Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis - Asada, Shuhei; Goyama, Susumu; Inoue, Daichi; Shikata, Shiori; Takeda, Reina; Fukushima, Tsuyoshi; Yonezawa, Taishi; Fujino, Takeshi; Hayashi, Yasutaka; Kawabata, Kimihito Cojin; Fukuyama, Tomofusa; Tanaka, Yosuke; et al. (Nature communications, 2018)
Keywords: 13/31; 14/19; 38/109; 38/91; 45/15; 49/88; 631/208/176; 631/67/1990/283; 64/60; 82/29; 82/58; Animals; Bone Marrow - metabolism; Bone Marrow - pathology; Bone Marrow Transplantation; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Catalysis; Cells (biology); Core Binding Factor Alpha 2 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - metabolism; CRISPR-Cas Systems; Female; Gene Editing; Gene expression; Gene Expression Regulation, Leukemic; HEK293 Cells; HeLa Cells; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; HOXA gene; Humanities and Social Sciences; Humans; Interferon Regulatory Factors - genetics; Interferon Regulatory Factors - metabolism; Leukemia; Leukemia, Myeloid - genetics; Leukemia, Myeloid - metabolism; Leukemia, Myeloid - mortality; Leukemia, Myeloid - pathology; Male; Mice; Mice, Inbred C57BL; multidisciplinary; Mutation; Myeloid leukemia; Neoplasia; Neoplasms; Progenitor cells; Repressor Proteins - genetics; Repressor Proteins - metabolism; Runx1 protein; RUNX1 Translocation Partner 1 Protein - genetics; RUNX1 Translocation Partner 1 Protein - metabolism; Science; Science (multidisciplinary); Signal Transduction; Stem cells; Survival Analysis; Tumor suppressor genes; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Tumors; Ubiquitin Thiolesterase - genetics; Ubiquitin Thiolesterase - metabolism; Ubiquitination; Whole-Body Irradiation