Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels

MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV inf...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 9; no. 1; pp. 16292 - 11
Main Authors Alharbi, Naif Khalaf, Qasim, Ibrahim, Almasoud, Abdulrahman, Aljami, Haya A., Alenazi, Mohamed W., Alhafufi, Ali, Aldibasi, Omar S., Hashem, Anwar M., Kasem, Samy, Albrahim, Raed, Aldubaib, Musaad, Almansour, Ali, Temperton, Nigel J., Kupke, Alexandra, Becker, Stephan, Abu-obaidah, Ali, Alkarar, Ali, Yoon, In-Kyu, Azhar, Esam, Lambe, Teresa, Bayoumi, Faisal, Aldowerij, Ali, Ibrahim, Osman H., Gilbert, Sarah C., Balkhy, Hanan H.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.11.2019
Nature Publishing Group
Subjects
45
45/77
631/250/590
631/326/596/2563
64
82
96
96/1
Adenoviridae - immunology
Animals
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Camelidae
Camelus - immunology
Camelus - metabolism
Coronavirus Infections - prevention & control
Coronavirus Infections - veterinary
Coronavirus Infections - virology
Disease Outbreaks
Humanities and Social Sciences
Immunization
Immunogenicity
Middle East Respiratory Syndrome Coronavirus - immunology
Middle East Respiratory Syndrome Coronavirus - metabolism
Middle East Respiratory Syndrome Coronavirus - pathogenicity
Middle East Respiratory Syndrome Coronavirus - physiology
multidisciplinary
Science
Science (multidisciplinary)
Spike protein
Vaccination
Vaccination - methods
Vaccines
Viral Vaccines - immunology
Viral Vaccines - pharmacology
Zoonoses - epidemiology
Online AccessGet full text

Cover

Abstract MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.
AbstractList MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.
MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.
ArticleNumber 16292
Author Alharbi, Naif Khalaf
Aldubaib, Musaad
Temperton, Nigel J.
Bayoumi, Faisal
Aljami, Haya A.
Lambe, Teresa
Becker, Stephan
Hashem, Anwar M.
Gilbert, Sarah C.
Balkhy, Hanan H.
Alkarar, Ali
Ibrahim, Osman H.
Almasoud, Abdulrahman
Qasim, Ibrahim
Kasem, Samy
Aldowerij, Ali
Almansour, Ali
Alhafufi, Ali
Kupke, Alexandra
Yoon, In-Kyu
Abu-obaidah, Ali
Albrahim, Raed
Azhar, Esam
Alenazi, Mohamed W.
Aldibasi, Omar S.
Author_xml – sequence: 1
  givenname: Naif Khalaf
  surname: Alharbi
  fullname: Alharbi, Naif Khalaf
  email: harbina2@ngha.med.sa
  organization: Department of Infectious Disease Research, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences
– sequence: 2
  givenname: Ibrahim
  surname: Qasim
  fullname: Qasim, Ibrahim
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 3
  givenname: Abdulrahman
  surname: Almasoud
  fullname: Almasoud, Abdulrahman
  organization: Department of Infectious Disease Research, King Abdullah International Medical Research Center
– sequence: 4
  givenname: Haya A.
  surname: Aljami
  fullname: Aljami, Haya A.
  organization: Department of Infectious Disease Research, King Abdullah International Medical Research Center
– sequence: 5
  givenname: Mohamed W.
  surname: Alenazi
  fullname: Alenazi, Mohamed W.
  organization: Department of Infectious Disease Research, King Abdullah International Medical Research Center
– sequence: 6
  givenname: Ali
  surname: Alhafufi
  fullname: Alhafufi, Ali
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 7
  givenname: Omar S.
  surname: Aldibasi
  fullname: Aldibasi, Omar S.
  organization: Department of Bioinformatics and Biostatistics, King Abdullah International Medical Research Center
– sequence: 8
  givenname: Anwar M.
  orcidid: 0000-0002-8471-7011
  surname: Hashem
  fullname: Hashem, Anwar M.
  organization: Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University
– sequence: 9
  givenname: Samy
  surname: Kasem
  fullname: Kasem, Samy
  organization: Ministry of Environment, Water and Agriculture (MEWA), Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University
– sequence: 10
  givenname: Raed
  surname: Albrahim
  fullname: Albrahim, Raed
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 11
  givenname: Musaad
  surname: Aldubaib
  fullname: Aldubaib, Musaad
  organization: College of Agriculture and Veterinary Medicine, Qassim University
– sequence: 12
  givenname: Ali
  surname: Almansour
  fullname: Almansour, Ali
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 13
  givenname: Nigel J.
  orcidid: 0000-0002-7978-3815
  surname: Temperton
  fullname: Temperton, Nigel J.
  organization: Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent
– sequence: 14
  givenname: Alexandra
  surname: Kupke
  fullname: Kupke, Alexandra
  organization: Institute of Virology, Philipps University of Marburg, German Center for Infection Research (DZIF)
– sequence: 15
  givenname: Stephan
  surname: Becker
  fullname: Becker, Stephan
  organization: Institute of Virology, Philipps University of Marburg, German Center for Infection Research (DZIF)
– sequence: 16
  givenname: Ali
  surname: Abu-obaidah
  fullname: Abu-obaidah, Ali
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 17
  givenname: Ali
  surname: Alkarar
  fullname: Alkarar, Ali
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 18
  givenname: In-Kyu
  surname: Yoon
  fullname: Yoon, In-Kyu
  organization: International Vaccine Institute
– sequence: 19
  givenname: Esam
  surname: Azhar
  fullname: Azhar, Esam
  organization: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University
– sequence: 20
  givenname: Teresa
  surname: Lambe
  fullname: Lambe, Teresa
  organization: The Jenner Institute, University of Oxford
– sequence: 21
  givenname: Faisal
  surname: Bayoumi
  fullname: Bayoumi, Faisal
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 22
  givenname: Ali
  surname: Aldowerij
  fullname: Aldowerij, Ali
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 23
  givenname: Osman H.
