Flagellin shifts 3D bronchospheres towards mucus hyperproduction

• Published in: Respiratory research Vol. 21; no. 1; pp. 1 - 222
• Main Authors: Sprott, Richard F, Ritzmann, Felix, Langer, Frank, Yao, Yiwen, Herr, Christian, Kohl, Yvonne, Tschernig, Thomas, Bals, Robert, Beisswenger, Christoph
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 26.08.2020; BioMed Central; BMC
• Subjects: Antibodies; Bacteria; Bacterial diseases; Bacterial infections; Basal cells; Bronchospheres; Cell differentiation; Chronic obstructive pulmonary disease; Cilia; Cystic fibrosis; Cytokines; Development and progression; Differentiation; Epithelial cells; Epithelium; Flagellin; Fluorescence; Fluorescence microscopy; Genetic aspects; Globular proteins; Goblet cells; Health aspects; Hyperplasia; Infections; Inflammation; Letter to the Editor; Lung diseases; Microscopy; Mucus; Obstructive lung disease; Organoids; PAMPs; Properties; Respiratory diseases; Respiratory tract; Respiratory tract diseases; Software; TLR2 protein; Toll-like receptors; Germany; United States > US

Abstract Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are associated with acute and chronic bacterial infections of the lung. Excessive differentiation of basal cells to mucus-producing goblet cells can result in mucus hyperproduction and loss of mucociliary clearance in the...