1038/nature04697
10.1093/molehr/gaw030
10.1038/nm.3775
10.1126/science.1191996
10.1371/journal.pone.0103985
10.1073/pnas.0807297105
10.1073/pnas.91.24.11303
10.1016/j.maturitas.2015.07.017
10.1016/S0925-4773(02)00087-4
ContentType Journal Article
Copyright The Author(s) 2017
2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2017
– notice: 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/s41598-017-10033-6
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni)
Medical Database
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef
Publicly Available Content Database
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen Free (Free internet resource, activated by CARLI)
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 16
ExternalDocumentID PMC5577229
28855574
10_1038_s41598_017_10033_6
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NICHD NIH HHS
  grantid: R21 HD072280
– fundername: NIA NIH HHS
  grantid: R01 AG012279
– fundername: NIA NIH HHS
  grantid: R00 AG039512
– fundername: NIA NIH HHS
  grantid: K99 AG039512
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AARCD
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c540t-8876d15564b6eeba288bb81e650cfe98bec7223242e34e59906f55c97c216a483
IEDL.DBID M48
ISSN 2045-2322
IngestDate Thu Aug 21 13:46:58 EDT 2025
Tue Aug 05 09:50:42 EDT 2025
Wed Aug 13 04:49:45 EDT 2025
Thu Apr 03 06:57:44 EDT 2025
Thu Apr 24 22:50:44 EDT 2025
Tue Jul 01 02:40:55 EDT 2025
Fri Feb 21 02:40:29 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-8876d15564b6eeba288bb81e650cfe98bec7223242e34e59906f55c97c216a483
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41598-017-10033-6
PMID 28855574
PQID 1957753104
PQPubID 2041939
PageCount 16
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5577229
proquest_miscellaneous_1934288309
proquest_journals_1957753104
pubmed_primary_28855574
crossref_citationtrail_10_1038_s41598_017_10033_6
crossref_primary_10_1038_s41598_017_10033_6
springer_journals_10_1038_s41598_017_10033_6
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-08-30
PublicationDateYYYYMMDD 2017-08-30
PublicationDate_xml – month: 08
  year: 2017
  text: 2017-08-30
  day: 30
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2017
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Richardson, Senikas, Nelson (CR8) 1987; 65
Zou (CR12) 2009; 11
Woods, Tilly (CR17) 2013; 8
Fakih (CR29) 2015; 3
Jameson (CR60) 2012; 8
Anderson (CR67) 2008; 105
Sabour (CR61) 2014; 9
Woods, Tilly (CR92) 2012; 98
Zheng, Dean (CR69) 2007; 25
Park, Tilly (CR26) 2015; 21
Gong (CR79) 2010; 93
Saitou, Barton, Surani (CR42) 2002; 418
Faqi, Klug, Merker, Chahoud (CR74) 1997; 16
Imudia (CR18) 2013; 100
Woods, White, Tilly (CR62) 2013; 20
Touraine, Ishii-Morita, Ramsey, Blaese (CR86) 1998; 5
Woods, Tilly (CR78) 2015; 33
Yoshimizu (CR58) 1999; 41
Zhang (CR83) 2016; 17
Morris (CR54) 2004; 22
Chen (CR88) 2012; 488
Page, Hawley (CR75) 2004; 20
Zhang (CR37) 2015; 21
Brinster (CR2) 2007; 316
Richards, Fong, Bongso (CR41) 2008; 93
Zhang (CR15) 2011; 3
Borrelli, Heyman, Arias, Sawchenko, Evans (CR47) 1989; 339
Wu (CR35) 2017; 25
Kerr (CR11) 2006; 132
Pacchiarotti (CR13) 2010; 79
Oktay (CR31) 2015; 22
Brinster, Avarbock (CR56) 1994; 91
Toyooka (CR39) 2000; 93
Johnson, Canning, Kaneko, Pru, Tilly (CR10) 2004; 428
Park, Yu, Marquis, DeCherney, Wolff (CR32) 2016; 23
CR45
Grieve, McLaughlin, Dunlop, Telfer, Anderson (CR27) 2015; 83
Zhang (CR36) 2012; 109
CR44
Oulad-Abdelghani (CR63) 1996; 135
Silvestris, D’Oronzo, Cafforio, D’Amato, Loverno (CR28) 2015; 8
Rogakou, Pilch, Orr, Ivanova, Bonner (CR76) 1998; 273
Niikura, Niikura, Tilly (CR77) 2009; 1
Khosravi-Farsani, Amidi, Roudkenar, Sobhani (CR24) 2015; 16
Guo, Li, Wang, He, Zheng (CR89) 2016; 22
Fujiwara (CR9) 1994; 91
CR81
Kirilly, Xie (CR3) 2007; 17
Visnjic (CR49) 2004; 103
Carter, Smith, Ryan (CR40) 2004; 11
Shen (CR82) 2016; 36
Ishii-Morita (CR85) 1997; 4
Gosden, Laing, Felicio, Nelson, Finch (CR7) 1983; 28
Xiong (CR25) 2015; 10
Zhang, Ebata, Robaire, Nagano (CR91) 2006; 74
Ding (CR33) 2016; 6
Lei, Spradling (CR80) 2013; 110
Ryu, Orwig, Oatley, Avarbock, Brinster (CR90) 2006; 24
CR59
Lange, Saitou, Western, Barton, Surani (CR43) 2003; 3
Barker (CR52) 2007; 449
Dunlop, Bayne, McLaughlin, Telfer, Anderson (CR22) 2014; 383
Zhang, Wu (CR34) 2016; 22
Park, Woods, Tilly (CR19) 2013; 100
Jones, Krohn (CR94) 1961; 21
Wolff (CR20) 2014; 21
Wang, Tilly (CR70) 2010; 9
Bowles, Koopman (CR66) 2007; 134
Brinster, Zimmermann (CR55) 1994; 91
Menke, Koubova, Page (CR64) 2003; 262
Borovskaya, Dygai, Fomina, Vychuzhanina (CR84) 2016; 161
Zuckerman (CR5) 1951; 6
Nakamura, Kobayashi, Nishimura, Higashijima, Tanaka (CR4) 2010; 328
Faddy, Telfer, Gosden (CR6) 1987; 20
Zhou (CR21) 2014; 20
East, Mattison, Dean (CR73) 1984; 104
Navaroli, Tilly, Woods (CR93) 2016; 1457
Ahn, Joyner (CR51) 2005; 437
Suzumori, Yan, Matzuk, Rajkovic (CR71) 2002; 111
Garcia, Doan, Imura, Bush, Sofroniew (CR48) 2004; 7
Lin (CR1) 2002; 3
Navaroli, Tilly, Woods (CR46) 2016; 1457
Hernandez (CR38) 2015; 21
Bush (CR87) 1998; 93
Woods, Tilly (CR30) 2015; 21
Rubtsov (CR50) 2010; 329
Baltus (CR65) 2006; 38
Pangas (CR72) 2006; 103