  surname: Ibrahim
  fullname: Ibrahim, Osman H.
  organization: Ministry of Environment, Water and Agriculture (MEWA)
– sequence: 24
  givenname: Sarah C.
  orcidid: 0000-0002-6823-9750
  surname: Gilbert
  fullname: Gilbert, Sarah C.
  organization: The Jenner Institute, University of Oxford
– sequence: 25
  givenname: Hanan H.
  surname: Balkhy
  fullname: Balkhy, Hanan H.
  organization: Department of Infectious Disease Research, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Department of Infection Prevention and Control, Ministry of National Guard - Health Affairs
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31705137$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtP3DAUha0KVB7lD3RRWWLTTcCvJM6mEhqGh0SFVNpuLce5HjxKbLCTqvPv62F4lQXe2Lo-595z9e2hLR88IPSZkiNKuDxOgpaNLAhtipLVnBTiA9plRJQF44xtvXrvoIOUliSfkjWCNh_RDqc1KSmvd9HyYhpC1D2-HIbJhwV4Z9y4wtp3eG6tM9qscLBY4xvnFz3g05BgXZjdnnTXfyn-Pv9xg39rY5wHPMs21-kRsPP4NIYBOh1XuTxAnz6hbav7BAeP9z76dTb_Obsorq7PL2cnV4UpBRkLSQnrNDetJcLSBlirqZWtNIRADaITVSMrw2smiWyFrXTTMk6pMKQipmOW76Nvm753U5sDGPBjXlDdRTfkMCpop_7_8e5WLcIfVUlBa85yg6-PDWK4nyCNanDJQN9rD2FKKo_jXApJZZYevpEuwxR9Xu9BRaoms8mqL68TPUd5wpAFbCMwMaQUwT5LKFFr3GqDW2Xc6gG3Etkk35gyOT26sN7K9e9b-caa8hy_gPgS-x3XP0a9vTo
CitedBy_id crossref_primary_10_3390_vaccines10070993
crossref_primary_10_1007_s40121_020_00300_x
crossref_primary_10_1016_S1473_3099_20_30317_0
crossref_primary_10_1186_s12929_020_00695_2
crossref_primary_10_3390_microorganisms9010042
crossref_primary_10_3390_vaccines8040634
crossref_primary_10_3389_fimmu_2020_602256
crossref_primary_10_3389_fimmu_2020_01651
crossref_primary_10_1111_cei_13517
crossref_primary_10_3390_v13020217
crossref_primary_10_1038_s41541_021_00315_6
crossref_primary_10_1016_S2214_109X_23_00117_1
crossref_primary_10_32415_jscientia_2020_6_6_41_80
crossref_primary_10_1186_s42522_022_00068_9
crossref_primary_10_3390_v12111215
crossref_primary_10_3201_eid2709_203508
crossref_primary_10_3390_vaccines10081330
crossref_primary_10_1007_s40199_022_00446_8
crossref_primary_10_2174_0929867328666210521164809
crossref_primary_10_1016_j_jiph_2020_04_016
crossref_primary_10_1016_j_diagmicrobio_2020_115273
crossref_primary_10_1590_1678_4685_gmb_2022_0079
crossref_primary_10_1016_j_cell_2020_08_026
crossref_primary_10_3201_eid2906_230128
crossref_primary_10_3389_fimmu_2022_1063679
crossref_primary_10_3390_vetsci8080156
crossref_primary_10_1111_cbdd_13761
crossref_primary_10_1016_S2666_5247_24_00082_X
crossref_primary_10_1177_03009858211069120
crossref_primary_10_3390_vaccines9101052
crossref_primary_10_1128_mSphere_00203_20
crossref_primary_10_3390_genes13122355
crossref_primary_10_4110_in_2020_20_e28
crossref_primary_10_1016_j_trsl_2021_11_007
crossref_primary_10_1016_j_bios_2024_116423
crossref_primary_10_3389_fimmu_2022_823949
crossref_primary_10_1128_mSphere_00219_21
crossref_primary_10_1016_j_tjog_2020_09_006
crossref_primary_10_1002_cti2_1345
crossref_primary_10_1016_S1473_3099_20_30160_2
crossref_primary_10_1097_JCMA_0000000000000461
crossref_primary_10_1111_tbed_13872
crossref_primary_10_1128_mBio_00554_20
crossref_primary_10_1128_JVI_01614_21
crossref_primary_10_1177_11786302241271545
crossref_primary_10_1186_s12917_023_03769_z
crossref_primary_10_1080_14760584_2020_1813574
crossref_primary_10_1080_21645515_2020_1787064
crossref_primary_10_1016_j_smim_2020_101430
crossref_primary_10_3389_fimmu_2023_1184362
crossref_primary_10_1016_j_phrs_2023_106699
crossref_primary_10_1371_journal_pone_0244415
crossref_primary_10_1007_s12275_022_1608_z
crossref_primary_10_1016_S2666_5247_21_00193_2
crossref_primary_10_3389_fimmu_2023_1205080
crossref_primary_10_1126_sciadv_aba8399
crossref_primary_10_3390_v12121370
crossref_primary_10_3390_nu14163417
crossref_primary_10_1016_j_ymthe_2022_01_034
crossref_primary_10_1016_j_vaccine_2022_06_008
crossref_primary_10_1111_imcb_12419
crossref_primary_10_3390_ph14060511
crossref_primary_10_1007_s12275_022_1547_8
Cites_doi 10.1016/j.jiph.2017.09.022
10.1038/mt.2013.284
10.1128/JVI.00614-15
10.1126/science.aad1283
10.2807/1560-7917.ES2013.18.36.20574
10.1073/pnas.1718769115
10.1093/infdis/jiz137
10.3201/eid2012.141280
10.1002/rmv.1917
10.1038/nature10590
10.3201/eid2007.140571
10.2807/1560-7917.ES2014.19.23.20828
10.1038/nature12328
10.1016/j.ebiom.2018.02.011
10.3390/v10080425
10.1016/j.mex.2015.09.003
10.3201/eid2212.160382
10.1038/emi.2017.44
10.3389/fimmu.2019.01677
10.1016/j.vaccine.2017.05.032
10.1016/j.phrp.2015.08.006
10.1038/s41541-017-0029-1
10.3389/fmicb.2019.01781
10.1016/j.jiph.2018.01.004
10.1080/14760584.2018.1506702
10.3201/eid2008.140596
10.3201/eid2008.140590
10.3201/eid2004.131746
10.1371/journal.pone.0040385
10.1111/ina.12430
10.2807/ese.17.39.20285-en
10.1038/emi.2017.89
10.1038/emi.2016.130
10.1128/mBio.01985-18
