Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

• Published in: Diabetologia Vol. 63; no. 12; pp. 2628 - 2640
• Main Authors: Chareyron, Isabelle, Christen, Stefan, Moco, Sofia, Valsesia, Armand, Lassueur, Steve, Dayon, Loïc, Wollheim, Claes B., Santo Domingo, Jaime, Wiederkehr, Andreas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2020; Springer Nature B.V
• Subjects: Adaptation; Beta cells; Calcium signalling; Cell activation; Cell culture; Diabetes mellitus (non-insulin dependent); Electron transport; Energy metabolism; Glucose; Glucose metabolism; Glycerol; Glycolysis; Human Physiology; Insulin; Insulin secretion; Intermediates; Internal Medicine; Islet cells; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Metabolites; Metabolomics; Mitochondria; Nutrients; Pancreas; Pentose phosphate pathway; Pyruvic acid; Respiration; Secretion; Signal transduction; Tricarboxylic acid cycle; Beta cells; Metabolomics; Human islets; Mitochondria; Calcium

Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells during chronic glucose stress. Methods Respiratio...