White (CR16) 2012; 18
Xie, Wang, Wu (CR23) 2014; 4
Lepper, Conway, Fan (CR53) 2009; 460
Zou, Hou, Sun, Xie, Wu (CR14) 2011; 20
Kanatsu-Shinohara, Morimoto, Shinohara (CR57) 2016; 94
Guan (CR68) 2006; 440
DC Woods (10033_CR78) 2015; 33
K Guo (10033_CR89) 2016; 22
N Suzumori (10033_CR71) 2002; 111
RJ Morris (10033_CR54) 2004; 22
J Xiong (10033_CR25) 2015; 10
M Saitou (10033_CR42) 2002; 418
MJ Faddy (10033_CR6) 1987; 20
YAR White (10033_CR16) 2012; 18
C Wu (10033_CR35) 2017; 25
AD Garcia (10033_CR48) 2004; 7
EC Jones (10033_CR94) 1961; 21
K Oktay (10033_CR31) 2015; 22
M Richards (10033_CR41) 2008; 93
E Borrelli (10033_CR47) 1989; 339
T Yoshimizu (10033_CR58) 1999; 41
DC Woods (10033_CR92) 2012; 98
RL Brinster (10033_CR56) 1994; 91
P Carter (10033_CR40) 2004; 11
10033_CR59
H Lin (10033_CR1) 2002; 3
RL Brinster (10033_CR2) 2007; 316
AN Imudia (10033_CR18) 2013; 100
TG Borovskaya (10033_CR84) 2016; 161
D Sabour (10033_CR61) 2014; 9
SP Gong (10033_CR79) 2010; 93
AE Baltus (10033_CR65) 2006; 38
S Khosravi-Farsani (10033_CR24) 2015; 16
EP Rogakou (10033_CR76) 1998; 273
Y Niikura (10033_CR77) 2009; 1
JB Kerr (10033_CR11) 2006; 132
CE Dunlop (10033_CR22) 2014; 383
MH Fakih (10033_CR29) 2015; 3
SA Jameson (10033_CR60) 2012; 8
K Zou (10033_CR12) 2009; 11
SJ Richardson (10033_CR8) 1987; 65
M Oulad-Abdelghani (10033_CR63) 1996; 135
P Zheng (10033_CR69) 2007; 25
W Xie (10033_CR23) 2014; 4
J Bowles (10033_CR66) 2007; 134
DC Woods (10033_CR17) 2013; 8
S Ahn (10033_CR51) 2005; 437
10033_CR45
S Zuckerman (10033_CR5) 1951; 6
S Park (10033_CR32) 2016; 23
10033_CR44
C Zhang (10033_CR34) 2016; 22
SF Hernandez (10033_CR38) 2015; 21
AS Faqi (10033_CR74) 1997; 16
N Barker (10033_CR52) 2007; 449
SA Pangas (10033_CR72) 2006; 103
J Pacchiarotti (10033_CR13) 2010; 79
ES Park (10033_CR19) 2013; 100
D Navaroli (10033_CR93) 2016; 1457
10033_CR81
RL Touraine (10033_CR86) 1998; 5
TG Bush (10033_CR87) 1998; 93
M Kanatsu-Shinohara (10033_CR57) 2016; 94
H Zhang (10033_CR37) 2015; 21
X Ding (10033_CR33) 2016; 6
Y Toyooka (10033_CR39) 2000; 93
E Silvestris (10033_CR28) 2015; 8
EL Anderson (10033_CR67) 2008; 105
XL Zhang (10033_CR83) 2016; 17
KM Grieve (10033_CR27) 2015; 83
DC Woods (10033_CR62) 2013; 20
SL Page (10033_CR75) 2004; 20
TT Shen (10033_CR82) 2016; 36
K Zou (10033_CR14) 2011; 20
K Guan (10033_CR68) 2006; 440
Y Fujiwara (10033_CR9) 1994; 91
H Zhang (10033_CR36) 2012; 109
RG Gosden (10033_CR7) 1983; 28
DB Menke (10033_CR64) 2003; 262
L Zhou (10033_CR21) 2014; 20
D Kirilly (10033_CR3) 2007; 17
J Chen (10033_CR88) 2012; 488
C Lepper (10033_CR53) 2009; 460
N Wang (10033_CR70) 2010; 9
Y Zhang (10033_CR15) 2011; 3
RL Brinster (10033_CR55) 1994; 91
IJ East (10033_CR73) 1984; 104
L Lei (10033_CR80) 2013; 110
X Zhang (10033_CR91) 2006; 74
D Navaroli (10033_CR46) 2016; 1457
UC Lange (10033_CR43) 2003; 3
D Visnjic (10033_CR49) 2004; 103
S Nakamura (10033_CR4) 2010; 328
YP Rubtsov (10033_CR50) 2010; 329
H Ishii-Morita (10033_CR85) 1997; 4
BY Ryu (10033_CR90) 2006; 24
J Johnson (10033_CR10) 2004; 428
ES Park (10033_CR26) 2015; 21
DC Woods (10033_CR30) 2015; 21
EF Wolff (10033_CR20) 2014; 21
References_xml – volume: 79
  start-page: 159
  year: 2010
  end-page: 170
  ident: CR13
  article-title: Differentiation potential of germ line stem cells derived from the postnatal mouse ovary
  publication-title: Differentiation
  doi: 10.1016/j.diff.2010.01.001
– volume: 22
  start-page: 1612
  year: 2015
  end-page: 1617
  ident: CR31
  article-title: Oogonial precursor cell derived autologous mitochondria injection (AMI) to improve outcomes in women with multiple IVF failures due to low oocyte quality: a clinical translation
  publication-title: Reprod. Sci.
  doi: 10.1177/1933719115612137
– ident: CR45
– volume: 38
  start-page: 1430
  year: 2006
  end-page: 1434
  ident: CR65
  article-title: In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication
  publication-title: Nat. Genet.
  doi: 10.1038/ng1919
– volume: 103
  start-page: 8090
  year: 2006
  end-page: 8095
  ident: CR72
  article-title: Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0601083103
– volume: 100
  start-page: 1468
  year: 2013
  end-page: 1475
  ident: CR19
  article-title: Bone morphogenetic protein 4 (BMP4) promotes mammalian oogonial stem cell differentiation via SMAD1/5/8 signaling
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2013.07.1978
– volume: 110
  start-page: 8585
  year: 2013
  end-page: 8590
  ident: CR80
  article-title: Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1306189110
– volume: 22
  start-page: 411
  year: 2004
  end-page: 417
  ident: CR54
  article-title: Capturing and profiling adult hair follicle stem cells
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt950
– volume: 111
  start-page: 137
  year: 2002
  end-page: 141
  ident: CR71
  article-title: Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes
  publication-title: Mech Dev
  doi: 10.1016/S0925-4773(01)00620-7
– volume: 23
  issue: Supplement
  year: 2016
  ident: CR32
  article-title: Egg from ovarian-derived stem cells develops into embryo after intracytoplasmic sperm injection
  publication-title: Reprod. Sci.