10.1056/NEJMoa1401505
10.3201/eid2510.190051
10.1016/S1473-3099(13)70164-6
10.1371/journal.pone.0140125
10.1038/nature12005
10.2807/1560-7917.ES.2017.22.13.30498
10.1038/nm.1850
10.3201/eid2012.141026
10.1038/srep20617
10.1016/j.jim.2019.01.005
ContentType Journal Article
Copyright The Author(s) 2019
2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2019
– notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
COVID
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/s41598-019-52730-4
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
Coronavirus Research Database
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
Coronavirus Research Database
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database

MEDLINE
MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 11
ExternalDocumentID PMC6841732
31705137
10_1038_s41598_019_52730_4
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AARCD
COVID
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c540t-8102da3cbf04f19e2ba1f8b8c00e7e4d46986c372808b4f6a9b23114c060cd2f3
IEDL.DBID M48
ISSN 2045-2322
IngestDate Thu Aug 21 14:04:59 EDT 2025
Fri Jul 11 01:21:18 EDT 2025
Wed Aug 13 11:26:33 EDT 2025
Thu Apr 03 06:52:26 EDT 2025
Thu Apr 24 23:44:06 EDT 2025
Tue Jul 01 00:56:05 EDT 2025
Fri Feb 21 02:38:33 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-8102da3cbf04f19e2ba1f8b8c00e7e4d46986c372808b4f6a9b23114c060cd2f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-8471-7011
0000-0002-7978-3815
0000-0002-6823-9750
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41598-019-52730-4
PMID 31705137
PQID 2313069273
PQPubID 2041939
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6841732
proquest_miscellaneous_2313384818
proquest_journals_2313069273
pubmed_primary_31705137
crossref_primary_10_1038_s41598_019_52730_4
crossref_citationtrail_10_1038_s41598_019_52730_4
springer_journals_10_1038_s41598_019_52730_4
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-11-08
PublicationDateYYYYMMDD 2019-11-08
PublicationDate_xml – month: 11
  year: 2019
  text: 2019-11-08
  day: 08
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Hemida, M. G. et al. Seroepidemiology of middle east respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity. Eurosurveillance, https://doi.org/10.2807/1560-7917.ES2014.19.23.20828 (2014).
LuGMolecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26Nature2013500227311:CAS:528:DC%2BC3sXhtVKhtbfK2013Natur.500..227L10.1038/nature12328238316477095341
Reusken, C. B. E. M. et al. Geographic distribution of MERS coronavirus among dromedary camels, Africa. Emerg. Infect. Dis., https://doi.org/10.3201/eid2008.140590 (2014).
YusofMFDiversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab EmiratesEmerg. Microbes Infect.201761:CAS:528:DC%2BC2sXhslOnur7J10.1038/emi.2017.89291162175717090
ReuskenCBEMMiddle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological studyLancet. Infect. Dis.201313859661:CAS:528:DC%2BC3sXht1Ggt7nM10.1016/S1473-3099(13)70164-6239330677106530
MunsterVJProtective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse modelNPJ Vaccines2017210.1038/s41541-017-0029-1292638835643297
Warimwe, G. M. et al. Chimpanzee adenovirus vaccine provides multispecies protection against rift valley fever. Sci. Rep. 6 (2016).
Coughlan, L. et al. Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults. EbioMedicine, https://doi.org/10.1016/j.ebiom.2018.02.011 (2018).
AliMASystematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in EgyptEmerg. Microbes Infect.2017610.1038/emi.2016.130280500215285495
ZhouYJiangSDuLProspects for a MERS-CoV spike vaccineExpert Rev. Vaccines2018176776861:CAS:528:DC%2BC1cXhsV2isb3J10.1080/14760584.2018.1506702300584036355461
DeemSLSerological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, KenyaPLoS One201510e014012510.1371/journal.pone.0140125264737334608777
Kasem, S. et al. Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia. J. Infect. Public Health11, 331–338.
Miguel, E. et al. Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco, 2015. Euro Surveill. 22 (2017).
Alharbi, N. K. et al. ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice, https://doi.org/10.1016/j.vaccine.2017.05.032 (2017).
Padilla-QuirarteHOLopez-GuerreroDVGutierrez-XicotencatlLEsquivel-GuadarramaFProtective Antibodies Against Influenza ProteinsFront. Immunol.201910167710.3389/fimmu.2019.01677313798666657620
HashemAMDevelopment and validation of different indirect ELISAs for MERS-CoV serological testingJ. Immunol. Methods201946641461:CAS:528:DC%2BC1MXhsVyjsLw%3D10.1016/j.jim.2019.01.005306598367094657
Corman, V. M. et al. Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerg. Infect. Dis., https://doi.org/10.3201/eid2008.140596 (2014).
