Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue

• Published in: Nature communications Vol. 12; no. 1; pp. 7035 - 16
• Main Authors: Ma, Yiyi, Dammer, Eric B., Felsky, Daniel, Duong, Duc M., Klein, Hans-Ulrich, White, Charles C., Zhou, Maotian, Logsdon, Benjamin A., McCabe, Cristin, Xu, Jishu, Wang, Minghui, Wingo, Thomas S., Lah, James J., Zhang, Bin, Schneider, Julie, Allen, Mariet, Wang, Xue, Ertekin-Taner, Nilüfer, Seyfried, Nicholas T., Levey, Allan I., Bennett, David A., De Jager, Philip L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 38; 38/91; 631/337/2019; 631/378/1689/1283; 631/378/340; 631/45/500; 82/58; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Atlases as Topic; Brain; Brain - metabolism; Brain - pathology; Brain Chemistry; Cognitive ability; Dementia disorders; Editing; Gene expression; Gene Expression Profiling; Genomes; Humanities and Social Sciences; Humans; Hydroxysteroid Dehydrogenases - genetics; Hydroxysteroid Dehydrogenases - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; multidisciplinary; Neurodegenerative diseases; Nucleotide sequence; ORAI2 Protein - genetics; ORAI2 Protein - metabolism; Perturbation; Phosphofructokinase-1, Type C - genetics; Phosphofructokinase-1, Type C - metabolism; Proteins; Proteomes; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; RNA - genetics; RNA - metabolism; RNA Editing; Science; Science (multidisciplinary); Superoxide dismutase; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Synaptotagmins - genetics; Synaptotagmins - metabolism; Transcriptome; Transcriptomes; Transcriptomics

RNA editing is a feature of RNA maturation resulting in the formation of transcripts whose sequence differs from the genome template. Brain RNA editing may be altered in Alzheimer’s disease (AD). Here, we analyzed data from 1,865 brain samples covering 9 brain regions from 1,074 unrelated subjects o...