– volume: 11
  start-page: 659
  year: 2004
  end-page: 687
  ident: CR40
  article-title: Identification and validation of cell surface antigens for antibody targeting in oncology
  publication-title: Fertil. Steril.
– volume: 339
  start-page: 538
  year: 1989
  end-page: 541
  ident: CR47
  article-title: Transgenic mice with inducible dwarfism
  publication-title: Nature
  doi: 10.1038/339538a0
– volume: 98
  start-page: 3
  year: 2012
  end-page: 10
  ident: CR92
  article-title: The next (re)generation of human ovarian biology and female fertility: is current science tomorrow’s practice?
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2012.05.005
– volume: 418
  start-page: 293
  year: 2002
  end-page: 300
  ident: CR42
  article-title: A molecular programme for the specification of germ cell fate in mice
  publication-title: Nature
  doi: 10.1038/nature00927
– volume: 3
  start-page: 132
  year: 2011
  end-page: 141
  ident: CR15
  article-title: Production of transgenic mice by random recombination of targeted genes in female germline stem cells
  publication-title: J. Mol. Cell Biol.
  doi: 10.1093/jmcb/mjq043
– volume: 6
  year: 2016
  ident: CR33
  article-title: Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates
  publication-title: Sci. Rep.
  doi: 10.1038/srep28218
– volume: 21
  start-page: 1114
  year: 2015
  end-page: 1116
  ident: CR38
  article-title: Characterization of extracellular DDX4- or Ddx4-positive ovarian cells
  publication-title: Nat. Med.
  doi: 10.1038/nm.3966
– volume: 65
  start-page: 1231
  year: 1987
  end-page: 1237
  ident: CR8
  article-title: Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jcem-65-6-1231
– volume: 21
  issue: Supplement
  year: 2014
  ident: CR20
  article-title: Oogonial stem cells generate mature oocytes in an autologous Rhesus macaque transplantation model
  publication-title: Reprod. Sci.
– volume: 25
  start-page: 243
  year: 2007
  end-page: 251
  ident: CR69
  article-title: Oocyte-specific genes affect folliculogenesis, fertilization, and early development
  publication-title: Semin. Reprod. Med.
  doi: 10.1055/s-2007-980218
– volume: 20
  start-page: 551
  year: 1987
  end-page: 560
  ident: CR6
  article-title: The kinetics of pre-antral follicle development in ovaries of CBA/Ca mice during the first 14 weeks of life
  publication-title: Cell Tiss. Kinet.
– volume: 135
  start-page: 469
  year: 1996
  end-page: 477
  ident: CR63
  article-title: Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by , a novel retinoic acid-responsive gene
  publication-title: J. Cell. Biol.
  doi: 10.1083/jcb.135.2.469
– volume: 11
  start-page: 631
  year: 2009
  end-page: 636
  ident: CR12
  article-title: Production of offspring from a germline stem cell line derived from neonatal ovaries
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1869
– volume: 1457
  start-page: 253
  year: 2016
  end-page: 268
  ident: CR46
  article-title: Isolation of mammalian oogonial stem cells by antibody-based fluorescence-activated cell sorting
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-3795-0_19
– volume: 21
  start-page: 469
  year: 1961
  end-page: 495
  ident: CR94
  article-title: The relationships between age, numbers of oocytes and fertility in virgin and multiparous mice
  publication-title: J. Endocrinol.
  doi: 10.1677/joe.0.0210469
– volume: 20
  start-page: 7
  year: 2013
  end-page: 15
  ident: CR62
  article-title: Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view towards the future
  publication-title: Reprod. Sci.
  doi: 10.1177/1933719112462632
– volume: 17
  start-page: 15
  year: 2007
  end-page: 25
  ident: CR3
  article-title: The ovary: an active stem cell community
  publication-title: Cell Res.
  doi: 10.1038/sj.cr.7310123
– volume: 262
  start-page: 303
  year: 2003
  end-page: 312
  ident: CR64
  article-title: Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave
  publication-title: Dev. Biol.
  doi: 10.1016/S0012-1606(03)00391-9
– volume: 93
  start-page: 189
  year: 1998
  end-page: 201
  ident: CR87
  article-title: Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81571-8
– volume: 109
  start-page: 12580
  year: 2012
  end-page: 12585
  ident: CR36
  article-title: Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1206600109
– volume: 161
  start-page: 61
  year: 2016
  end-page: 63
  ident: CR84
  article-title: Quantitative evaluation of primordial follicles in rat ovaries during early and delayed terms after different cytostatic exposures
  publication-title: Bull. Exp. Biol. Med.
  doi: 10.1007/s10517-016-3345-y
– volume: 3
  year: 2003
  ident: CR43
  article-title: The interferon-inducible gene family of transmembrane proteins is associated with germ cell fate specification in mice
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-3-1
– volume: 3
  start-page: 931
  year: 2002
  end-page: 940
  ident: CR1
  article-title: The stem-cell niche theory: lessons from flies
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg952
– volume: 28
  start-page: 255
  year: 1983
  end-page: 260
  ident: CR7
  article-title: Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J mice
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod28.2.255
– volume: 383
  year: 2014
  ident: CR22
  article-title: Isolation, purification, and culture of oogonial stem cells from adult human and bovine ovarian cortex
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)60308-1
– volume: 4
  year: 2014
  ident: CR23
  article-title: Similar morphological and molecular signatures shared by female and male germline stem cells
  publication-title: Sci. Reports
  doi: 10.1038/srep05580
– volume: 41
  start-page: 675
  year: 1999
  end-page: 684
  ident: CR58
  article-title: Germline-specific expression of the OCT-4/green fluorescent protein (GFP) transgene in mice
  publication-title: Dev. Growth Differ.