HaagmansBLAn orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camelsScience (80-.).201635177811:CAS:528:DC%2BC2MXitV2nt7nK2016Sci...351...77H10.1126/science.aad1283
YongCYOngHKYeapSKHoKLTanWSRecent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-CoronavirusFront. Microbiol.201910178110.3389/fmicb.2019.01781314280746688523
Meyer, B. et al. Antibodies against MERS coronavirus in dromedaries, United Arab Emirates, 2003 and 2013. Emerg. Infect. Dis., https://doi.org/10.3201/eid2004.131746 (2014).
Conzade, R. et al. Reported Direct and Indirect Contact with Dromedary Camels among Laboratory-Confirmed MERS-CoV Cases. Viruses10 (2018).
MeyerBTime Course of MERS-CoV Infection and Immunity in Dromedary CamelsEmerg. Infect. Dis.2016222171217310.3201/eid2212.160382272243155189137
HemidaMGMERS coronavirus in dromedary camel herd, Saudi ArabiaEmerg. Infect. Dis.2014201231410.3201/eid2007.140571249641934073860
Hashem, A. M. et al. A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model. J. Infect. Dis., https://doi.org/10.1093/infdis/jiz137 (2019).
Müller, M. A. et al. Mers coronavirus neutralizing antibodies in camels, eastern Africa, 1983–1997. Emerg. Infect. Dis, https://doi.org/10.3201/eid2012.141026 (2014).
Korea Centers for Disease, C. & Prevention. Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea, 2015. Osong Public Heal. Res Perspect6, 269–278 (2015).
Perera, R. A. et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, june 2013. Eurosurveillance18 (2013).
Kasem, S. et al. The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons. J. Infect. Public Health, https://doi.org/10.1016/j.jiph.2018.01.004 (2018).
Perera, R. A. et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill18, pii=20574 (2013).
Alharbi, N. K. Vaccines against Middle East respiratory syndrome coronavirus for humans and camels. Rev Med Virol27 (2016).
Antrobus, R. D. et al. Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens. Mol. Ther., https://doi.org/10.1038/mt.2013.284 (2014).
Xiao, S., Li, Y., Sung, M., Wei, J. & Yang, Z. A study of the probable transmission routes of MERS-CoV during the first hospital outbreak in the Republic of Korea. Indoor Air, https://doi.org/10.1111/ina.12430 (2018).
WHO. MERS-CoV. (2019).
Okba, N. M. A. et al. Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections. Emerg. Infect. Dis. 25 (2019).
FalzaranoDDromedary camels in northern Mali have high seropositivity to MERS-CoVOne Heal. (Amsterdam, Netherlands)201734143
Chu, D. K. W. et al. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc. Natl. Acad. Sci. USA, https://doi.org/10.1073/pnas.1718769115 (2018).
DicksMDA novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicityPLoS One20127e403851:CAS:528:DC%2BC38XhtVyisrvN2012PLoSO...740385D10.1371/journal.pone.0040385228081493396660
Alshukairi, A. N. et al. High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia. Mbio, https://doi.org/10.1128/mBio.01985-18 (2018).
Volz, A. et al. Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein. J Virol, https://doi.org/10.1128/JVI.00614-15 (2015).
Grehan, K., Ferrara, F. & Temperton, N. An optimised method for the production of MERS-CoV spike expressing viral pseudotypes. MethodsX, https://doi.org/10.1016/j.mex.2015.09.003 (2015).
HemidaMGLongitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015Emerg. Microbes Infect.2017610.1038/emi.2017.44286343555520318
AzharEIEvidence for camel-to-human transmission of MERS coronavirusN Engl J Med2014370249925051:CAS:528:DC%2BC2cXhs1artLzN10.1056/NEJMoa140150524896817
Corman, V. M. et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Eurosurveillance, https://doi.org/10.2807/ese.17.39.20285-en (2012).
Lorch, J. M. et al. Experimental infection of bats with Geomyces destructans causes white-nose syndrome. Nature, https://doi.org/10.1038/nature10590 (2011).
AlagailiANMiddle East respiratory syndrome coronavirus infection in dromedary camels in Saudi ArabiaMBio20145e0088414245703703940034
RajVSDipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMCNature201349525141:CAS:528:DC%2BC3sXjvFensb8%3D2013Natur.495..251R10.1038/nature12005234860637095326
DraperSJEffective induction of high-titer antibodies by viral vector vaccinesNat Med2008148198211:CAS:528:DC%2BD1cXptlKlt7w%3D10.1038/nm.1850186608184822545
AdneyDRReplication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camelsEmerg Infect Dis201420199920051:CAS:528:DC%2BC28XitVOisLbJ10.3201/eid2012.141280254185294257817
52730_CR40
52730_CR44
52730_CR42
52730_CR3
52730_CR48
52730_CR4
AN Alagaili (52730_CR16) 2014; 5
52730_CR5
52730_CR24
52730_CR46
52730_CR45
Y Zhou (52730_CR22) 2018; 17
52730_CR1
B Meyer (52730_CR27) 2016; 22
52730_CR2
HO Padilla-Quirarte (52730_CR38) 2019; 10
MG Hemida (52730_CR28) 2014; 20
CY Yong (52730_CR23) 2019; 10
EI Azhar (52730_CR47) 2014; 370
BL Haagmans (52730_CR36) 2016; 351
SJ Draper (52730_CR43) 2008; 14
DR Adney (52730_CR41) 2014; 20
AM Hashem (52730_CR39) 2019; 466
52730_CR11
52730_CR33
CBEM Reusken (52730_CR6) 2013; 13
52730_CR10
MG Hemida (52730_CR26) 2017; 6
52730_CR30
52730_CR15
MA Ali (52730_CR25) 2017; 6
52730_CR37
52730_CR14
52730_CR13
52730_CR35
52730_CR12
52730_CR34
52730_CR19
52730_CR18
MD Dicks (52730_CR32) 2012; 7
52730_CR17
VS Raj (52730_CR21) 2013; 495
MF Yusof (52730_CR29) 2017; 6
52730_CR8
G Lu (52730_CR20) 2013; 500
VJ Munster (52730_CR31) 2017; 2
D Falzarano (52730_CR7) 2017; 3
SL Deem (52730_CR9) 2015; 10
References_xml – reference: RajVSDipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMCNature201349525141:CAS:528:DC%2BC3sXjvFensb8%3D2013Natur.495..251R10.1038/nature12005234860637095326
– reference: HemidaMGLongitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015Emerg. Microbes Infect.2017610.1038/emi.2017.44286343555520318
– reference: Corman, V. M. et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Eurosurveillance, https://doi.org/10.2807/ese.17.39.20285-en (2012).
