The impact of non-additive genetic associations on age-related complex diseases

• Published in: Nature communications Vol. 12; no. 1; pp. 2436 - 14
• Main Authors: Guindo-Martínez, Marta, Amela, Ramon, Bonàs-Guarch, Silvia, Puiggròs, Montserrat, Salvoro, Cecilia, Miguel-Escalada, Irene, Carey, Caitlin E., Cole, Joanne B., Rüeger, Sina, Atkinson, Elizabeth, Leong, Aaron, Sanchez, Friman, Ramon-Cortes, Cristian, Ejarque, Jorge, Palmer, Duncan S., Kurki, Mitja, Aragam, Krishna, Florez, Jose C., Badia, Rosa M., Mercader, Josep M., Torrents, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 45/43; 631/208/205/2138; 631/208/727/2000; Age; Age Factors; Age related diseases; Aging; Chromosomes; Disease - genetics; Gene Frequency; Genetic Predisposition to Disease - genetics; Genome, Human - genetics; Genome-wide association studies; Genome-Wide Association Study - methods; Genome-Wide Association Study - statistics & numerical data; Genomes; Genotype; Genotypes; Haplotypes; Humanities and Social Sciences; Humans; Loci; Model testing; multidisciplinary; Phenotype; Polymorphism, Single Nucleotide; Science; Science (multidisciplinary); X chromosomes

Genome-wide association studies (GWAS) are not fully comprehensive, as current strategies typically test only the additive model, exclude the X chromosome, and use only one reference panel for genotype imputation. We implement an extensive GWAS strategy, GUIDANCE, which improves genotype imputation...