Endometrial microbiota is more diverse in people with endometriosis than symptomatic controls

• Published in: Scientific reports Vol. 11; no. 1; p. 18877
• Main Authors: Wessels, Jocelyn M., Domínguez, Miguel A., Leyland, Nicholas A., Agarwal, Sanjay K., Foster, Warren G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/2565/2134; 692/699/2732; Adult; Biopsy; Case-Control Studies; DNA, Bacterial - isolation & purification; Dysbiosis - complications; Dysbiosis - diagnosis; Dysbiosis - microbiology; Dysbiosis - pathology; Endometriosis; Endometriosis - microbiology; Endometriosis - pathology; Endometrium; Endometrium - microbiology; Endometrium - pathology; Estrogens; Etiology; Female; Gynecology; Humanities and Social Sciences; Humans; Menstruation; Microbiota; multidisciplinary; Relative abundance; RNA, Ribosomal, 16S - genetics; rRNA 16S; Science; Science (multidisciplinary); Taxa; Uterus

Endometriosis is a chronic, estrogen-dependent gynecological condition affecting approximately 10% of reproductive age women. The most widely accepted theory of its etiology includes retrograde menstruation. Recent reports suggest the uterus is not sterile. Thus, the refluxed menstrual effluent may...