Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels

• Published in: Scientific reports Vol. 9; no. 1; pp. 16292 - 11
• Main Authors: Alharbi, Naif Khalaf, Qasim, Ibrahim, Almasoud, Abdulrahman, Aljami, Haya A., Alenazi, Mohamed W., Alhafufi, Ali, Aldibasi, Omar S., Hashem, Anwar M., Kasem, Samy, Albrahim, Raed, Aldubaib, Musaad, Almansour, Ali, Temperton, Nigel J., Kupke, Alexandra, Becker, Stephan, Abu-obaidah, Ali, Alkarar, Ali, Yoon, In-Kyu, Azhar, Esam, Lambe, Teresa, Bayoumi, Faisal, Aldowerij, Ali, Ibrahim, Osman H., Gilbert, Sarah C., Balkhy, Hanan H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.11.2019; Nature Publishing Group
• Subjects: 45; 45/77; 631/250/590; 631/326/596/2563; 64; 82; 96; 96/1; Adenoviridae - immunology; Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Camelidae; Camelus - immunology; Camelus - metabolism; Coronavirus Infections - prevention & control; Coronavirus Infections - veterinary; Coronavirus Infections - virology; Disease Outbreaks; Humanities and Social Sciences; Immunization; Immunogenicity; Middle East Respiratory Syndrome Coronavirus - immunology; Middle East Respiratory Syndrome Coronavirus - metabolism; Middle East Respiratory Syndrome Coronavirus - pathogenicity; Middle East Respiratory Syndrome Coronavirus - physiology; multidisciplinary; Science; Science (multidisciplinary); Spike protein; Vaccination; Vaccination - methods; Vaccines; Viral Vaccines - immunology; Viral Vaccines - pharmacology; Zoonoses - epidemiology

MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV inf...