– reference: FalzaranoDDromedary camels in northern Mali have high seropositivity to MERS-CoVOne Heal. (Amsterdam, Netherlands)201734143
– reference: LuGMolecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26Nature2013500227311:CAS:528:DC%2BC3sXhtVKhtbfK2013Natur.500..227L10.1038/nature12328238316477095341
– reference: HemidaMGMERS coronavirus in dromedary camel herd, Saudi ArabiaEmerg. Infect. Dis.2014201231410.3201/eid2007.140571249641934073860
– reference: ZhouYJiangSDuLProspects for a MERS-CoV spike vaccineExpert Rev. Vaccines2018176776861:CAS:528:DC%2BC1cXhsV2isb3J10.1080/14760584.2018.1506702300584036355461
– reference: AzharEIEvidence for camel-to-human transmission of MERS coronavirusN Engl J Med2014370249925051:CAS:528:DC%2BC2cXhs1artLzN10.1056/NEJMoa140150524896817
– reference: Kasem, S. et al. Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia. J. Infect. Public Health11, 331–338.
– reference: Corman, V. M. et al. Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerg. Infect. Dis., https://doi.org/10.3201/eid2008.140596 (2014).
– reference: MeyerBTime Course of MERS-CoV Infection and Immunity in Dromedary CamelsEmerg. Infect. Dis.2016222171217310.3201/eid2212.160382272243155189137
– reference: ReuskenCBEMMiddle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological studyLancet. Infect. Dis.201313859661:CAS:528:DC%2BC3sXht1Ggt7nM10.1016/S1473-3099(13)70164-6239330677106530
– reference: Conzade, R. et al. Reported Direct and Indirect Contact with Dromedary Camels among Laboratory-Confirmed MERS-CoV Cases. Viruses10 (2018).
– reference: HaagmansBLAn orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camelsScience (80-.).201635177811:CAS:528:DC%2BC2MXitV2nt7nK2016Sci...351...77H10.1126/science.aad1283
– reference: Perera, R. A. et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill18, pii=20574 (2013).
– reference: Lorch, J. M. et al. Experimental infection of bats with Geomyces destructans causes white-nose syndrome. Nature, https://doi.org/10.1038/nature10590 (2011).
– reference: Coughlan, L. et al. Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults. EbioMedicine, https://doi.org/10.1016/j.ebiom.2018.02.011 (2018).
– reference: Volz, A. et al. Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein. J Virol, https://doi.org/10.1128/JVI.00614-15 (2015).
– reference: Hemida, M. G. et al. Seroepidemiology of middle east respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity. Eurosurveillance, https://doi.org/10.2807/1560-7917.ES2014.19.23.20828 (2014).
– reference: AdneyDRReplication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camelsEmerg Infect Dis201420199920051:CAS:528:DC%2BC28XitVOisLbJ10.3201/eid2012.141280254185294257817
– reference: Grehan, K., Ferrara, F. & Temperton, N. An optimised method for the production of MERS-CoV spike expressing viral pseudotypes. MethodsX, https://doi.org/10.1016/j.mex.2015.09.003 (2015).
– reference: Chu, D. K. W. et al. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc. Natl. Acad. Sci. USA, https://doi.org/10.1073/pnas.1718769115 (2018).
– reference: Kasem, S. et al. The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons. J. Infect. Public Health, https://doi.org/10.1016/j.jiph.2018.01.004 (2018).
– reference: Korea Centers for Disease, C. & Prevention. Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea, 2015. Osong Public Heal. Res Perspect6, 269–278 (2015).
– reference: Hashem, A. M. et al. A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model. J. Infect. Dis., https://doi.org/10.1093/infdis/jiz137 (2019).
– reference: DeemSLSerological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, KenyaPLoS One201510e014012510.1371/journal.pone.0140125264737334608777
– reference: YusofMFDiversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab EmiratesEmerg. Microbes Infect.201761:CAS:528:DC%2BC2sXhslOnur7J10.1038/emi.2017.89291162175717090
– reference: Alshukairi, A. N. et al. High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia. Mbio, https://doi.org/10.1128/mBio.01985-18 (2018).
– reference: Xiao, S., Li, Y., Sung, M., Wei, J. & Yang, Z. A study of the probable transmission routes of MERS-CoV during the first hospital outbreak in the Republic of Korea. Indoor Air, https://doi.org/10.1111/ina.12430 (2018).
– reference: AliMASystematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in EgyptEmerg. Microbes Infect.2017610.1038/emi.2016.130280500215285495
– reference: Meyer, B. et al. Antibodies against MERS coronavirus in dromedaries, United Arab Emirates, 2003 and 2013. Emerg. Infect. Dis., https://doi.org/10.3201/eid2004.131746 (2014).
– reference: AlagailiANMiddle East respiratory syndrome coronavirus infection in dromedary camels in Saudi ArabiaMBio20145e0088414245703703940034
– reference: DraperSJEffective induction of high-titer antibodies by viral vector vaccinesNat Med2008148198211:CAS:528:DC%2BD1cXptlKlt7w%3D10.1038/nm.1850186608184822545
– reference: Antrobus, R. D. et al. Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens. Mol. Ther., https://doi.org/10.1038/mt.2013.284 (2014).
