Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes - Saenwongsa, Wipawee; Nithichanon, Arnone; Chittaganpitch, Malinee; Buayai, Kampaew; Kewcharoenwong, Chidchamai; Thumrongwilainet, Boonyarat; Butta, Patcharavadee; Palaga, Tanapat; Takahashi, Yoshimasa; Ato, Manabu; Lertmemongkolchai, Ganjana (Scientific reports, 2020)
Keywords: 13; 13/1; 13/21; 13/95; 38; 38/77; 631/250/590; 692/700/459/1748; Aged; Antibodies, Viral - immunology; Antibody Affinity - immunology; Antibody Formation - drug effects; Antibody response; Antidiabetics; Antigens; Avidity; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - immunology; Female; Glibenclamide; Glyburide - pharmacology; Glyburide - therapeutic use; Hemagglutination inhibition; Hemagglutination Inhibition Tests; Humanities and Social Sciences; Humans; Immunization; Immunoglobulin G; Immunoglobulin G - metabolism; Influenza; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H3N2 Subtype - drug effects; Influenza A Virus, H3N2 Subtype - immunology; Influenza B; Influenza B virus - drug effects; Influenza B virus - immunology; Influenza Vaccines - immunology; Interferon-alpha - pharmacology; Male; Mechanistic Target of Rapamycin Complex 1 - metabolism; Metformin; Metformin - pharmacology; Metformin - therapeutic use; Monocytes - drug effects; Monocytes - metabolism; multidisciplinary; Rapamycin; Science; Science (multidisciplinary); Seasons; Signal transduction; Signal Transduction - drug effects; TOR protein; Vaccination; Vaccines; Virion - drug effects; Virion - immunology; Virions; α-Interferon