  doi: 10.1046/j.1440-169x.1999.00474.x
– volume: 9
  start-page: 339
  year: 2010
  end-page: 349
  ident: CR70
  article-title: Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.2.10447
– volume: 488
  start-page: 522
  year: 2012
  end-page: 526
  ident: CR88
  article-title: A restricted cell population propagates glioblastoma growth after chemotherapy
  publication-title: Nature
  doi: 10.1038/nature11287
– ident: CR81
– volume: 91
  start-page: 12258
  year: 1994
  end-page: 12262
  ident: CR9
  article-title: Isolation of a DEAD-family protein gene that encodes a murine homolog of vasa and its specific expression in germ cell lineage
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.25.12258
– volume: 7
  start-page: 1233
  year: 2004
  end-page: 1241
  ident: CR48
  article-title: GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1340
– volume: 91
  start-page: 11298
  year: 1994
  end-page: 11302
  ident: CR55
  article-title: Spermatogenesis following male germ-cell transplantation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.24.11298
– volume: 134
  start-page: 3401
  year: 2007
  end-page: 3411
  ident: CR66
  article-title: Retinoic acid, meiosis and germ cell fate in mammals
  publication-title: Development
  doi: 10.1242/dev.001107
– volume: 8
  year: 2015
  ident: CR28
  article-title: Perspective in infertility: the ovarian stem cells
  publication-title: J. Ovarian Res.
  doi: 10.1186/s13048-015-0184-9
– volume: 437
  start-page: 894
  year: 2005
  end-page: 897
  ident: CR51
  article-title: analysis of quiescent adult neural stem cells responding to Sonic hedgehog
  publication-title: Nature
  doi: 10.1038/nature03994
– volume: 328
  start-page: 1561
  year: 2010
  end-page: 1563
  ident: CR4
  article-title: Identification of germline stem cells in the ovary of the teleost medaka
  publication-title: Science
  doi: 10.1126/science.1185473
– volume: 6
  start-page: 63
  year: 1951
  end-page: 108
  ident: CR5
  article-title: The number of oocytes in the mature ovary
  publication-title: Rec. Prog. Horm. Res.
– volume: 16
  start-page: 406
  year: 2015
  end-page: 415
  ident: CR24
  article-title: Isolation and enrichment of mouse female germline stem cells
  publication-title: Cell J.
– volume: 4
  start-page: 244
  year: 1997
  end-page: 251
  ident: CR85
  article-title: Mechanism of ‘bystander effect’ killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3300379
– volume: 93
  start-page: 986
  year: 2008
  end-page: 994
  ident: CR41
  article-title: Comparative evaluation of different in vitro systems that stimulate germ cell differentiation in human embryonic stem cells
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2008.10.030
– volume: 74
  start-page: 119
  year: 2006
  end-page: 124
  ident: CR91
  article-title: Aging of male germ line stem cells in mice
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod.105.045591
– volume: 132
  start-page: 95
  year: 2006
  end-page: 109
  ident: CR11
  article-title: Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply
  publication-title: Reproduction
  doi: 10.1530/rep.1.01128
– volume: 1
  start-page: 971
  year: 2009
  end-page: 978
  ident: CR77
  article-title: Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment
  publication-title: Aging
  doi: 10.18632/aging.100105
– volume: 21
  start-page: 1118
  year: 2015
  end-page: 1121
  ident: CR30
  article-title: Reply to adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
  publication-title: Nat. Med.
  doi: 10.1038/nm.3964
– volume: 21
  start-page: 58
  year: 2015
  end-page: 65
  ident: CR26
  article-title: Use of ( ) gene promoter-driven fluorescent reporter mice to identify mitotically active germ cells in postnatal mouse ovaries
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gau071
– volume: 8
  year: 2012
  ident: CR60
  article-title: Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002575
– volume: 25
  start-page: 1408
  year: 2017
  end-page: 1419
  ident: CR35
  article-title: Tracing and characterizing the development of transplanted female germline stem cells
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2017.04.019
– volume: 17
  year: 2016
  ident: CR83
  article-title: Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1023-z
– volume: 94
  year: 2016
  ident: CR57
  article-title: Fertility of male germline stem cells following spermatogonial transplantation in infertile mouse models
  publication-title: Biol. Reprod.
– volume: 93
  start-page: 139
  year: 2000
  end-page: 149
  ident: CR39
  article-title: Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development
  publication-title: Mech. Dev.
  doi: 10.1016/S0925-4773(00)00283-5
– volume: 103
  start-page: 3258
  year: 2004
  end-page: 3264
  ident: CR49
  article-title: Hematopoiesis is severely altered in mice with an induced osteoblast deficiency
  publication-title: Blood
  doi: 10.1182/blood-2003-11-4011
– volume: 36
  start-page: 157
  year: 2016
  end-page: 162
  ident: CR82
  article-title: Genome wide profiling of alternative polyadenylation in mouse female germline stem cells
  publication-title: Nan Fang Yi Da Xue Xue Bao
– volume: 449
  start-page: 1003
  year: 2007
  end-page: 1007
  ident: CR52
  article-title: Identification of stem cells in small intestine and colon by marker gene
  publication-title: Nature
  doi: 10.1038/nature06196
– volume: 33
  start-page: 410
  year: 2015
  end-page: 421
  ident: CR78
  article-title: Autologous germline mitochondrial energy transfer (AUGMENT) in assisted human reproduction
  publication-title: Semin. Reprod. Med.
  doi: 10.1055/s-0035-1567826
– volume: 93
  start-page: 2594
  year: 2010
  end-page: 2601
  ident: CR79
  article-title: Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2009.12.053
– volume: 22
  start-page: 316
  year: 2016
  end-page: 328
  ident: CR89
  article-title: Germ stem cells are active in postnatal mouse ovary under physiological conditions
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gaw015
– volume: 316
  start-page: 404
  year: 2007
  end-page: 405
  ident: CR2
  article-title: Male germline stem cells: from mice to men
  publication-title: Science
  doi: 10.1126/science.1137741
– volume: 16
  start-page: 505
  year: 1997
  end-page: 511
  ident: CR74
  article-title: Ganciclovir induces reproductive hazards in male rats after short-term exposure
  publication-title: Hum. Exp. Toxicol.