– reference: Müller, M. A. et al. Mers coronavirus neutralizing antibodies in camels, eastern Africa, 1983–1997. Emerg. Infect. Dis, https://doi.org/10.3201/eid2012.141026 (2014).
– reference: MunsterVJProtective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse modelNPJ Vaccines2017210.1038/s41541-017-0029-1292638835643297
– reference: Miguel, E. et al. Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco, 2015. Euro Surveill. 22 (2017).
– reference: Okba, N. M. A. et al. Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections. Emerg. Infect. Dis. 25 (2019).
– reference: Reusken, C. B. E. M. et al. Geographic distribution of MERS coronavirus among dromedary camels, Africa. Emerg. Infect. Dis., https://doi.org/10.3201/eid2008.140590 (2014).
– reference: Alharbi, N. K. et al. ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice, https://doi.org/10.1016/j.vaccine.2017.05.032 (2017).
– reference: Alharbi, N. K. Vaccines against Middle East respiratory syndrome coronavirus for humans and camels. Rev Med Virol27 (2016).
– reference: WHO. MERS-CoV. (2019).
– reference: Perera, R. A. et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, june 2013. Eurosurveillance18 (2013).
– reference: HashemAMDevelopment and validation of different indirect ELISAs for MERS-CoV serological testingJ. Immunol. Methods201946641461:CAS:528:DC%2BC1MXhsVyjsLw%3D10.1016/j.jim.2019.01.005306598367094657
– reference: Padilla-QuirarteHOLopez-GuerreroDVGutierrez-XicotencatlLEsquivel-GuadarramaFProtective Antibodies Against Influenza ProteinsFront. Immunol.201910167710.3389/fimmu.2019.01677313798666657620
– reference: YongCYOngHKYeapSKHoKLTanWSRecent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-CoronavirusFront. Microbiol.201910178110.3389/fmicb.2019.01781314280746688523
– reference: DicksMDA novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicityPLoS One20127e403851:CAS:528:DC%2BC38XhtVyisrvN2012PLoSO...740385D10.1371/journal.pone.0040385228081493396660
– reference: Warimwe, G. M. et al. Chimpanzee adenovirus vaccine provides multispecies protection against rift valley fever. Sci. Rep. 6 (2016).
– ident: 52730_CR5
  doi: 10.1016/j.jiph.2017.09.022
– ident: 52730_CR34
  doi: 10.1038/mt.2013.284
– ident: 52730_CR1
– ident: 52730_CR46
  doi: 10.1128/JVI.00614-15
– volume: 3
  start-page: 41
  year: 2017
  ident: 52730_CR7
  publication-title: One Heal. (Amsterdam, Netherlands)
– volume: 351
  start-page: 77
  year: 2016
  ident: 52730_CR36
  publication-title: Science (80-.).
  doi: 10.1126/science.aad1283
– ident: 52730_CR37
  doi: 10.2807/1560-7917.ES2013.18.36.20574
– ident: 52730_CR18
  doi: 10.1073/pnas.1718769115
– ident: 52730_CR44
  doi: 10.1093/infdis/jiz137
– volume: 20
  start-page: 1999
  year: 2014
  ident: 52730_CR41
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2012.141280
– ident: 52730_CR24
  doi: 10.1002/rmv.1917
– ident: 52730_CR3
  doi: 10.1038/nature10590
– volume: 20
  start-page: 1231
  year: 2014
  ident: 52730_CR28
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2007.140571
– ident: 52730_CR15
  doi: 10.2807/1560-7917.ES2014.19.23.20828
– volume: 500
  start-page: 227
  year: 2013
  ident: 52730_CR20
  publication-title: Nature
  doi: 10.1038/nature12328
– ident: 52730_CR35
  doi: 10.1016/j.ebiom.2018.02.011
– ident: 52730_CR4
  doi: 10.3390/v10080425
– ident: 52730_CR45
  doi: 10.1016/j.mex.2015.09.003
– volume: 22
  start-page: 2171
  year: 2016
  ident: 52730_CR27
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2212.160382
– volume: 6
  year: 2017
  ident: 52730_CR26
  publication-title: Emerg. Microbes Infect.
  doi: 10.1038/emi.2017.44
– volume: 10
  start-page: 1677
  year: 2019
  ident: 52730_CR38
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.01677
– ident: 52730_CR10
  doi: 10.2807/1560-7917.ES2013.18.36.20574
– ident: 52730_CR30
  doi: 10.1016/j.vaccine.2017.05.032
– ident: 52730_CR2
  doi: 10.1016/j.phrp.2015.08.006
– volume: 2
  year: 2017
  ident: 52730_CR31
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-017-0029-1
– volume: 10
  start-page: 1781
  year: 2019
  ident: 52730_CR23
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.01781
– ident: 52730_CR17
  doi: 10.1016/j.jiph.2018.01.004
– volume: 17
  start-page: 677
  year: 2018
  ident: 52730_CR22
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2018.1506702
– ident: 52730_CR13
  doi: 10.3201/eid2008.140596
– ident: 52730_CR14
  doi: 10.3201/eid2008.140590
– ident: 52730_CR11
  doi: 10.3201/eid2004.131746
– volume: 7
  start-page: e40385
  year: 2012
  ident: 52730_CR32
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0040385
– ident: 52730_CR42
  doi: 10.1111/ina.12430
– ident: 52730_CR48
  doi: 10.2807/ese.17.39.20285-en
– volume: 6
  year: 2017
  ident: 52730_CR29
  publication-title: Emerg. Microbes Infect.
  doi: 10.1038/emi.2017.89
– volume: 5
  start-page: e00884
  year: 2014
  ident: 52730_CR16
  publication-title: MBio
– volume: 6
  year: 2017
  ident: 52730_CR25
  publication-title: Emerg. Microbes Infect.
  doi: 10.1038/emi.2016.130
– ident: 52730_CR19
  doi: 10.1128/mBio.01985-18
– volume: 370
  start-page: 2499
  year: 2014
  ident: 52730_CR47
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1401505
– ident: 52730_CR40
  doi: 10.3201/eid2510.190051
– volume: 13
  start-page: 859
  year: 2013
  ident: 52730_CR6
  publication-title: Lancet. Infect. Dis.
  doi: 10.1016/S1473-3099(13)70164-6
– volume: 10
  start-page: e0140125
  year: 2015
  ident: 52730_CR9
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0140125
– volume: 495
  start-page: 251
  year: 2013
  ident: 52730_CR21
  publication-title: Nature
  doi: 10.1038/nature12005
– ident: 52730_CR8
  doi: 10.2807/1560-7917.ES.2017.22.13.30498
– volume: 14
  start-page: 819
  year: 2008
  ident: 52730_CR43
  publication-title: Nat Med
  doi: 10.1038/nm.1850
– ident: 52730_CR12
  doi: 10.3201/eid2012.141026
– ident: 52730_CR33
  doi: 10.1038/srep20617
– volume: 466
  start-page: 41
  year: 2019
  ident: 52730_CR39
  publication-title: J. Immunol. Methods
  doi: 10.1016/j.jim.2019.01.005
SSID ssj0000529419
Score 2.5236285
Snippet MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 16292
SubjectTerms 45
45/77
631/250/590
631/326/596/2563
64
82
96
96/1
Adenoviridae - immunology
Animals
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Camelidae
Camelus - immunology
Camelus - metabolism
Coronavirus Infections - prevention & control
Coronavirus Infections - veterinary
Coronavirus Infections - virology
Disease Outbreaks
Humanities and Social Sciences
Immunization
Immunogenicity
Middle East Respiratory Syndrome Coronavirus - immunology
Middle East Respiratory Syndrome Coronavirus - metabolism
Middle East Respiratory Syndrome Coronavirus - pathogenicity
Middle East Respiratory Syndrome Coronavirus - physiology
multidisciplinary
Science
Science (multidisciplinary)
Spike protein
Vaccination
Vaccination - methods
Vaccines
Viral Vaccines - immunology
Viral Vaccines - pharmacology
Zoonoses - epidemiology
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BERIXxJuUgozEDaLaseM4J1RttypIBYlStLfIr6hblaR0t1L33zOTZFMtFb3azsvf2DOZ8XwD8MHF2gXnEQFvQ6pyJ1KnjE5RF-go8KqyoHzno2_68ER9neWzweG2GI5VrvfEbqMOrScf-S7aIWjdlqhtP1_8SalqFEVXhxIa9-EBUZeRVBezYvSxUBRLiXLIleHS7C5QX1FOmShTYh7jqdrUR7eMzNtnJf8JmHZ66OAJPB4MSLbXI_4U7sXmGTzsS0qunsMZ4kNJ9-wLJX60KB5zj4Y2s01gU6KLsH7F2ppZdoy3P49sv11Eapic7oXv14IdTX8cs1_WU8CdTSjphXwCbN6wfWI2CPZyhc2_UaW-gJOD6c_JYTrUU0g92mXL1KAxEaz0ruaqFmXMnBW1ccZzHouoAhWT1F5SwSrjVK1t6XDWhfJccx-yWr6EraZt4mtg-FsYtc144C5XseRO2zqaPC9QIPI8uATEelYrP5CNU82L86oLektT9UhUiETVIVGpBD6O11z0VBt3jt5Zg1UNy25R3QhJAu_HblwwFAWxTWyv-jGSigiYBF712I6Pk0QuJGSRQLGB-jiAyLg3e5r5aUfKrY0ShcwS-LSWj5vX-v9XbN_9FW_gUUay2rmxd2BreXkV36IRtHTvOkn_CzgZA_c
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VVkhcUHmHlspI3CDCThzHOa62W5WVChJLUW-RX1EXlQR1txL775nJCy2lSFzjceLkG2fGHs83AG9sqKy3DhFwxscysyK2UqsYbYEKAnsVOeU7n31Up-dyfpFd7EAy5MK0h_ZbSsv2Nz2cDnu_QkNDyWCiiIkyjMfyHuwRVTvq9t5kMl_Mx50Vil1JUfQZMjzVf-m8bYVuuZa3T0j-ESZtrc_JPjzs3UY26Qb6CHZC_Rjud4UkN0_gG6JCqfbsA6V7NKgUS4fuNTO1ZzMiiTBuw5qKGbbA218FdtysAl2YXk78p5-Cnc0-L9hX4yjMzqaU6kI7AWxZs2PiM_DmeoOXv6MhfQrnJ7Mv09O4r6IQO_TG1rFGF8Kb1NmKy0oUIbFGVNpqx3nIg_RUQlK5lMpUaSsrZQqLPp-QjivufFKlz2C3burwAhguBoMyCffcZjIU3CpTBZ1lOapBlnkbgRi-aul6inGqdHFVtqHuVJcdEiUiUbZIlDKCt2OfHx3Bxj-lDwewyn6yrUocLi58CpSI4PXYjNOEYh-mDs1NJ5NS6QAdwfMO2_FxKVEKiTSPIN9CfRQgCu7tlnp52VJxKy1FniYRvBv04_ew7n6Ll_8nfgAPEtLddjP7EHbX1zfhFbpCa3vU6_4vH_ADMg
  priority: 102
  providerName: Springer Nature
Title Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels
URI https://link.springer.com/article/10.1038/s41598-019-52730-4
https://www.ncbi.nlm.nih.gov/pubmed/31705137
https://www.proquest.com/docview/2313069273
https://www.proquest.com/docview/2313384818
https://pubmed.ncbi.nlm.nih.gov/PMC6841732
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED_tQ6C9ID5HYFRG4g0CceIkzgNCJes0KnWglaK-RbbjaEVdMtpOWv977vJRGBs88BTJPseO76w727nfD-CVtoXOtUENGJW7ItTc1UJGLvqCyHJslcSU7zw6iY4nYjgNp1vQ0R21E7i8dWtHfFKTxfzt1Y_1B1zw75uUcfluiU6IEsV44hKcmOeKbdhFzxQTo8GoDfcbrG8_ETxpc2dub7oHdwOCmOHEjP67q7oRf978jfKPu9TaRR3dh3ttbMn6jTE8gC1bPoQ7Ddvk-hF8R9VRPj77RDkhFVrOzGAMzlSZswEhSSizZlXBFBvj6-eWHVZLSwXpWT__fMXZaHA6Zt-Uobt4llI-DB0XsFnJDgn0IFeLNRafo7d9DJOjwdf02G2pFlyDIdvKlRhn5CowuvBEwRPra8ULqaXxPBtbkRPPZGQC4rKSWhSRSjQGhlwYL_JM7hfBE9gpq9I-BYY7Rhsp38s9HQqbeDpShZVhGKOthGGuHeDdrGamxSEnOox5Vt-HBzJrlJKhUrJaKZlw4PWmzUWDwvFP6YNOWVlnUBkOF3dHCUo48HJTjWuJLkhUaavLRiYgfgHpwH6j2013nVE4EF_T-kaAcLqv15SzsxqvO5Joi4HvwJvOPn4N6-9f8ey_O3oOez5ZdH34fQA7q8WlfYGh00r3YDuexj3Y7feH4yE-Pw5OvpxiaRqlvfo4olevmJ_pAhpe
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VIgQXxBtDC4sEJ7C6a69fB1RVSaqENkWiLcrN7MtqULFLkwryp_iNzPiRKlT01qv35d35dmd2ZmcG4K12hbbaIAWMsr6MtPC1TGMfeUHsBLbKEvJ3Hh_Ew2P5aRJN1uBP5wtDzyq7M7E-qG1lSEe-hXIISrcZctvts58-ZY0i62qXQqOBxZ5b_MIr2-zjqI_0fRcEu4Oj3tBvswr4BqWTuZ8iS7UqNLrgshCZC7QSRapTw7lLnLSUUjE2IaVtSrUsYpVpHFtIw2NubFCE2O8tuI2Ml9NlL5kkS50OWc2kyFrfHB6mWzPkj-TDJjKfIp1xX67yvytC7dW3mf8YaGu-t_sA7rcCK9tpEPYQ1lz5CO40KSwXj-E74oGc_NmIHE0qhOPUoGDPVGnZgMJTKLNgVcEUO8TuTx3rVzNHH3onO_bzb8HGgy-H7KsyZOBnPXKyIR0Em5asT5EUrDpf4OcfyMKfwPGNrPRTWC-r0j0HhtdQF6uAW64j6TKuY1W4NIoSBGAUWe2B6FY1N21wc8qxcZrXRvYwzRtK5EiJvKZELj14v2xz1oT2uLb2RkesvN3ms_wSlB68WRbjBiWriypdddHUCSlpQerBs4a2y-FCCmYkwsSDZIXqywoU_Hu1pJye1EHA41SKJAw8-NDh4_K3_j-LF9fP4jXcHR6N9_P90cHeS7gXEG5rFfoGrM_PL9wmCmBz_apGPYNvN73N_gK5XUBq
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zb9QwEB6VrUC8IG4CBYwETxBtnDjXA0JlD3UpXaqWVn0LvqIuKknpbgX71_h1zOSqloq-9TU-Yns-e8YznhmA18rmyiiNFNDSuCJU3FUiiVzkBZHl2CqNyd95ZxptHYhPR-HRGvxpfWHoWWV7JlYHtSk16cj7KIegdJsit-3nzbOI3eH4w-lPlzJIkaW1TadRQ2TbLn_h9W3-fjJEWr_x_fHo62DLbTIMuBollYWbIHs1MtAq90TOU-sryfNEJdrzbGyFofSKkQ4ohVOiRB7JVOE4uNBe5Gnj5wH2ewPWY7oV9WD942i6u9dpeMiGJnjaeOp4QdKfI7ckjzaeuhT3zHPFKje8JOJefqn5j7m24oLju3CnEV_ZZo23e7Bmi_tws05ouXwA3xEd5PLPJuR2UiI4ZxrFfCYLw0YUrELqJStzJtk-dn9i2bCcW_owON40X35ztjPa22eHUpO5nw3I5YY0EmxWsCHFVTDybImffyBDfwgH17LWj6BXlIV9AgwvpTaSvmc8FQqbeiqSuU3CMEY4hqFRDvB2VTPdhDqnjBsnWWVyD5KspkSGlMgqSmTCgbddm9M60MeVtTdaYmXNpp9nFxB14FVXjNuVbDCysOV5XSegFAaJA49r2na_Cyi0EQ9iB-IVqncVKBT4akkxO65CgkeJ4HHgO_CuxcfFsP4_i6dXz-Il3MItln2eTLefwW2fYFvp0zegtzg7t89RGluoFw3sGXy77p32F0ZmRgU
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Humoral+Immunogenicity+and+Efficacy+of+a+Single+Dose+of+ChAdOx1+MERS+Vaccine+Candidate+in+Dromedary+Camels&rft.jtitle=Scientific+reports&rft.au=Alharbi%2C+Naif+Khalaf&rft.au=Qasim%2C+Ibrahim&rft.au=Almasoud%2C+Abdulrahman&rft.au=Aljami%2C+Haya+A.&rft.date=2019-11-08&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=9&rft_id=info:doi/10.1038%2Fs41598-019-52730-4&rft_id=info%3Apmid%2F31705137&rft.externalDocID=PMC6841732
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon