Using a two-sample mendelian randomization analysis to explore the relationship between physical activity and Alzheimer’s disease

• Published in: Scientific reports Vol. 12; no. 1; pp. 12976 - 9
• Main Authors: Zhang, Bowen, Huang, Xiaowen, Wang, Xiliang, Chen, Xiaorui, Zheng, Caifang, Shao, Weihao, Wang, Gaili, Zhang, Weidong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.07.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 692/499; Alzheimer Disease - genetics; Alzheimer's disease; Epidemiology; Exercise; Genome-wide association studies; Genome-Wide Association Study; Heterogeneity; Humanities and Social Sciences; Humans; Mendelian Randomization Analysis; multidisciplinary; Neurodegenerative diseases; Physical activity; Pleiotropy; Polymorphism, Single Nucleotide; Science; Science (multidisciplinary); Sedentary behavior; Sensitivity analysis

Evidence from previous epidemiological studies on the effect of physical activity on the risk of Alzheimer’s disease (AD) is conflicting. We performed a two-sample Mendelian randomization analysis to verify whether physical activity is causally associated with AD. This study used two-sample Mendelia...