The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis

• Published in: Cytokine & growth factor reviews Vol. 52; pp. 88 - 98
• Main Authors: Li, Jiao, Chen, Xiang, Lu, Lingyun, Yu, Xijie
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2020
• Subjects: Advanced Basic Science; Bone metabolism; Estrogen withdrawal; Marrow adipose tissue; Postmenopausal osteoporosis; RANKL; JNK; OPG; RANK; CTGF; NF-κB; MSCs; TZDs; GM-CSF; FSH; SOST; LepR; CMKLR1; IONPs; IL; ERα; Dio2; MAPK; Bone metabolism; PPARγ; FoxC2; FFAs; TRAF6; ROS; rMAT; PMOP; MAT; BMAs; UCP1; NFATc1; WAT; Postmenopausal osteoporosis; BMMs; OVX; DPP4; PtNPs; cMAT; Estrogen withdrawal; PRDM16; BMD; TGF-β; SNS; Runx2; Marrow adipose tissue; EVs; C/EBP alpha; PGC-1α; GNPs; AdipoR; PA; CYLD; FABP4; TNF-α; BAT; HSCs; thiazolidinediones; estrogen withdrawal; receptor-associated factor 6; gold nanoparticles; platinum nanoparticles; Bone marrow adipocytes; iron oxide nanoparticles; sclerostin; uncoupling protein 1; CCAAT-enhancer-binding protein α; white adipose tissue; estrogen receptor alpha; forkhead box C2; fatty acid binding protein 4; free fatty acids; cylindromatosis; mitogen-activated protein kinase; deiodinase 2; peroxisome proliferator-activator receptor gamma; adiponectin receptor; tumor growth factor beta; bone marrow mesenchymal cells; extracellular vesicles; brown adipose tissue; hematopoietic stem cells; bone mineral density; constitutive marrow adipose tissue; marrow adipose tissue; c-Jun N-terminal kinase; regulated marrow adipose tissue; nuclear factor-κB; connective tissue growth factor; bone metabolism; osteoprotegerin; bone marrow monocytes/macrophages; granulocyte/ macrophage colony stimulating factor; receptor activator of nuclear factor-κB ligand; postmenopausal osteoporosis; chemokine-like receptor 1; tumor necrosis factor alpha; reactive oxygen species; interleukin; follicle-stimulating hormone; paltimic acid; leptin receptor; sympathetic nervous system; nuclear factor of activated T cells 1; receptor activator of nuclear factor-κB; positive regulatory domain containing 16; peroxisome proliferator activated receptor gamma coactivator 1 alpha; runt-related transcript factor 2; dipeptidyl peptidase 4; ovariectomy

[Display omitted] •With an aging population, postmenopausal osteoporosis (PMOP) has become a global public health issue.•Abnormal expansion of marrow adipose tissue (MAT) plays a crucial role in the onset and progression of PMOP.•Emerging therapeutic methods targeting MAT are confirmed to be effecti...