  doi: 10.1177/096032719701600905
– volume: 20
  start-page: 525
  year: 2004
  end-page: 558
  ident: CR75
  article-title: The genetics and molecular biology of the synaptonemal complex
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev.cellbio.19.111301.155141
– volume: 20
  start-page: 271
  year: 2014
  end-page: 281
  ident: CR21
  article-title: Production of transgenic rats using a post-natal female germline stem cell line
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gat081
– volume: 24
  start-page: 1505
  year: 2006
  end-page: 1511
  ident: CR90
  article-title: Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2005-0580
– ident: CR44
– volume: 100
  start-page: 1451
  year: 2013
  end-page: 1458
  ident: CR18
  article-title: Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2013.06.036
– volume: 18
  start-page: 413
  year: 2012
  end-page: 421
  ident: CR16
  article-title: Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
  publication-title: Nat. Med.
  doi: 10.1038/nm.2669
– volume: 5
  start-page: 1705
  year: 1998
  end-page: 1711
  ident: CR86
  article-title: The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3300784
– volume: 1457
  start-page: 253
  year: 2016
  end-page: 268
  ident: CR93
  article-title: Isolation of oogonial stem cells by antibody-based fluorescence-activated sorting
  publication-title: Meth. Mol. Biol.
  doi: 10.1007/978-1-4939-3795-0_19
– volume: 20
  start-page: 2197
  year: 2011
  end-page: 2204
  ident: CR14
  article-title: Improved efficiency of female germline stem cell purification using Fragilis-based magnetic bead sorting
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2011.0091
– volume: 3
  year: 2015
  ident: CR29
  article-title: The AUGMENT treatment: physician reported outcomes of the initial global patient experience
  publication-title: JFIV Reprod. Med. Genet.
  doi: 10.4172/2375-4508.1000154
– volume: 428
  start-page: 145
  year: 2004
  end-page: 150
  ident: CR10
  article-title: Germline stem cells and follicular renewal in the postnatal mammalian ovary
  publication-title: Nature
  doi: 10.1038/nature02316
– volume: 460
  start-page: 627
  year: 2009
  end-page: 631
  ident: CR53
  article-title: Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements
  publication-title: Nature
  doi: 10.1038/nature08209
– volume: 273
  start-page: 5858
  year: 1998
  end-page: 5868
  ident: CR76
  article-title: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.10.5858
– volume: 8
  start-page: 966
  year: 2013
  end-page: 988
  ident: CR17
  article-title: Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.047
– volume: 104
  start-page: 49
  year: 1984
  end-page: 56
  ident: CR73
  article-title: Monoclonal antibodies to the major protein of the murine zona pellucida: effects on fertilization and early development
  publication-title: Dev. Biol.
  doi: 10.1016/0012-1606(84)90035-6
– volume: 10
  year: 2015
  ident: CR25
  article-title: Intraovarian transplantation of female germline stem cells rescues ovarian function in chemotherapy injured ovaries
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0139824
– volume: 440
  start-page: 1199
  year: 2006
  end-page: 1203
  ident: CR68
  article-title: Pluripotency of spermatogonial stem cells from adult mouse testis
  publication-title: Nature
  doi: 10.1038/nature04697
– volume: 22
  start-page: 457
  year: 2016
  end-page: 464
  ident: CR34
  article-title: Production of offspring from a germline stem cell line derived from prepubertal ovaries of germline reporter mice
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gaw030
– volume: 21
  start-page: 1116
  year: 2015
  end-page: 1118
  ident: CR37
  article-title: Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
  publication-title: Nat. Med.
  doi: 10.1038/nm.3775
– ident: CR59
– volume: 329
  start-page: 1667
  year: 2010
  end-page: 1671
  ident: CR50
  article-title: Stability of the regulatory T cell lineage
  publication-title: Science
  doi: 10.1126/science.1191996
– volume: 9
  year: 2014
  ident: CR61
  article-title: Germ cell nuclear factor regulates gametogenesis in developing gonads
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0103985
– volume: 105
  start-page: 14976
  year: 2008
  end-page: 14980
  ident: CR67
  article-title: Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0807297105
– volume: 91
  start-page: 11303
  year: 1994
  end-page: 11307
  ident: CR56
  article-title: Germline transmission of donor haplotype following spermatogonial transplantation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.24.11303
– volume: 83
  start-page: 278
  year: 2015
  end-page: 281
  ident: CR27
  article-title: The controversial existence and functional potential of oogonial stem cells
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2015.07.017
– volume: 16
  start-page: 505
  year: 1997
  ident: 10033_CR74
  publication-title: Hum. Exp. Toxicol.
  doi: 10.1177/096032719701600905
– volume: 21
  start-page: 58
  year: 2015
  ident: 10033_CR26
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gau071
– volume: 111
  start-page: 137
  year: 2002
  ident: 10033_CR71
  publication-title: Mech Dev
  doi: 10.1016/S0925-4773(01)00620-7
– volume: 20
  start-page: 271
  year: 2014
  ident: 10033_CR21
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gat081
– volume: 1457
  start-page: 253
  year: 2016
  ident: 10033_CR46
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-3795-0_19
– volume: 3
  start-page: 132
  year: 2011
  ident: 10033_CR15
  publication-title: J. Mol. Cell Biol.
  doi: 10.1093/jmcb/mjq043
– volume: 1457
  start-page: 253
  year: 2016
  ident: 10033_CR93
  publication-title: Meth. Mol. Biol.
  doi: 10.1007/978-1-4939-3795-0_19
– volume: 93
  start-page: 986
  year: 2008
  ident: 10033_CR41
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2008.10.030
– volume: 110
  start-page: 8585
  year: 2013
  ident: 10033_CR80
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1306189110
– volume: 83
  start-page: 278
  year: 2015
  ident: 10033_CR27
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2015.07.017
– volume: 28
  start-page: 255
  year: 1983
  ident: 10033_CR7
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod28.2.255
– volume: 1
  start-page: 971
  year: 2009
  ident: 10033_CR77
  publication-title: Aging
  doi: 10.18632/aging.100105
– ident: 10033_CR45
– volume: 94
  year: 2016
  ident: 10033_CR57
  publication-title: Biol. Reprod.
– volume: 16
  start-page: 406
  year: 2015
  ident: 10033_CR24
  publication-title: Cell J.
– volume: 17
  start-page: 15
  year: 2007
  ident: 10033_CR3
  publication-title: Cell Res.
  doi: 10.1038/sj.cr.7310123
– volume: 132
  start-page: 95
  year: 2006
  ident: 10033_CR11
  publication-title: Reproduction
  doi: 10.1530/rep.1.01128
– volume: 20
  start-page: 2197
  year: 2011
  ident: 10033_CR14
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2011.0091
– volume: 3
  year: 2015
  ident: 10033_CR29
  publication-title: JFIV Reprod. Med. Genet.
  doi: 10.4172/2375-4508.1000154
– volume: 23
  issue: Supplement
  year: 2016
  ident: 10033_CR32
  publication-title: Reprod. Sci.
– volume: 428
  start-page: 145
  year: 2004
  ident: 10033_CR10
  publication-title: Nature
  doi: 10.1038/nature02316
– volume: 91
  start-page: 11303
  year: 1994
  ident: 10033_CR56
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.24.11303
– volume: 460
  start-page: 627
  year: 2009
  ident: 10033_CR53
  publication-title: Nature
  doi: 10.1038/nature08209
– volume: 135
  start-page: 469
  year: 1996
  ident: 10033_CR63
  publication-title: J. Cell. Biol.
  doi: 10.1083/jcb.135.2.469
– volume: 21
  start-page: 1118
  year: 2015
  ident: 10033_CR30
  publication-title: Nat. Med.
  doi: 10.1038/nm.3964
– volume: 6
  start-page: 63
  year: 1951
  ident: 10033_CR5
  publication-title: Rec. Prog. Horm. Res.
– volume: 100
  start-page: 1468
  year: 2013
  ident: 10033_CR19
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2013.07.1978
– volume: 36
  start-page: 157
  year: 2016
  ident: 10033_CR82
  publication-title: Nan Fang Yi Da Xue Xue Bao
– volume: 17
  year: 2016
  ident: 10033_CR83
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1023-z
– volume: 22
  start-page: 411
  year: 2004
  ident: 10033_CR54
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt950
– volume: 6
  year: 2016
  ident: 10033_CR33
  publication-title: Sci. Rep.
  doi: 10.1038/srep28218
– ident: 10033_CR44
– volume: 488
  start-page: 522
  year: 2012
  ident: 10033_CR88
  publication-title: Nature
  doi: 10.1038/nature11287
– volume: 98
  start-page: 3
  year: 2012
  ident: 10033_CR92
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2012.05.005
– volume: 10
  year: 2015
  ident: 10033_CR25
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0139824
– volume: 25
  start-page: 1408
  year: 2017
  ident: 10033_CR35
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2017.04.019
– volume: 18
  start-page: 413
  year: 2012
  ident: 10033_CR16
  publication-title: Nat. Med.
  doi: 10.1038/nm.2669
– volume: 104
  start-page: 49
  year: 1984
  ident: 10033_CR73
  publication-title: Dev. Biol.
  doi: 10.1016/0012-1606(84)90035-6
– volume: 273
  start-page: 5858
  year: 1998
  ident: 10033_CR76
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.10.5858
– volume: 11
  start-page: 631
  year: 2009
  ident: 10033_CR12
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1869
– volume: 339
  start-page: 538
  year: 1989
  ident: 10033_CR47
  publication-title: Nature
  doi: 10.1038/339538a0
– volume: 79
  start-page: 159
  year: 2010
  ident: 10033_CR13
  publication-title: Differentiation
  doi: 10.1016/j.diff.2010.01.001
– volume: 109
  start-page: 12580
  year: 2012
  ident: 10033_CR36
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1206600109
– volume: 103
  start-page: 8090
  year: 2006
  ident: 10033_CR72
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0601083103
– volume: 21
  start-page: 1116
  year: 2015
  ident: 10033_CR37
  publication-title: Nat. Med.
  doi: 10.1038/nm.3775
– volume: 33
  start-page: 410
  year: 2015
  ident: 10033_CR78
  publication-title: Semin. Reprod. Med.
  doi: 10.1055/s-0035-1567826
– volume: 22
  start-page: 457
  year: 2016
  ident: 10033_CR34
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gaw030
– volume: 41
  start-page: 675
  year: 1999
  ident: 10033_CR58
  publication-title: Dev. Growth Differ.
  doi: 10.1046/j.1440-169x.1999.00474.x
– volume: 105
  start-page: 14976
  year: 2008
  ident: 10033_CR67
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0807297105
– volume: 21
  issue: Supplement
  year: 2014
  ident: 10033_CR20
  publication-title: Reprod. Sci.
– volume: 418
  start-page: 293
  year: 2002
  ident: 10033_CR42
  publication-title: Nature
  doi: 10.1038/nature00927
– ident: 10033_CR81
– volume: 328
  start-page: 1561
  year: 2010
  ident: 10033_CR4
  publication-title: Science
  doi: 10.1126/science.1185473
– volume: 93
  start-page: 2594
  year: 2010
  ident: 10033_CR79
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2009.12.053
– volume: 74
  start-page: 119
  year: 2006
  ident: 10033_CR91
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod.105.045591
– volume: 9
  year: 2014
  ident: 10033_CR61
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0103985
– volume: 65
  start-page: 1231
  year: 1987
  ident: 10033_CR8
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jcem-65-6-1231
– volume: 4
  year: 2014
  ident: 10033_CR23
  publication-title: Sci. Reports
  doi: 10.1038/srep05580
– volume: 20
  start-page: 525
  year: 2004
  ident: 10033_CR75
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev.cellbio.19.111301.155141
– volume: 93
  start-page: 189
  year: 1998
  ident: 10033_CR87
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81571-8
– ident: 10033_CR59
  doi: 10.1016/S0925-4773(02)00087-4
– volume: 93
  start-page: 139
  year: 2000
  ident: 10033_CR39
  publication-title: Mech. Dev.
  doi: 10.1016/S0925-4773(00)00283-5
– volume: 3
  year: 2003
  ident: 10033_CR43
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-3-1
– volume: 262
  start-page: 303
  year: 2003
  ident: 10033_CR64
  publication-title: Dev. Biol.
  doi: 10.1016/S0012-1606(03)00391-9
– volume: 449
  start-page: 1003
  year: 2007
  ident: 10033_CR52
  publication-title: Nature
  doi: 10.1038/nature06196
– volume: 100
  start-page: 1451
  year: 2013
  ident: 10033_CR18
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2013.06.036
– volume: 437
  start-page: 894
  year: 2005
  ident: 10033_CR51
  publication-title: Nature
  doi: 10.1038/nature03994
– volume: 38
  start-page: 1430
  year: 2006
  ident: 10033_CR65
  publication-title: Nat. Genet.
  doi: 10.1038/ng1919
– volume: 8
  start-page: 966
  year: 2013
  ident: 10033_CR17
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.047
– volume: 25
  start-page: 243
  year: 2007
  ident: 10033_CR69
  publication-title: Semin. Reprod. Med.
  doi: 10.1055/s-2007-980218
– volume: 11
  start-page: 659
  year: 2004
  ident: 10033_CR40
  publication-title: Fertil. Steril.
– volume: 161
  start-page: 61
  year: 2016
  ident: 10033_CR84
  publication-title: Bull. Exp. Biol. Med.
  doi: 10.1007/s10517-016-3345-y
– volume: 21
  start-page: 469
  year: 1961
  ident: 10033_CR94
  publication-title: J. Endocrinol.
  doi: 10.1677/joe.0.0210469
– volume: 134
  start-page: 3401
  year: 2007
  ident: 10033_CR66
  publication-title: Development
  doi: 10.1242/dev.001107
– volume: 24
  start-page: 1505
  year: 2006
  ident: 10033_CR90
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2005-0580
– volume: 22
  start-page: 1612
  year: 2015
  ident: 10033_CR31
  publication-title: Reprod. Sci.
  doi: 10.1177/1933719115612137
– volume: 383
  year: 2014
  ident: 10033_CR22
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)60308-1
– volume: 22
  start-page: 316
  year: 2016
  ident: 10033_CR89
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gaw015
– volume: 8
  year: 2015
  ident: 10033_CR28
  publication-title: J. Ovarian Res.
  doi: 10.1186/s13048-015-0184-9
– volume: 20
  start-page: 7
  year: 2013
  ident: 10033_CR62
  publication-title: Reprod. Sci.
  doi: 10.1177/1933719112462632
– volume: 3
  start-page: 931
  year: 2002
  ident: 10033_CR1
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg952
– volume: 91
  start-page: 12258
  year: 1994
  ident: 10033_CR9
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.25.12258
– volume: 7
  start-page: 1233
  year: 2004
  ident: 10033_CR48
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1340
– volume: 91
  start-page: 11298
  year: 1994
  ident: 10033_CR55
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.24.11298
– volume: 9
  start-page: 339
  year: 2010
  ident: 10033_CR70
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.2.10447
– volume: 4
  start-page: 244
  year: 1997
  ident: 10033_CR85
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3300379
– volume: 316
  start-page: 404
  year: 2007
  ident: 10033_CR2
  publication-title: Science
  doi: 10.1126/science.1137741
– volume: 20
  start-page: 551
  year: 1987
  ident: 10033_CR6
  publication-title: Cell Tiss. Kinet.
– volume: 329
  start-page: 1667
  year: 2010
  ident: 10033_CR50
  publication-title: Science
  doi: 10.1126/science.1191996
– volume: 8
  year: 2012
  ident: 10033_CR60
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002575
– volume: 5
  start-page: 1705
  year: 1998
  ident: 10033_CR86
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3300784
– volume: 21
  start-page: 1114
  year: 2015
  ident: 10033_CR38
  publication-title: Nat. Med.
  doi: 10.1038/nm.3966
– volume: 440
  start-page: 1199
  year: 2006
  ident: 10033_CR68
  publication-title: Nature
  doi: 10.1038/nature04697
– volume: 103
  start-page: 3258
  year: 2004
  ident: 10033_CR49
  publication-title: Blood
  doi: 10.1182/blood-2003-11-4011
SSID ssj0000529419
Score 2.3781395
Snippet Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can differentiate into oocytes that fertilize to produce...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 10011
SubjectTerms 14
14/34
38
38/77
631/136
631/80
Animals
Cell Differentiation
Cre recombinase
Female
Fertility
Ganciclovir
Germ cells
Herpes simplex
Humanities and Social Sciences
Kinases
Mammals
Meiosis
Mice, Transgenic
multidisciplinary
Offspring
Oocytes
Oocytes - physiology
Oogonial Stem Cells - physiology
Ovaries
Ovary - physiology
Reporter gene
Reproductive status
Retinoic acid
Rodents
Science
Science (multidisciplinary)
Stem cell transplantation
Stem cells
Suicide
Suicide genes
Thymidine
Thymidine kinase
Transgenic mice
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEA4-ELyIb1dXieBNi33keRIRRQQ9KeytpE2KC0u7uquw_96Z9KHrotdN0m37TTNfZpJvCDkrQiUzYWVQCB1htMoGJkxYwKyxWqhccIcZ3ccncf_CHgZ80ATcJs22ynZO9BO1rXKMkV9Gmkug1rB6uBq_BVg1CrOrTQmNZbKK0mVo1XIguxgLZrFYpJuzMmGiLifgr_BMGUzNkS9jJub90QLJXNwr-Sth6v3Q3SbZaAgkva4R3yJLrtwma3VJydkOeUMdaWiik3qDIB2WFCvO09p3jWYUU7a0qvIZkEw69oKvztL6uCL1chyodEynFa0-YSFtSoq-D_GjprTUK4HCDRS4IRs5_C55ubt9vrkPmrIKQQ70bBrAtCIs0AjBMuFcZmKlskxFDrhaXjitAFUZe6LlEuY4uCtRcJ5rmceRMADnHlkpq9IdEMoUrHcs-EGdMAb9dcZsEVpRJIabQokeidqXm-aN5jiWvhilPvedqLQGJAVAUg9ICmPOuzHjWnHj3979FrO0-fom6bet9Mhp1wzfDSZDTOmqD-yTMKy0HOoe2a8h7v4OfuecSxgt58DvOqAm93xLOXz12twwDF4eXPOiNZMft_XnUxz-_xRHZD1Gk8VQdtgnK9P3D3cMXGianXiD_wKpigek
  priority: 102
  providerName: ProQuest
– databaseName: HAS SpringerNature Open Access 2022
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LSwMxEA5qEbyIb-uLCN50cR9JNjkWsZSCXlTwtmQ3WSyU3Wqr0H_vTPaBtSp4bWbaNF-SmWQm3xBykfsyToWJvVyoAG-rjKf9iHnMaKOEzAS3GNG9uxeDJzZ85s8rJGzewrikfUdp6bbpJjvsegqGBh-DwZ4auPpjYpV0kKod5nan1xs-DNubFYxdsUDVL2T8SP6gvGiFllzL5QzJb2FSZ336W2Szdhtpr-roNlmxxQ5ZrwpJznfJK7JHQxOdVmmBdFRQrDNPK4s1nlMM1NKyzObgWtKJo3m1hlaPFKkj4UB-YzorafkBx2ddULR4iBrVhaFusKADOaZho-e-R576t483A68upuBl4JTNPNhMhAHnQbBUWJvqUMo0lYEFDy3LrZKAZRw698pGzHIwUiLnPFNxFgZCA4j7ZK0oC3tIKJNwyjFg_VTEGMirlJncNyKPNNe5FF0SNIObZDXTOBa8GCcu4h3JpAIkAUASB0gCOpetzqTi2fhT-qTBLKnX3DQJFI_h8AXnyy45b5thtWAIRBe2fEeZiGF9ZV91yUEFcftz8DnnPAbteAH8VgCZuBdbitGLY-QGNRg8-M6rZpp86dav_-Lof-LHZCPEKYwX2v4JWZu9vdtT8Ihm6Vm9BD4BgLEGvw
  priority: 102
  providerName: Springer Nature
Title Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility
URI https://link.springer.com/article/10.1038/s41598-017-10033-6
https://www.ncbi.nlm.nih.gov/pubmed/28855574
https://www.proquest.com/docview/1957753104
https://www.proquest.com/docview/1934288309
https://pubmed.ncbi.nlm.nih.gov/PMC5577229
Volume 7
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED_tQ0i8IL4pjMpIvEEgafz5gFCpNk2VNiGgUt8iJ3bEpCrZ1m5a_3vu7KSibPDAU6TYThzfOfc7n_07gLd1qlUpnUpqaTJarXKJTXOecGedkbqSwlNE9-RUHs_4dC7mO9CnO-oGcHmna0f5pGaXiw83F-vPOOE_xSPj-uMSjRAdFMP_bRZyk8ld2EfLpCijwUkH9yPX98jwzHRnZ-5uSuzAWgshFN82Vbfw5-1tlH_EUoOJOnoIDzpsycZRGR7Bjm8ew72YbXL9BC6IYhqL2DLuHWRnDaNk9CyatcWaUTSXtW21RvzJzgMXrHcsnmRkgamDSJDZqmXtNfrYtmFkFkm0zDaOBZJQ7EBNe7UJ3j-F2dHhj8lx0mVcSCpEbqsE_zjSIcKQvJTelxZHoix15hHGVbU3GgWuRgGD-Zx7gZZM1kJURlWjTFqU9DPYa9rGvwDGNbpCDk2kyTnH-qbkrk6drHMrbK3lALJ-cIuqoyOnrBiLIoTFc11E2RQomyLIpsA27zZtziMZxz9rH_QyK3q9KjIjFHpo6IQO4M2mGKcUxUls49srqpNzSsKcmgE8jyLevK7XjQGoLeFvKhBd93ZJc_Yz0HZjMxw8fOb7Xk1-69Zfv-Llf7_oFdwfkWLTAnh6AHuryyv_GhHUqhzCrpqrIeyPx9PvU7x-OTz9-g3vTuRkGFYlhmHi_AI90x4M
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgQXxJuFAkaCE0TNw3bsA0IIqLb0cWqlvRkndkSlKtmyW9D-KX4jM3YSWCp66zW2k9gz9jfjsb8BeNWkqqykK5NG6ox2q1xi04In3Fmnpaql8BTRPTiU02P-ZSZmG_BruAtDxyqHNTEs1K6raY98O9OiRNMavYf387OEskZRdHVIoRHVYs-vfqLLtni3-wnl-zrPdz4ffZwmfVaBpEbrZJngrJIOUVTySnpf2VypqlKZR1OlbrxW2KkyD3aGL7gXuFrLRohal3WeSYu9wfdeg-sIvCk5e-WsHPd0KGrGM93fzUkLtb1AfKQ7bAgFWUibJtfx74JRe_Fs5j8B2oB7O3fgdm-wsg9Rw-7Chm_vwY2YwnJ1H86ItxqL2CIeSGQnLaMM9yxi5emKUYiYdV29QqOWzQPBrHcsXo9kgf6DmJXZsmPdD3TcbcsIa0lfmG0dC8yj-AMNHQAnn-EBHF_JgD-EzbZr_WNgXKF_5RB3dcE51tcVd03qZFNYYRslJ5ANg2vqnuOcUm2cmhBrL5SJAjEoEBMEYrDNm7HNPDJ8XFp7a5CZ6Wf7wvzRzQm8HItxnlLwxba-O6c6BafMzqmewKMo4vFz-FwIUWLrck34YwXiAF8vaU--BS5wbIaDh-98O6jJX7_13148ubwXL-Dm9Ohg3-zvHu49hVs5qS9to6dbsLn8fu6foR22rJ4H5Wfw9apn22_OHkNZ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9QwDLfGTSBeEN8cDAgSPEF1_UjS5AEhYDttDE4TYtLeStqkYtLU3rgb6P41_jrspC0cE3vba5O0TWzHduz8DPC8jlVeSptHtdQJnVbZyMQZj7g1VktVSeEoovtpJncP-YcjcbQBv_q7MJRW2e-JfqO2bUVn5JNEixxNa_QeJnWXFnGwPX0zP42oghRFWvtyGoFF9t3qJ7pvi9d720jrF2k63fnyfjfqKgxEFVoqywglTFrUqJKX0rnSpEqVpUocmi1V7bTCCeaptzlcxp3AnVvWQlQ6r9JEGpwZvvcKbObkFY1g893O7ODzcMJDMTSe6O6mTpypyQK1Jd1oQ8WQ-CJqcl0bnjNxz2dq_hOu9VpwehNudOYrexv47RZsuOY2XA0FLVd34JRQrLGJLUJ6IjtuGNW7Z0FznqwYBYxZ21YrNHHZ3MPNOsvCZUnmwUAIZ5ktW9b-QDfeNIw0L3EPM41lHocUf6CmdHDyIO7C4aUs-T0YNW3jHgDjCr0ti1pYZ5xjf11yW8dW1pkRplZyDEm_uEXVIZ5T4Y2TwkfeM1UEghRIkMITpMAxL4cx84D3cWHvrZ5mRSf7i-IPp47h2dCMUkuhGNO49oz6ZJzqPMd6DPcDiYfP4XMhRI6j8zXiDx0IEXy9pTn-5pHBcRguHr7zVc8mf_3Wf2fx8OJZPIVrKGnFx73Z_iO4nhL30pl6vAWj5fcz9xiNsmX5pON-Bl8vW-B-A3Q-SPQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+studies+in+mice+directly+link+oocytes+produced+during+adulthood+to+ovarian+function+and+natural+fertility&rft.jtitle=Scientific+reports&rft.au=Wang%2C+Ning&rft.au=Satirapod%2C+Chonthicha&rft.au=Ohguchi%2C+Yasuyo&rft.au=Park%2C+Eun-Sil&rft.date=2017-08-30&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=7&rft_id=info:doi/10.1038%2Fs41598-017-10033-6&rft_id=info%3Apmid%2F28855574&rft.externalDocID=PMC5577229
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon