Large scale validation of an early-age eye-tracking biomarker of an autism spectrum disorder subtype

Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances in precision medicine. As such, the goal of the present study was to leverage both simple an...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 12; no. 1; p. 4253
Main Authors Wen, Teresa H., Cheng, Amanda, Andreason, Charlene, Zahiri, Javad, Xiao, Yaqiong, Xu, Ronghui, Bao, Bokan, Courchesne, Eric, Barnes, Cynthia Carter, Arias, Steven J., Pierce, Karen
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 11.03.2022
Nature Publishing Group
Nature Portfolio
Subjects
692/308/3187
692/53/2421
692/617/375/366/1373
Autism
Biomarkers
Clinical trials
Eye
Humanities and Social Sciences
multidisciplinary
Precision medicine
Primary care
Science
Science (multidisciplinary)
Toddlers
Visual perception
Online AccessGet full text

Cover

Abstract Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances in precision medicine. As such, the goal of the present study was to leverage both simple and computationally-advanced approaches to validate an eye-tracking measure of social attention preference, the GeoPref Test, among 1,863 ASD, delayed, or typical toddlers (12–48 months) referred from the community or general population via a primary care universal screening program. Toddlers participated in diagnostic and psychometric evaluations and the GeoPref Test: a 1-min movie containing side-by-side dynamic social and geometric images. Following testing, diagnosis was denoted as ASD, ASD features, LD, GDD, Other, typical sibling of ASD proband, or typical. Relative to other diagnostic groups, ASD toddlers exhibited the highest levels of visual attention towards geometric images and those with especially high fixation levels exhibited poor clinical profiles. Using the 69% fixation threshold, the GeoPref Test had 98% specificity, 17% sensitivity, 81% PPV, and 65% NPV. Sensitivity increased to 33% when saccades were included, with comparable validity across sex, ethnicity, or race. The GeoPref Test was also highly reliable up to 24 months following the initial test. Finally, fixation levels among twins concordant for ASD were significantly correlated, indicating that GeoPref Test performance may be genetically driven. As the GeoPref Test yields few false positives (~ 2%) and is equally valid across demographic categories, the current findings highlight the ability of the GeoPref Test to rapidly and accurately detect autism before the 2nd birthday in a subset of children and serve as a biomarker for a unique ASD subtype in clinical trials.
AbstractList Abstract Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances in precision medicine. As such, the goal of the present study was to leverage both simple and computationally-advanced approaches to validate an eye-tracking measure of social attention preference, the GeoPref Test, among 1,863 ASD, delayed, or typical toddlers (12–48 months) referred from the community or general population via a primary care universal screening program. Toddlers participated in diagnostic and psychometric evaluations and the GeoPref Test: a 1-min movie containing side-by-side dynamic social and geometric images. Following testing, diagnosis was denoted as ASD, ASD features, LD, GDD, Other, typical sibling of ASD proband, or typical. Relative to other diagnostic groups, ASD toddlers exhibited the highest levels of visual attention towards geometric images and those with especially high fixation levels exhibited poor clinical profiles. Using the 69% fixation threshold, the GeoPref Test had 98% specificity, 17% sensitivity, 81% PPV, and 65% NPV. Sensitivity increased to 33% when saccades were included, with comparable validity across sex, ethnicity, or race. The GeoPref Test was also highly reliable up to 24 months following the initial test. Finally, fixation levels among twins concordant for ASD were significantly correlated, indicating that GeoPref Test performance may be genetically driven. As the GeoPref Test yields few false positives (~ 2%) and is equally valid across demographic categories, the current findings highlight the ability of the GeoPref Test to rapidly and accurately detect autism before the 2nd birthday in a subset of children and serve as a biomarker for a unique ASD subtype in clinical trials.
Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances in precision medicine. As such, the goal of the present study was to leverage both simple and computationally-advanced approaches to validate an eye-tracking measure of social attention preference, the GeoPref Test, among 1,863 ASD, delayed, or typical toddlers (12–48 months) referred from the community or general population via a primary care universal screening program. Toddlers participated in diagnostic and psychometric evaluations and the GeoPref Test: a 1-min movie containing side-by-side dynamic social and geometric images. Following testing, diagnosis was denoted as ASD, ASD features, LD, GDD, Other, typical sibling of ASD proband, or typical. Relative to other diagnostic groups, ASD toddlers exhibited the highest levels of visual attention towards geometric images and those with especially high fixation levels exhibited poor clinical profiles. Using the 69% fixation threshold, the GeoPref Test had 98% specificity, 17% sensitivity, 81% PPV, and 65% NPV. Sensitivity increased to 33% when saccades were included, with comparable validity across sex, ethnicity, or race. The GeoPref Test was also highly reliable up to 24 months following the initial test. Finally, fixation levels among twins concordant for ASD were significantly correlated, indicating that GeoPref Test performance may be genetically driven. As the GeoPref Test yields few false positives (~ 2%) and is equally valid across demographic categories, the current findings highlight the ability of the GeoPref Test to rapidly and accurately detect autism before the 2nd birthday in a subset of children and serve as a biomarker for a unique ASD subtype in clinical trials.
Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances in precision medicine. As such, the goal of the present study was to leverage both simple and computationally-advanced approaches to validate an eye-tracking measure of social attention preference, the GeoPref Test, among 1,863 ASD, delayed, or typical toddlers (12–48 months) referred from the community or general population via a primary care universal screening program. Toddlers participated in diagnostic and psychometric evaluations and the GeoPref Test: a 1-min movie containing side-by-side dynamic social and geometric images. Following testing, diagnosis was denoted as ASD, ASD features, LD, GDD, Other, typical sibling of ASD proband, or typical. Relative to other diagnostic groups, ASD toddlers exhibited the highest levels of visual attention towards geometric images and those with especially high fixation levels exhibited poor clinical profiles. Using the 69% fixation threshold, the GeoPref Test had 98% specificity, 17% sensitivity, 81% PPV, and 65% NPV. Sensitivity increased to 33% when saccades were included, with comparable validity across sex, ethnicity, or race. The GeoPref Test was also highly reliable up to 24 months following the initial test. Finally, fixation levels among twins concordant for ASD were significantly correlated, indicating that GeoPref Test performance may be genetically driven. As the GeoPref Test yields few false positives (~ 2%) and is equally valid across demographic categories, the current findings highlight the ability of the GeoPref Test to rapidly and accurately detect autism before the 2nd birthday in a subset of children and serve as a biomarker for a unique ASD subtype in clinical trials.
Abstract Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances in precision medicine. As such, the goal of the present study was to leverage both simple and computationally-advanced approaches to validate an eye-tracking measure of social attention preference, the GeoPref Test, among 1,863 ASD, delayed, or typical toddlers (12–48 months) referred from the community or general population via a primary care universal screening program. Toddlers participated in diagnostic and psychometric evaluations and the GeoPref Test: a 1-min movie containing side-by-side dynamic social and geometric images. Following testing, diagnosis was denoted as ASD, ASD features, LD, GDD, Other, typical sibling of ASD proband, or typical. Relative to other diagnostic groups, ASD toddlers exhibited the highest levels of visual attention towards geometric images and those with especially high fixation levels exhibited poor clinical profiles. Using the 69% fixation threshold, the GeoPref Test had 98% specificity, 17% sensitivity, 81% PPV, and 65% NPV. Sensitivity increased to 33% when saccades were included, with comparable validity across sex, ethnicity, or race. The GeoPref Test was also highly reliable up to 24 months following the initial test. Finally, fixation levels among twins concordant for ASD were significantly correlated, indicating that GeoPref Test performance may be genetically driven. As the GeoPref Test yields few false positives (~ 2%) and is equally valid across demographic categories, the current findings highlight the ability of the GeoPref Test to rapidly and accurately detect autism before the 2nd birthday in a subset of children and serve as a biomarker for a unique ASD subtype in clinical trials.
ArticleNumber 4253
Author Barnes, Cynthia Carter
Andreason, Charlene
Bao, Bokan
Zahiri, Javad
Courchesne, Eric
Cheng, Amanda
Arias, Steven J.
Xu, Ronghui
Xiao, Yaqiong
Pierce, Karen
Wen, Teresa H.
Author_xml – sequence: 1
  givenname: Teresa H.
  surname: Wen
  fullname: Wen, Teresa H.
  email: thwen@health.ucsd.edu
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 2
  givenname: Amanda
  surname: Cheng
  fullname: Cheng, Amanda
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 3
  givenname: Charlene
  surname: Andreason
  fullname: Andreason, Charlene
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 4
  givenname: Javad
  surname: Zahiri
  fullname: Zahiri, Javad
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 5
  givenname: Yaqiong
  surname: Xiao
  fullname: Xiao, Yaqiong
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 6
  givenname: Ronghui
  surname: Xu
  fullname: Xu, Ronghui
  organization: Herbert Wertheim School of Public Health and Department of Mathematics, University of California, San Diego
– sequence: 7
  givenname: Bokan
  surname: Bao
  fullname: Bao, Bokan
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego, Department of Bioinformatics and Systems Biology, University of California, San Diego
– sequence: 8
  givenname: Eric
  surname: Courchesne
  fullname: Courchesne, Eric
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 9
  givenname: Cynthia Carter
  surname: Barnes
  fullname: Barnes, Cynthia Carter
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 10
  givenname: Steven J.
  surname: Arias
  fullname: Arias, Steven J.
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
– sequence: 11
  givenname: Karen
  surname: Pierce
  fullname: Pierce, Karen
  email: kpierce@health.ucsd.edu
  organization: Autism Center of Excellence, Department of Neurosciences, University of California, San Diego
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35277549$$D View this record in MEDLINE/PubMed
BookMark eNp9kktv1DAUhSNUREvpH2CBIrFhE7CvHT82SKjiUWkkNrC2bvwY3GbiwU4qzb-vOzOUlgXe2PL57vG91nnZnExp8k3zmpL3lDD1oXDaa9URgI4oSqATz5ozILzvgAGcPDqfNhelXJO6etCc6hfNKetByp7rs8atMK99WyyOvr3FMTqcY5raFFqcWo953HVYAb_z3ZzR3sRp3Q4xbTDf-HzEcJlj2bRl6-2cl03rYknZVbksw7zb-lfN84Bj8RfH_bz5-eXzj8tv3er716vLT6vO9pzMnSJag4QhWC6I5kQJpdAKTnopqUTpBCDQ4AYMbCAcnQg0VICCFBoJsvPm6uDrEl6bbY61y51JGM3-IuW1wTxHO3rjUNleaQKeO64ER-FVkIwxVIE4F6rXx4PXdhk23lk_1fHHJ6ZPlSn-Mut0a5SmEhitBu-OBjn9XnyZzSYW68cRJ5-WYkAwJQG41BV9-w96nZY81a_aU1RK0PcUHCibUynZh4dmKDH3mTCHTJiaCbPPhBG16M3jMR5K_iSgAuwAlCpNa5__vv0f2zvqScQR
CitedBy_id crossref_primary_10_1016_j_rasd_2023_102228
crossref_primary_10_1109_ACCESS_2024_3351168
crossref_primary_10_1016_j_rasd_2023_102258
crossref_primary_10_1001_jamanetworkopen_2022_55125
crossref_primary_10_1016_j_cub_2024_03_020
crossref_primary_10_3389_fpsyt_2023_1294254
crossref_primary_10_3389_fped_2024_1405110
crossref_primary_10_1055_a_2022_0301
crossref_primary_10_1016_j_displa_2024_102788
crossref_primary_10_1038_s41591_023_02557_4
crossref_primary_10_1186_s13229_023_00543_8
crossref_primary_10_1001_jamanetworkopen_2024_11190
crossref_primary_10_1007_s40474_022_00252_6
crossref_primary_10_1038_s41591_023_02574_3
crossref_primary_10_1007_s10803_024_06360_z
crossref_primary_10_1146_annurev_biodatasci_020722_125454
crossref_primary_10_1002_aur_3026
crossref_primary_10_1016_j_cpr_2022_102230
crossref_primary_10_1186_s13229_024_00602_8
crossref_primary_10_1093_cercor_bhad434
Cites_doi 10.1016/j.brainres.2010.11.074
10.1016/j.jpeds.2011.02.036
10.1002/dev.20503
10.1017/S003329171900031X
10.1007/s10803-021-04878-0
10.1161/CIRCULATIONAHA.116.023005
10.1002/aur.1479
10.1111/jcpp.12448
10.1037/h0030432
10.1111/j.1532-7078.2011.00086.x
10.1038/s41380-018-0056-y
10.1186/s13229-020-00321-w
10.2105/AJPH.2007.118505
10.1007/s10803-013-1910-z
10.1371/journal.pone.0188826
10.1186/s13229-018-0202-z
10.1038/srep25776
10.1001/archgenpsychiatry.2010.113
10.1080/00221325.1979.10533411
10.1177/0142723719885270
10.1016/j.neuron.2015.03.023
10.1038/nature22999
10.1080/10485252.2017.1404598
10.1007/BF01837899
10.1007/s10803-021-05019-3
10.1016/j.tins.2020.03.005
10.3389/fnint.2020.00016
10.1056/nejm198805263182102
10.3109/13668250.2019.1698287
10.1007/s10803-020-04615-z
10.1111/j.1469-7610.2012.02538.x
10.1016/j.biopsych.2015.03.032
10.1016/j.biopsych.2012.11.022
10.1371/journal.pone.0252795
10.2307/1126468
10.1016/j.ridd.2017.06.011
10.1038/s41588-019-0344-8
10.1111/infa.12402
10.1016/j.dcn.2017.08.006
10.1016/j.jaac.2018.06.023
10.1186/1866-1955-5-7
10.1038/nature12715
10.1038/nature07868
10.1016/j.conctc.2019.100396
10.1038/nrneurol.2013.278
10.1038/s41598-021-87888-3
10.1007/s00787-020-01516-5
10.1177/1362361316681481
10.1002/aur.156
10.18637/jss.v046.i11
10.1007/s10803-020-04493-5
10.1007/s10803-016-2975-2
10.1001/archpsyc.59.9.809
10.1002/aur.2036
10.1001/jamanetworkopen.2021.0771
10.1177/1362361319878578
10.3389/fnins.2016.00586
10.1038/s41398-020-0830-x
10.1038/nm.4071
10.1186/s13229-020-00388-5
10.1016/j.ridd.2015.10.011
10.1371/journal.pone.0122280
10.1542/peds.56.4.544
10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z
10.1002/aur.2498
10.15585/mmwr.ss6706a1
10.1016/j.dcn.2017.08.005
10.1001/archpsyc.65.8.946
10.1176/appi.ajp.2020.20010015
10.1186/1471-2105-9-559
10.1352/1934-9556-56.5.321
10.1038/tp.2016.75
10.1016/j.rasd.2020.101614
10.1200/po.17.00135
10.1002/aur.4
10.1001/jama.2009.1064
10.1002/aur.2093
10.1016/j.cpr.2021.102033
10.1080/00221325.1970.10533940
10.1037//0012-1649.18.5.704
10.1109/TAFFC.2018.2890610
10.1002/aur.2556
10.1097/00001648-200207000-00009
10.1001/jamapediatrics.2021.0530
10.1186/1471-2105-12-77
10.1073/pnas.1506352112
10.1002/hbm.24400
10.7554/eLife.47427
10.1111/j.1469-7610.2004.00318.x
10.1007/s10803-019-04315-3
10.1111/j.2041-210X.2011.00125.x
10.1017/s0954579412001071
10.18637/jss.v082.i04
10.15585/mmwr.ss6904a1
10.1002/aur.2021
10.1177/1362361315617879
10.1186/s11689-019-9262-4
10.1016/j.rasd.2011.11.005
10.1016/j.rasd.2021.101745
10.1093/acrefore/9780190632366.013.181
10.1101/2021.10.08.463640
10.1016/j.jpeds.2021.04.041
ContentType Journal Article
Copyright The Author(s) 2022
2022. The Author(s).
The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2022
– notice: 2022. The Author(s).
– notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
NPM
AAYXX
CITATION
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.1038/s41598-022-08102-6
DatabaseName Springer_OA刊
PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest_Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
ProQuest Science Journals
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

Publicly Available Content Database
CrossRef
PubMed

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer_OA刊
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 4253
ExternalDocumentID oai_doaj_org_article_da8c58902e4d4864a6e8f7333a8f0ddf
10_1038_s41598_022_08102_6
35277549
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: National Institute of Mental Health
  grantid: P50-MH081755; R01MH118879
  funderid: http://dx.doi.org/10.13039/100000025
– fundername: NIMH NIH HHS
  grantid: R01MH118879
– fundername: NIMH NIH HHS
  grantid: R01 MH080134
– fundername: NIMH NIH HHS
  grantid: P50-MH081755
– fundername: ;
  grantid: P50-MH081755; R01MH118879
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ADBBV
ADRAZ
AENEX
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNT
RNTTT
RPM
SNYQT
UKHRP
AFPKN
NPM
AAYXX
CITATION
7XB
8FK
K9.
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c540t-8099272bfc4609408688ac64057717a7d62a21fdbaf3b04ad6f1fac612769a0a3
IEDL.DBID RPM
ISSN 2045-2322
IngestDate Fri Oct 04 13:10:38 EDT 2024
Tue Sep 17 21:09:48 EDT 2024
Tue Aug 27 04:48:10 EDT 2024
Thu Oct 10 21:57:43 EDT 2024
Fri Aug 23 02:47:15 EDT 2024
Sat Sep 28 08:19:33 EDT 2024
Fri Oct 11 20:56:04 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2022. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-8099272bfc4609408688ac64057717a7d62a21fdbaf3b04ad6f1fac612769a0a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917231/
PMID 35277549
PQID 2638177299
PQPubID 2041939
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_da8c58902e4d4864a6e8f7333a8f0ddf
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8917231
proquest_miscellaneous_2638722479
proquest_journals_2638177299
crossref_primary_10_1038_s41598_022_08102_6
pubmed_primary_35277549
springer_journals_10_1038_s41598_022_08102_6
PublicationCentury 2000
PublicationDate 2022-03-11
PublicationDateYYYYMMDD 2022-03-11
PublicationDate_xml – month: 03
  year: 2022
  text: 2022-03-11
  day: 11
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Elison, Sasson, Turner-Brown, Dichter, Bodfish (CR26) 2012; 6
Chang (CR34) 2021
Unruh (CR15) 2016; 10
Kanner (CR10) 1943; 2
CR32
Jensen (CR39) 2021; 51
Sasson, Touchstone (CR13) 2014; 44
Chawner (CR84) 2021; 178
Mattsson (CR52) 2009; 302
Lord (CR62) 1995
De La Torre-Ubieta, Won, Stein, Geschwind (CR6) 2016; 22
Shaffer (CR42) 2017; 47
Lerer (CR115) 2010; 3
Theppeang (CR49) 2008; 98
Manyakov (CR92) 2018; 11
Lew (CR50) 2017; 135
Baio (CR4) 2018; 67
Jones, Klin (CR29) 2013; 504
Le (CR48) 2020
Weizmann, Cohen, Pratt (CR101) 1971; 4
Wang, Chen, Liu, Polk, Feng (CR41) 2020; 78
Goren, Sarty, Wu (CR98) 1975; 56
Dababnah, Shaia, Campion, Nichols (CR114) 2018; 56
Grove (CR80) 2019; 51
Courchesne, Gazestani, Lewis (CR2) 2020; 43
Pierce (CR16) 2016; 79
Chawarska, Macari, Shic (CR28) 2013; 74
Hunt (CR100) 1970; 117
Hultman, Sparén, Cnattingius (CR78) 2002; 13
Robin, Hainard, Tiberti, Lisacek, Sanchez, Mülle (CR68) 2011; 12
Mendel (CR106) 1965; 36
Imafuku, Kawai, Niwa, Shinya, Myowa (CR45) 2021; 26
Courchesne, Yeung-Courchesne, Hesselink, Jernigan (CR77) 1988; 318
Mcpartland, Dawson, Webb, Panagiotides, Carver (CR9) 2004; 45
Hong (CR19) 2019; 11
Chevallier (CR14) 2015; 8
Baio (CR81) 2014; 63
Zhou, Ma, Zhan (CR90) 2020; 40
Fujioka (CR37) 2020; 11
Gunderson (CR93) 2021; 14
Bacon (CR20) 2020; 24
Wolak, Fairbairn, Paulsen (CR70) 2012; 3
Langfelder (CR72) 2008
Chen (CR87) 2019; 40
McPartland (CR8) 2020; 14
Courchesne (CR5) 2019; 24
Frank, Vul, Saxe (CR99) 2012; 17
Pierce, Conant, Hazin, Stoner, Desmond (CR25) 2011; 68
Bovery, Dawson, Hashemi, Sapiro (CR18) 2018
Pierce (CR33) 2011; 159
Jung (CR75) 2018; 30
CR69
CR66
CR65
Shi (CR44) 2015; 10
CR64
Perez-Jaume, Skaltsa, Pallarès, Carrasco (CR67) 2017; 82
Rutherford (CR108) 2016; 20
Jones, Carr, Klin (CR22) 2008; 65
Chawarska, MacAri, Shic (CR27) 2012; 53
Dellapiazza (CR95) 2021; 30
Frazier (CR7) 2021
Billeci (CR51) 2016; 6
Lombardo (CR85) 2015; 86
CR79
Constantino (CR59) 2017; 547
Key, Jones, Dykens (CR55) 2013; 5
CR74
CR73
CR111
Frazier (CR91) 2020; 45
Lombardo (CR31) 2019; 8
Bonnet-Brilhault (CR1) 2018; 11
Courchesne, Lincoln, Kilman, Galambos (CR103) 1985; 15
Baranek (CR94) 2013; 25
Damiano-Goodwin (CR97) 2018; 29
Bradshaw (CR43) 2019; 12
Fombonne, Zuckerman (CR110) 2021
Park, Harari, Dron, Mills, Thorlund (CR76) 2019; 15
Klin, Jones, Schultz, Volkmar, Cohen (CR11) 2002; 59
CR89
Debladis (CR57) 2019; 3
Del Valle Rubido (CR46) 2020; 50
Shic, Bradshaw, Klin, Scassellati, Chawarska (CR24) 2011; 1380
Cui (CR54) 2016; 6
Wetherby, Prizant (CR60) 2002
Frazier (CR82) 2018; 57
Agelink Van Rentergem, Deserno, Geurts (CR88) 2021; 87
Langfelder (CR71) 2012; 46
Klein, Jennings (CR104) 1979; 135
Wang (CR58) 2020; 50
Jamison, Bishop, Huerta, Halladay (CR113) 2017; 21
Wood-Downie (CR109) 2021; 51
Klin, Lin, Gorrindo, Ramsay, Jones (CR23) 2009; 459
Vargas-Cuentas (CR38) 2017; 12
Jeste, Geschwind (CR83) 2014; 10
Rose, Gottfried, Melloy-Carminar, Bridger (CR102) 1982; 18
Vacas, Antolí, Sánchez-Raya, Pérez-Dueñas, Cuadrado (CR35) 2021; 16
Sasson, Turner-Brown, Holtzclaw, Lam, Bodfish (CR12) 2008; 1
Maenner (CR3) 2020; 69
Mullen (CR61) 1995
Baranek (CR96) 2018; 29
Chita-Tegmark (CR30) 2016; 48
Buffle, Cavadini, Posada, Gentaz (CR36) 2021
Moore (CR17) 2018; 9
Kim, Macari, Koller, Chawarska (CR86) 2016; 57
Morgan, Hayne (CR107) 2011; 53
Kaliukhovich (CR21) 2020; 11
Krol, Monakhov, Lai, Ebstein, Grossmann (CR56) 2015; 112
Brueffer (CR53) 2018
Huttenlocher, Dabholkar (CR105) 1997; 387
Yuan, Li, Lu (CR112) 2021; 4
Sparrow, Balla, Cicchetti (CR63) 1984
Harrison, Slane (CR40) 2020; 50
Hong (CR47) 2017; 68
A Moore (8102_CR17) 2018; 9
C Brueffer (8102_CR53) 2018
S Sparrow (8102_CR63) 1984
CR Damiano-Goodwin (8102_CR97) 2018; 29
J Le (8102_CR48) 2020
K Pierce (8102_CR16) 2016; 79
XTN Robin (8102_CR68) 2011; 12
J Bradshaw (8102_CR43) 2019; 12
PHS Langfelder (8102_CR72) 2008
N Mattsson (8102_CR52) 2009; 302
JN Constantino (8102_CR59) 2017; 547
J Lew (8102_CR50) 2017; 135
F Dellapiazza (8102_CR95) 2021; 30
MC Frank (8102_CR99) 2012; 17
EC Bacon (8102_CR20) 2020; 24
CM Hultman (8102_CR78) 2002; 13
SJRA Chawner (8102_CR84) 2021; 178
E Fombonne (8102_CR110) 2021
S Perez-Jaume (8102_CR67) 2017; 82
J Mcpartland (8102_CR9) 2004; 45
CC Goren (8102_CR98) 1975; 56
K Jensen (8102_CR39) 2021; 51
C Chevallier (8102_CR14) 2015; 8
S Dababnah (8102_CR114) 2018; 56
F Shic (8102_CR24) 2011; 1380
J Vacas (8102_CR35) 2021; 16
K Pierce (8102_CR33) 2011; 159
NV Manyakov (8102_CR92) 2018; 11
K Morgan (8102_CR107) 2011; 53
E Courchesne (8102_CR103) 1985; 15
ME Wolak (8102_CR70) 2012; 3
Y Cui (8102_CR54) 2016; 6
NJ Sasson (8102_CR13) 2014; 44
E Courchesne (8102_CR5) 2019; 24
JJ Park (8102_CR76) 2019; 15
L De La Torre-Ubieta (8102_CR6) 2016; 22
L Kanner (8102_CR10) 1943; 2
M Rutherford (8102_CR108) 2016; 20
SS Jeste (8102_CR83) 2014; 10
K Chawarska (8102_CR28) 2013; 74
EM Mullen (8102_CR61) 1995
H Chen (8102_CR87) 2019; 40
M Del Valle Rubido (8102_CR46) 2020; 50
C Lord (8102_CR62) 1995
8102_CR89
G Mendel (8102_CR106) 1965; 36
AM Wetherby (8102_CR60) 2002
8102_CR73
J Baio (8102_CR4) 2018; 67
K Pierce (8102_CR25) 2011; 68
VM Lombardo (8102_CR85) 2015; 86
F Bonnet-Brilhault (8102_CR1) 2018; 11
TW Frazier (8102_CR7) 2021
JM Hunt (8102_CR100) 1970; 117
DA Kaliukhovich (8102_CR21) 2020; 11
Y Jung (8102_CR75) 2018; 30
SH Kim (8102_CR86) 2016; 57
T Fujioka (8102_CR37) 2020; 11
NI Vargas-Cuentas (8102_CR38) 2017; 12
J Debladis (8102_CR57) 2019; 3
L Wang (8102_CR58) 2020; 50
A Klin (8102_CR11) 2002; 59
8102_CR74
8102_CR79
TW Frazier (8102_CR91) 2020; 45
P Huttenlocher (8102_CR105) 1997; 387
AJ Harrison (8102_CR40) 2020; 50
E Courchesne (8102_CR77) 1988; 318
MP Hong (8102_CR19) 2019; 11
RP Klein (8102_CR104) 1979; 135
TW Frazier (8102_CR82) 2018; 57
J Grove (8102_CR80) 2019; 51
K Theppeang (8102_CR49) 2008; 98
W Jones (8102_CR29) 2013; 504
8102_CR64
J Gunderson (8102_CR93) 2021; 14
SA Rose (8102_CR102) 1982; 18
A Klin (8102_CR23) 2009; 459
8102_CR66
8102_CR65
MP Hong (8102_CR47) 2017; 68
R Jamison (8102_CR113) 2017; 21
8102_CR69
P Buffle (8102_CR36) 2021
JA Agelink Van Rentergem (8102_CR88) 2021; 87
MDMJ Bovery (8102_CR18) 2018
L Billeci (8102_CR51) 2016; 6
RC Shaffer (8102_CR42) 2017; 47
M Imafuku (8102_CR45) 2021; 26
AP Key (8102_CR55) 2013; 5
MV Lombardo (8102_CR31) 2019; 8
P Zhou (8102_CR90) 2020; 40
PHS Langfelder (8102_CR71) 2012; 46
H Wood-Downie (8102_CR109) 2021; 51
E Lerer (8102_CR115) 2010; 3
KE Unruh (8102_CR15) 2016; 10
F Weizmann (8102_CR101) 1971; 4
J Yuan (8102_CR112) 2021; 4
Z Chang (8102_CR34) 2021
L Shi (8102_CR44) 2015; 10
K Chawarska (8102_CR27) 2012; 53
J Baio (8102_CR81) 2014; 63
GT Baranek (8102_CR96) 2018; 29
KM Krol (8102_CR56) 2015; 112
JC McPartland (8102_CR8) 2020; 14
E Courchesne (8102_CR2) 2020; 43
W Jones (8102_CR22) 2008; 65
8102_CR111
M Chita-Tegmark (8102_CR30) 2016; 48
GT Baranek (8102_CR94) 2013; 25
NJ Sasson (8102_CR12) 2008; 1
8102_CR32
X Wang (8102_CR41) 2020; 78
JT Elison (8102_CR26) 2012; 6
MJ Maenner (8102_CR3) 2020; 69
References_xml – volume: 1380
  start-page: 246
  year: 2011
  end-page: 254
  ident: CR24
  article-title: Limited activity monitoring in toddlers with autism spectrum disorder
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2010.11.074
  contributor:
    fullname: Chawarska
– ident: CR74
– volume: 159
  start-page: 458
  year: 2011
  end-page: 465.e456
  ident: CR33
  article-title: Detecting, studying, and treating autism early: The one-year well-baby check-up approach
  publication-title: J. Pediatr.
  doi: 10.1016/j.jpeds.2011.02.036
  contributor:
    fullname: Pierce
– volume: 2
  start-page: 217
  year: 1943
  end-page: 250
  ident: CR10
  article-title: Autistic disturbances of affective contact
  publication-title: Nervous Child
  contributor:
    fullname: Kanner
– volume: 53
  start-page: 157
  year: 2011
  end-page: 165
  ident: CR107
  article-title: Age-related changes in visual recognition memory during infancy and early childhood
  publication-title: Dev. Psychobiol.
  doi: 10.1002/dev.20503
  contributor:
    fullname: Hayne
– volume: 50
  start-page: 475
  year: 2020
  end-page: 483
  ident: CR58
  article-title: Heritability of reflexive social attention triggered by eye gaze and walking direction: Common and unique genetic underpinnings
  publication-title: Psychol. Med.
  doi: 10.1017/S003329171900031X
  contributor:
    fullname: Wang
– volume: 51
  start-page: 994
  year: 2021
  end-page: 1006
  ident: CR39
  article-title: Autism detection in children by combined use of gaze preference and the M-CHAT-R in a resource-scarce setting
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-021-04878-0
  contributor:
    fullname: Jensen
– volume: 135
  start-page: 544
  year: 2017
  end-page: 555
  ident: CR50
  article-title: Sex-based differences in cardiometabolic biomarkers
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.023005
  contributor:
    fullname: Lew
– volume: 8
  start-page: 620
  year: 2015
  end-page: 628
  ident: CR14
  article-title: Measuring social attention and motivation in autism spectrum disorder using eye-tracking: Stimulus type matters
  publication-title: Autism Res.
  doi: 10.1002/aur.1479
  contributor:
    fullname: Chevallier
– volume: 57
  start-page: 93
  year: 2016
  end-page: 102
  ident: CR86
  article-title: Examining the phenotypic heterogeneity of early autism spectrum disorder: Subtypes and short-term outcomes
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/jcpp.12448
  contributor:
    fullname: Chawarska
– volume: 4
  start-page: 149
  year: 1971
  end-page: 154
  ident: CR101
  article-title: Novelty, familiarity, and the development of infant attention
  publication-title: Dev. Psychol.
  doi: 10.1037/h0030432
  contributor:
    fullname: Pratt
– volume: 17
  start-page: 355
  year: 2012
  end-page: 375
  ident: CR99
  article-title: Measuring the development of social attention using free-viewing
  publication-title: Infancy
  doi: 10.1111/j.1532-7078.2011.00086.x
  contributor:
    fullname: Saxe
– volume: 24
  start-page: 88
  year: 2019
  end-page: 107
  ident: CR5
  article-title: The ASD living biology: from cell proliferation to clinical phenotype
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-018-0056-y
  contributor:
    fullname: Courchesne
– volume: 11
  start-page: 1
  year: 2020
  end-page: 17
  ident: CR37
  article-title: Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: A comparative study
  publication-title: Mol. Autism
  doi: 10.1186/s13229-020-00321-w
  contributor:
    fullname: Fujioka
– volume: 98
  start-page: 1248
  year: 2008
  end-page: 1255
  ident: CR49
  article-title: Gender and race/ethnicity differences in lead dose biomarkers
  publication-title: Am. J. Public Health
  doi: 10.2105/AJPH.2007.118505
  contributor:
    fullname: Theppeang
– volume: 44
  start-page: 584
  year: 2014
  end-page: 592
  ident: CR13
  article-title: Visual attention to competing social and object images by preschool children with autism spectrum disorder
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-013-1910-z
  contributor:
    fullname: Touchstone
– volume: 12
  start-page: 1
  year: 2017
  end-page: 13
  ident: CR38
  article-title: Developing an eye-tracking algorithm as a potential tool for early diagnosis of autism spectrum disorder in children
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0188826
  contributor:
    fullname: Vargas-Cuentas
– volume: 9
  start-page: 1
  year: 2018
  end-page: 13
  ident: CR17
  article-title: The geometric preference subtype in ASD: Identifying a consistent, early-emerging phenomenon through eye tracking
  publication-title: Mol. Autism
  doi: 10.1186/s13229-018-0202-z
  contributor:
    fullname: Moore
– volume: 6
  start-page: 25776
  year: 2016
  ident: CR54
  article-title: Evaluation of prostate cancer antigen 3 for detecting prostate cancer: A systematic review and meta-analysis
  publication-title: Sci. Rep.
  doi: 10.1038/srep25776
  contributor:
    fullname: Cui
– volume: 63
  start-page: 1
  year: 2014
  end-page: 21
  ident: CR81
  article-title: Prevalence of Autism Spectrum Disorder among children aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2010
  publication-title: Surv. Summ.
  contributor:
    fullname: Baio
– volume: 68
  start-page: 101
  year: 2011
  end-page: 109
  ident: CR25
  article-title: Preference for geometric patterns early in life as a risk factor for autism
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archgenpsychiatry.2010.113
  contributor:
    fullname: Desmond
– volume: 135
  start-page: 3
  year: 1979
  end-page: 9
  ident: CR104
  article-title: Responses to social and inanimate stimuli in early infancy
  publication-title: J. Genet. Psychol.
  doi: 10.1080/00221325.1979.10533411
  contributor:
    fullname: Jennings
– volume: 40
  start-page: 41
  year: 2020
  end-page: 63
  ident: CR90
  article-title: A deficit in using prosodic cues to understand communicative intentions by children with autism spectrum disorders: An eye-tracking study
  publication-title: First Lang.
  doi: 10.1177/0142723719885270
  contributor:
    fullname: Zhan
– volume: 86
  start-page: 567
  year: 2015
  end-page: 577
  ident: CR85
  article-title: Different functional neural substrates for good and poor language outcome in Autism
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.03.023
  contributor:
    fullname: Lombardo
– volume: 547
  start-page: 340
  year: 2017
  end-page: 344
  ident: CR59
  article-title: Infant viewing of social scenes is under genetic control and is atypical in autism
  publication-title: Nature
  doi: 10.1038/nature22999
  contributor:
    fullname: Constantino
– volume: 30
  start-page: 197
  year: 2018
  end-page: 215
  ident: CR75
  article-title: Multiple predicting K-fold cross-validation for model selection
  publication-title: Journal of Nonparametric Statistics
  doi: 10.1080/10485252.2017.1404598
  contributor:
    fullname: Jung
– volume: 15
  start-page: 55
  year: 1985
  end-page: 76
  ident: CR103
  article-title: Event-related brain potential correlates of the processing of novel visual and auditory information in autism
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/BF01837899
  contributor:
    fullname: Galambos
– year: 2021
  ident: CR110
  article-title: Clinical profiles of black and white children referred for autism diagnosis
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-021-05019-3
  contributor:
    fullname: Zuckerman
– year: 2002
  ident: CR60
  publication-title: Communication and symbolic behavior scales: Developmental profile
  contributor:
    fullname: Prizant
– volume: 43
  start-page: 326
  year: 2020
  end-page: 342
  ident: CR2
  article-title: Prenatal origins of ASD: The when, what, and how of ASD development
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2020.03.005
  contributor:
    fullname: Lewis
– volume: 14
  start-page: 1
  year: 2020
  end-page: 7
  ident: CR8
  article-title: The autism biomarkers consortium for clinical trials (ABC-CT): Scientific context, study design, and progress toward biomarker qualification
  publication-title: Front. Integr. Neurosci.
  doi: 10.3389/fnint.2020.00016
  contributor:
    fullname: McPartland
– volume: 318
  start-page: 1349
  year: 1988
  end-page: 1354
  ident: CR77
  article-title: Hypoplasia of cerebellar vermal lobules VI and VII in Autism
  publication-title: N. Engl. J. Med.
  doi: 10.1056/nejm198805263182102
  contributor:
    fullname: Jernigan
– ident: CR66
– volume: 45
  start-page: 222
  year: 2020
  end-page: 235
  ident: CR91
  article-title: Rapid eye-tracking evaluation oflanguage in children and adolescents referred for assessment of neurodevelopmental disorders
  publication-title: J. Intellect. Dev. Disabil.
  doi: 10.3109/13668250.2019.1698287
  contributor:
    fullname: Frazier
– volume: 51
  start-page: 1353
  year: 2021
  end-page: 1364
  ident: CR109
  article-title: Sex/gender differences in camouflaging in children and adolescents with autism
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-020-04615-z
  contributor:
    fullname: Wood-Downie
– ident: CR89
– volume: 53
  start-page: 903
  year: 2012
  end-page: 913
  ident: CR27
  article-title: Context modulates attention to social scenes in toddlers with autism
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/j.1469-7610.2012.02538.x
  contributor:
    fullname: Shic
– volume: 79
  start-page: 657
  year: 2016
  end-page: 666
  ident: CR16
  article-title: Eye tracking reveals abnormal visual preference for geometric images as an early biomarker of an autism spectrum disorder subtype associated with increased symptom severity
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2015.03.032
  contributor:
    fullname: Pierce
– volume: 74
  start-page: 195
  year: 2013
  end-page: 203
  ident: CR28
  article-title: Decreased spontaneous attention to social scenes in 6-month-old infants later diagnosed with autism spectrum disorders
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2012.11.022
  contributor:
    fullname: Shic
– volume: 16
  start-page: e0252795
  year: 2021
  ident: CR35
  article-title: Visual preference for social vs. non-social images in young children with autism spectrum disorders. An eye tracking study
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0252795
  contributor:
    fullname: Cuadrado
– volume: 36
  start-page: 453
  year: 1965
  ident: CR106
  article-title: Children's preferences for differing degrees of novelty
  publication-title: Child Dev.
  doi: 10.2307/1126468
  contributor:
    fullname: Mendel
– volume: 68
  start-page: 88
  year: 2017
  end-page: 94
  ident: CR47
  article-title: Eye gaze and pupillary response in Angelman syndrome
  publication-title: Res. Dev. Disabil.
  doi: 10.1016/j.ridd.2017.06.011
  contributor:
    fullname: Hong
– volume: 51
  start-page: 431
  year: 2019
  end-page: 444
  ident: CR80
  article-title: Identification of common genetic risk variants for autism spectrum disorder
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0344-8
  contributor:
    fullname: Grove
– volume: 26
  start-page: 617
  year: 2021
  end-page: 634
  ident: CR45
  article-title: Longitudinal assessment of social attention in preterm and term infants: Its relation to social communication and language outcome
  publication-title: Infancy
  doi: 10.1111/infa.12402
  contributor:
    fullname: Myowa
– ident: CR69
– volume: 29
  start-page: 30
  year: 2018
  end-page: 40
  ident: CR96
  article-title: Cascading effects of attention disengagement and sensory seeking on social symptoms in a community sample of infants at-risk for a future diagnosis of autism spectrum disorder
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2017.08.006
  contributor:
    fullname: Baranek
– volume: 57
  start-page: 858
  year: 2018
  end-page: 866
  ident: CR82
  article-title: Development and validation of objective and quantitative eye tracking−based measures of autism risk and symptom levels
  publication-title: J. Am. Acad. Child Adolesc. Psychiatry
  doi: 10.1016/j.jaac.2018.06.023
  contributor:
    fullname: Frazier
– volume: 5
  start-page: 1
  year: 2013
  end-page: 12
  ident: CR55
  article-title: Social and emotional processing in Prader-Willi syndrome: Genetic subtype differences
  publication-title: J. Neurodev. Disord.
  doi: 10.1186/1866-1955-5-7
  contributor:
    fullname: Dykens
– volume: 504
  start-page: 427
  year: 2013
  end-page: 431
  ident: CR29
  article-title: Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism
  publication-title: Nature
  doi: 10.1038/nature12715
  contributor:
    fullname: Klin
– volume: 459
  start-page: 257
  year: 2009
  end-page: 261
  ident: CR23
  article-title: Two-year-olds with autism orient to non-social contingencies rather than biological motion
  publication-title: Nature
  doi: 10.1038/nature07868
  contributor:
    fullname: Jones
– volume: 15
  year: 2019
  ident: CR76
  article-title: Effects of biomarker diagnostic accuracy on biomarker-guided phase 2 trials
  publication-title: Contemp. Clin. Trials Commun.
  doi: 10.1016/j.conctc.2019.100396
  contributor:
    fullname: Thorlund
– volume: 10
  start-page: 74
  year: 2014
  end-page: 81
  ident: CR83
  article-title: Disentangling the heterogeneity of autism spectrum disorder through genetic findings
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/nrneurol.2013.278
  contributor:
    fullname: Geschwind
– year: 2021
  ident: CR36
  article-title: A study on visual preference for social stimuli in typical Ecuadorian preschoolers as a contribution to the identification of autism risk factors
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-87888-3
  contributor:
    fullname: Gentaz
– volume: 30
  start-page: 283
  year: 2021
  end-page: 291
  ident: CR95
  article-title: Sensory processing related to attention in children with ASD, ADHD, or typical development: results from the ELENA cohort
  publication-title: Eur. Child Adolesc. Psychiatry
  doi: 10.1007/s00787-020-01516-5
  contributor:
    fullname: Dellapiazza
– volume: 21
  start-page: 772
  year: 2017
  end-page: 784
  ident: CR113
  article-title: The clinician perspective on sex differences in autism spectrum disorders
  publication-title: Autism
  doi: 10.1177/1362361316681481
  contributor:
    fullname: Halladay
– volume: 3
  start-page: 293
  year: 2010
  end-page: 302
  ident: CR115
  article-title: Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study
  publication-title: Autism Res.
  doi: 10.1002/aur.156
  contributor:
    fullname: Lerer
– volume: 46
  start-page: 1
  year: 2012
  end-page: 17
  ident: CR71
  article-title: Fast R functions for robust correlations and hierarchical clustering
  publication-title: J. Stat. Softw.
  doi: 10.18637/jss.v046.i11
  contributor:
    fullname: Langfelder
– volume: 50
  start-page: 4412
  year: 2020
  end-page: 4430
  ident: CR46
  article-title: Exploring social biomarkers in high-functioning adults with autism and Asperger’s versus healthy controls: A cross-sectional analysis
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-020-04493-5
  contributor:
    fullname: Del Valle Rubido
– volume: 47
  start-page: 506
  year: 2017
  end-page: 513
  ident: CR42
  article-title: Brief report: Diminished gaze preference for dynamic social interaction scenes in youth with autism spectrum disorders
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-016-2975-2
  contributor:
    fullname: Shaffer
– volume: 59
  start-page: 809
  year: 2002
  end-page: 816
  ident: CR11
  article-title: Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.59.9.809
  contributor:
    fullname: Cohen
– ident: CR111
– volume: 11
  start-page: 1635
  year: 2018
  end-page: 1642
  ident: CR1
  article-title: Autism is a prenatal disorder: Evidence from late gestation brain overgrowth
  publication-title: Autism Res.
  doi: 10.1002/aur.2036
  contributor:
    fullname: Bonnet-Brilhault
– year: 1995
  ident: CR62
  publication-title: Autism diagnostic observation schedule
  contributor:
    fullname: Lord
– volume: 4
  start-page: e210771
  year: 2021
  ident: CR112
  article-title: Racial/ethnic disparities in the prevalence and trends of Autism Spectrum Disorder in US children and adolescents
  publication-title: JAMA Netw. Open
  doi: 10.1001/jamanetworkopen.2021.0771
  contributor:
    fullname: Lu
– volume: 24
  start-page: 658
  year: 2020
  end-page: 669
  ident: CR20
  article-title: Identifying prognostic markers in autism spectrum disorder using eye tracking
  publication-title: Autism
  doi: 10.1177/1362361319878578
  contributor:
    fullname: Bacon
– volume: 10
  start-page: 1
  year: 2016
  end-page: 12
  ident: CR15
  article-title: Social orienting and attention is influenced by the presence of competing nonsocial information in adolescents with autism
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2016.00586
  contributor:
    fullname: Unruh
– year: 2020
  ident: CR48
  article-title: Oxytocin biases eye-gaze to dynamic and static social images and the eyes of fearful faces: Associations with trait autism
  publication-title: Transl. Psychiatr.
  doi: 10.1038/s41398-020-0830-x
  contributor:
    fullname: Le
– volume: 22
  start-page: 345
  year: 2016
  end-page: 361
  ident: CR6
  article-title: Advancing the understanding of autism disease mechanisms through genetics
  publication-title: Nat. Med.
  doi: 10.1038/nm.4071
  contributor:
    fullname: Geschwind
– volume: 11
  start-page: 1
  year: 2020
  end-page: 14
  ident: CR21
  article-title: Social attention to activities in children and adults with autism spectrum disorder: effects of context and age
  publication-title: Mol. Autism
  doi: 10.1186/s13229-020-00388-5
  contributor:
    fullname: Kaliukhovich
– volume: 48
  start-page: 79
  year: 2016
  end-page: 93
  ident: CR30
  article-title: Social attention in ASD: A review and meta-analysis of eye-tracking studies
  publication-title: Res. Dev. Disabil.
  doi: 10.1016/j.ridd.2015.10.011
  contributor:
    fullname: Chita-Tegmark
– volume: 10
  start-page: 1
  year: 2015
  end-page: 16
  ident: CR44
  article-title: Different visual preference patterns in response to simple and complex dynamic social stimuli in preschool-aged children with autism spectrum disorders
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0122280
  contributor:
    fullname: Shi
– year: 1984
  ident: CR63
  publication-title: Vineland Scales of Adaptive Behavior, survey form manual
  contributor:
    fullname: Cicchetti
– volume: 56
  start-page: 544
  year: 1975
  end-page: 549
  ident: CR98
  article-title: Visual following and pattern discrimination of face like stimuli by newborn infants
  publication-title: Pediatrics
  doi: 10.1542/peds.56.4.544
  contributor:
    fullname: Wu
– volume: 387
  start-page: 167
  year: 1997
  end-page: 178
  ident: CR105
  article-title: Regional differences in synaptogenesisin human cerebral cortex
  publication-title: J. Comp. Neurol.
  doi: 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z
  contributor:
    fullname: Dabholkar
– year: 2021
  ident: CR7
  article-title: Evidence-based use of scalable biomarkers to increase diagnostic efficiency and decrease the lifetime costs of autism
  publication-title: Autism Res.
  doi: 10.1002/aur.2498
  contributor:
    fullname: Frazier
– volume: 67
  start-page: 1
  year: 2018
  end-page: 23
  ident: CR4
  article-title: Prevalence of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014
  publication-title: MMWR Surveill. Summ.
  doi: 10.15585/mmwr.ss6706a1
  contributor:
    fullname: Baio
– volume: 29
  start-page: 41
  year: 2018
  end-page: 53
  ident: CR97
  article-title: Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2017.08.005
  contributor:
    fullname: Damiano-Goodwin
– volume: 65
  start-page: 946
  year: 2008
  end-page: 954
  ident: CR22
  article-title: Absence of preferential looking to the eyes of approaching adults predicts level of social disability in 2-year-old toddlers with autism spectrum disorder
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.65.8.946
  contributor:
    fullname: Klin
– ident: CR32
– volume: 178
  start-page: 77
  year: 2021
  end-page: 86
  ident: CR84
  article-title: A genetics-first approach to dissecting the heterogeneity of autism: Phenotypic comparison of autism risk copy number variants
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2020.20010015
  contributor:
    fullname: Chawner
– year: 2008
  ident: CR72
  article-title: WGCNA: An R package for weighted correlation network analysis
  publication-title: BMC Bioinform.
  doi: 10.1186/1471-2105-9-559
  contributor:
    fullname: Langfelder
– year: 1995
  ident: CR61
  publication-title: Mullen scales of early learning
  contributor:
    fullname: Mullen
– volume: 56
  start-page: 321
  year: 2018
  end-page: 336
  ident: CR114
  article-title: ‘‘We Had to Keep Pushing’’: Caregivers’ perspectives on autism screening and referral practices of black children in primary care
  publication-title: Intellect. Dev. Disabil.
  doi: 10.1352/1934-9556-56.5.321
  contributor:
    fullname: Nichols
– volume: 6
  start-page: e808
  year: 2016
  end-page: e808
  ident: CR51
  article-title: Disentangling the initiation from the response in joint attention: An eye-tracking study in toddlers with autism spectrum disorders
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2016.75
  contributor:
    fullname: Billeci
– ident: CR64
– volume: 78
  year: 2020
  ident: CR41
  article-title: Orientation to and processing of social stimuli under normal and competitive conditions in children with autism spectrum disorder
  publication-title: Res. Autism Spectr. Disord.
  doi: 10.1016/j.rasd.2020.101614
  contributor:
    fullname: Feng
– year: 2018
  ident: CR53
  article-title: Clinical value of RNA sequencing–based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter Sweden Cancerome Analysis Network—Breast Initiative
  publication-title: JCO Precis. Oncol.
  doi: 10.1200/po.17.00135
  contributor:
    fullname: Brueffer
– volume: 1
  start-page: 31
  year: 2008
  end-page: 42
  ident: CR12
  article-title: Children with autism demonstrate circumscribed attention during passive viewing of complex social and nonsocial picture arrays
  publication-title: Autism Res.
  doi: 10.1002/aur.4
  contributor:
    fullname: Bodfish
– volume: 302
  start-page: 385
  year: 2009
  ident: CR52
  article-title: CSF biomarkers and incipient alzheimer disease in patients with mild cognitive impairment
  publication-title: JAMA
  doi: 10.1001/jama.2009.1064
  contributor:
    fullname: Mattsson
– volume: 12
  start-page: 779
  year: 2019
  end-page: 793
  ident: CR43
  article-title: The use of eye tracking as a biomarker of treatment outcome in a pilot randomized clinical trial for young children with autism
  publication-title: Autism Res.
  doi: 10.1002/aur.2093
  contributor:
    fullname: Bradshaw
– volume: 87
  start-page: 102033
  year: 2021
  ident: CR88
  article-title: Validation strategies for subtypes in psychiatry: A systematic review of research on autism spectrum disorder
  publication-title: Clin. Psychol. Rev.
  doi: 10.1016/j.cpr.2021.102033
  contributor:
    fullname: Geurts
– volume: 117
  start-page: 131
  year: 1970
  end-page: 146
  ident: CR100
  article-title: Attentional preference and experience: I. Introduction
  publication-title: J. Genet. Psychol.
  doi: 10.1080/00221325.1970.10533940
  contributor:
    fullname: Hunt
– ident: CR79
– volume: 18
  start-page: 704
  year: 1982
  end-page: 713
  ident: CR102
  article-title: Familiarity and novelty preferences in infant recognition memory: Implications for information processing
  publication-title: Dev. Psychol.
  doi: 10.1037//0012-1649.18.5.704
  contributor:
    fullname: Bridger
– year: 2018
  ident: CR18
  article-title: A scalable off-the-shelf framework for measuring patterns of attention in young children and its application in Autism Spectrum Disorder
  publication-title: IEEE Trans. Affect. Comput.
  doi: 10.1109/TAFFC.2018.2890610
  contributor:
    fullname: Sapiro
– volume: 14
  start-page: 2143
  year: 2021
  end-page: 2155
  ident: CR93
  article-title: Social and non-social sensory responsivity in toddlers at high-risk for autism spectrum disorder
  publication-title: Autism Res.
  doi: 10.1002/aur.2556
  contributor:
    fullname: Gunderson
– volume: 13
  start-page: 417
  year: 2002
  end-page: 423
  ident: CR78
  article-title: Perinatal risk factors for infantile autism
  publication-title: Epidemiology
  doi: 10.1097/00001648-200207000-00009
  contributor:
    fullname: Cnattingius
– year: 2021
  ident: CR34
  article-title: Computational methods to measure patterns of gaze in toddlers with autism spectrum disorder
  publication-title: JAMA Pediatr.
  doi: 10.1001/jamapediatrics.2021.0530
  contributor:
    fullname: Chang
– volume: 3
  start-page: 6
  year: 2019
  end-page: 8
  ident: CR57
  article-title: Face processing and exploration of social signals in Prader–Willi syndrome: a genetic signature
  publication-title: Orphanet J Rare Dis
  contributor:
    fullname: Debladis
– ident: CR73
– ident: CR65
– volume: 12
  start-page: 77
  year: 2011
  ident: CR68
  article-title: pROC: an open-source package for R and S+ to analyze and compare ROC curves
  publication-title: Bioinformatics
  doi: 10.1186/1471-2105-12-77
  contributor:
    fullname: Mülle
– volume: 112
  start-page: E5434
  year: 2015
  end-page: E5442
  ident: CR56
  article-title: Genetic variation in CD38 and breastfeeding experience interact to impact infants' attention to social eye cues
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1506352112
  contributor:
    fullname: Grossmann
– volume: 40
  start-page: 628
  year: 2019
  end-page: 637
  ident: CR87
  article-title: Parsing brain structural heterogeneity in males with autism spectrum disorder reveals distinct clinical subtypes
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.24400
  contributor:
    fullname: Chen
– volume: 8
  start-page: 1
  year: 2019
  end-page: 22
  ident: CR31
  article-title: Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties
  publication-title: Elife
  doi: 10.7554/eLife.47427
  contributor:
    fullname: Lombardo
– volume: 45
  start-page: 1235
  year: 2004
  end-page: 1245
  ident: CR9
  article-title: Event-related brain potentials reveal anomalies in temporal processing of faces in autism spectrum disorder
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/j.1469-7610.2004.00318.x
  contributor:
    fullname: Carver
– volume: 50
  start-page: 924
  year: 2020
  end-page: 934
  ident: CR40
  article-title: Examining how types of object distractors distinctly compete for facial attention in Autism Spectrum Disorder using eye tracking
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-019-04315-3
  contributor:
    fullname: Slane
– volume: 3
  start-page: 129
  year: 2012
  end-page: 137
  ident: CR70
  article-title: Guidelines for estimating repeatability
  publication-title: Methods Ecol. Evol.
  doi: 10.1111/j.2041-210X.2011.00125.x
  contributor:
    fullname: Paulsen
– volume: 25
  start-page: 307
  year: 2013
  end-page: 320
  ident: CR94
  article-title: Hyporesponsiveness to social and nonsocial sensory stimuli in children with autism, children with developmental delays, and typically developing children
  publication-title: Dev. Psychopathol.
  doi: 10.1017/s0954579412001071
  contributor:
    fullname: Baranek
– volume: 82
  start-page: 1
  year: 2017
  end-page: 21
  ident: CR67
  article-title: ThresholdROC: Optimum threshold estimation tools for continuous diagnostic tests in R
  publication-title: J. Stat. Softw.
  doi: 10.18637/jss.v082.i04
  contributor:
    fullname: Carrasco
– volume: 69
  start-page: 1
  year: 2020
  end-page: 12
  ident: CR3
  article-title: Prevalence of autism spectrum disorder among children aged 8 Years—Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016
  publication-title: MMWR Surveill. Summ.
  doi: 10.15585/mmwr.ss6904a1
  contributor:
    fullname: Maenner
– volume: 11
  start-page: 1554
  year: 2018
  end-page: 1566
  ident: CR92
  article-title: Visual exploration in Autism Spectrum Disorder: Exploring age differences and dynamic features using recurrence quantification analysis
  publication-title: Autism. Res.
  doi: 10.1002/aur.2021
  contributor:
    fullname: Manyakov
– volume: 20
  start-page: 628
  year: 2016
  end-page: 634
  ident: CR108
  article-title: Gender ratio in a clinical population sample, age of diagnosis and duration of assessment in children and adults with autism spectrum disorder
  publication-title: Autism
  doi: 10.1177/1362361315617879
  contributor:
    fullname: Rutherford
– volume: 11
  start-page: 1
  year: 2019
  end-page: 10
  ident: CR19
  article-title: Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis: A pilot study
  publication-title: J. Neurodev. Disord.
  doi: 10.1186/s11689-019-9262-4
  contributor:
    fullname: Hong
– volume: 6
  start-page: 842
  year: 2012
  end-page: 851
  ident: CR26
  article-title: Age trends in visual exploration of social and nonsocial information in children with autism
  publication-title: Res. Autism Spectr. Disord.
  doi: 10.1016/j.rasd.2011.11.005
  contributor:
    fullname: Bodfish
– volume: 87
  start-page: 102033
  year: 2021
  ident: 8102_CR88
  publication-title: Clin. Psychol. Rev.
  doi: 10.1016/j.cpr.2021.102033
  contributor:
    fullname: JA Agelink Van Rentergem
– volume: 26
  start-page: 617
  year: 2021
  ident: 8102_CR45
  publication-title: Infancy
  doi: 10.1111/infa.12402
  contributor:
    fullname: M Imafuku
– ident: 8102_CR111
  doi: 10.1016/j.rasd.2021.101745
– volume: 112
  start-page: E5434
  year: 2015
  ident: 8102_CR56
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1506352112
  contributor:
    fullname: KM Krol
– volume: 11
  start-page: 1554
  year: 2018
  ident: 8102_CR92
  publication-title: Autism. Res.
  doi: 10.1002/aur.2021
  contributor:
    fullname: NV Manyakov
– volume: 79
  start-page: 657
  year: 2016
  ident: 8102_CR16
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2015.03.032
  contributor:
    fullname: K Pierce
– year: 2021
  ident: 8102_CR34
  publication-title: JAMA Pediatr.
  doi: 10.1001/jamapediatrics.2021.0530
  contributor:
    fullname: Z Chang
– volume: 14
  start-page: 2143
  year: 2021
  ident: 8102_CR93
  publication-title: Autism Res.
  doi: 10.1002/aur.2556
  contributor:
    fullname: J Gunderson
– volume: 50
  start-page: 475
  year: 2020
  ident: 8102_CR58
  publication-title: Psychol. Med.
  doi: 10.1017/S003329171900031X
  contributor:
    fullname: L Wang
– volume: 43
  start-page: 326
  year: 2020
  ident: 8102_CR2
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2020.03.005
  contributor:
    fullname: E Courchesne
– volume: 11
  start-page: 1
  year: 2020
  ident: 8102_CR37
  publication-title: Mol. Autism
  doi: 10.1186/s13229-020-00321-w
  contributor:
    fullname: T Fujioka
– ident: 8102_CR69
– volume: 57
  start-page: 858
  year: 2018
  ident: 8102_CR82
  publication-title: J. Am. Acad. Child Adolesc. Psychiatry
  doi: 10.1016/j.jaac.2018.06.023
  contributor:
    fullname: TW Frazier
– volume: 50
  start-page: 924
  year: 2020
  ident: 8102_CR40
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-019-04315-3
  contributor:
    fullname: AJ Harrison
– volume: 5
  start-page: 1
  year: 2013
  ident: 8102_CR55
  publication-title: J. Neurodev. Disord.
  doi: 10.1186/1866-1955-5-7
  contributor:
    fullname: AP Key
– volume: 459
  start-page: 257
  year: 2009
  ident: 8102_CR23
  publication-title: Nature
  doi: 10.1038/nature07868
  contributor:
    fullname: A Klin
– volume: 18
  start-page: 704
  year: 1982
  ident: 8102_CR102
  publication-title: Dev. Psychol.
  doi: 10.1037//0012-1649.18.5.704
  contributor:
    fullname: SA Rose
– volume: 98
  start-page: 1248
  year: 2008
  ident: 8102_CR49
  publication-title: Am. J. Public Health
  doi: 10.2105/AJPH.2007.118505
  contributor:
    fullname: K Theppeang
– year: 2008
  ident: 8102_CR72
  publication-title: BMC Bioinform.
  doi: 10.1186/1471-2105-9-559
  contributor:
    fullname: PHS Langfelder
– volume: 53
  start-page: 903
  year: 2012
  ident: 8102_CR27
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/j.1469-7610.2012.02538.x
  contributor:
    fullname: K Chawarska
– volume: 51
  start-page: 994
  year: 2021
  ident: 8102_CR39
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-021-04878-0
  contributor:
    fullname: K Jensen
– ident: 8102_CR66
– volume: 82
  start-page: 1
  year: 2017
  ident: 8102_CR67
  publication-title: J. Stat. Softw.
  doi: 10.18637/jss.v082.i04
  contributor:
    fullname: S Perez-Jaume
– volume: 6
  start-page: 25776
  year: 2016
  ident: 8102_CR54
  publication-title: Sci. Rep.
  doi: 10.1038/srep25776
  contributor:
    fullname: Y Cui
– volume: 51
  start-page: 431
  year: 2019
  ident: 8102_CR80
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0344-8
  contributor:
    fullname: J Grove
– volume: 6
  start-page: e808
  year: 2016
  ident: 8102_CR51
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2016.75
  contributor:
    fullname: L Billeci
– volume: 48
  start-page: 79
  year: 2016
  ident: 8102_CR30
  publication-title: Res. Dev. Disabil.
  doi: 10.1016/j.ridd.2015.10.011
  contributor:
    fullname: M Chita-Tegmark
– volume: 504
  start-page: 427
  year: 2013
  ident: 8102_CR29
  publication-title: Nature
  doi: 10.1038/nature12715
  contributor:
    fullname: W Jones
– year: 2018
  ident: 8102_CR53
  publication-title: JCO Precis. Oncol.
  doi: 10.1200/po.17.00135
  contributor:
    fullname: C Brueffer
– volume: 547
  start-page: 340
  year: 2017
  ident: 8102_CR59
  publication-title: Nature
  doi: 10.1038/nature22999
  contributor:
    fullname: JN Constantino
– year: 2018
  ident: 8102_CR18
  publication-title: IEEE Trans. Affect. Comput.
  doi: 10.1109/TAFFC.2018.2890610
  contributor:
    fullname: MDMJ Bovery
– volume: 4
  start-page: 149
  year: 1971
  ident: 8102_CR101
  publication-title: Dev. Psychol.
  doi: 10.1037/h0030432
  contributor:
    fullname: F Weizmann
– volume: 36
  start-page: 453
  year: 1965
  ident: 8102_CR106
  publication-title: Child Dev.
  doi: 10.2307/1126468
  contributor:
    fullname: G Mendel
– year: 2021
  ident: 8102_CR7
  publication-title: Autism Res.
  doi: 10.1002/aur.2498
  contributor:
    fullname: TW Frazier
– volume: 15
  year: 2019
  ident: 8102_CR76
  publication-title: Contemp. Clin. Trials Commun.
  doi: 10.1016/j.conctc.2019.100396
  contributor:
    fullname: JJ Park
– volume: 21
  start-page: 772
  year: 2017
  ident: 8102_CR113
  publication-title: Autism
  doi: 10.1177/1362361316681481
  contributor:
    fullname: R Jamison
– volume: 11
  start-page: 1635
  year: 2018
  ident: 8102_CR1
  publication-title: Autism Res.
  doi: 10.1002/aur.2036
  contributor:
    fullname: F Bonnet-Brilhault
– volume: 2
  start-page: 217
  year: 1943
  ident: 8102_CR10
  publication-title: Nervous Child
  contributor:
    fullname: L Kanner
– volume: 69
  start-page: 1
  year: 2020
  ident: 8102_CR3
  publication-title: MMWR Surveill. Summ.
  doi: 10.15585/mmwr.ss6904a1
  contributor:
    fullname: MJ Maenner
– volume-title: Communication and symbolic behavior scales: Developmental profile
  year: 2002
  ident: 8102_CR60
  contributor:
    fullname: AM Wetherby
– volume: 68
  start-page: 101
  year: 2011
  ident: 8102_CR25
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archgenpsychiatry.2010.113
  contributor:
    fullname: K Pierce
– volume: 16
  start-page: e0252795
  year: 2021
  ident: 8102_CR35
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0252795
  contributor:
    fullname: J Vacas
– volume: 65
  start-page: 946
  year: 2008
  ident: 8102_CR22
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.65.8.946
  contributor:
    fullname: W Jones
– volume: 45
  start-page: 222
  year: 2020
  ident: 8102_CR91
  publication-title: J. Intellect. Dev. Disabil.
  doi: 10.3109/13668250.2019.1698287
  contributor:
    fullname: TW Frazier
– volume: 3
  start-page: 129
  year: 2012
  ident: 8102_CR70
  publication-title: Methods Ecol. Evol.
  doi: 10.1111/j.2041-210X.2011.00125.x
  contributor:
    fullname: ME Wolak
– volume: 17
  start-page: 355
  year: 2012
  ident: 8102_CR99
  publication-title: Infancy
  doi: 10.1111/j.1532-7078.2011.00086.x
  contributor:
    fullname: MC Frank
– volume: 3
  start-page: 6
  year: 2019
  ident: 8102_CR57
  publication-title: Orphanet J Rare Dis
  contributor:
    fullname: J Debladis
– year: 2021
  ident: 8102_CR110
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-021-05019-3
  contributor:
    fullname: E Fombonne
– volume: 29
  start-page: 30
  year: 2018
  ident: 8102_CR96
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2017.08.006
  contributor:
    fullname: GT Baranek
– volume: 56
  start-page: 544
  year: 1975
  ident: 8102_CR98
  publication-title: Pediatrics
  doi: 10.1542/peds.56.4.544
  contributor:
    fullname: CC Goren
– volume: 40
  start-page: 41
  year: 2020
  ident: 8102_CR90
  publication-title: First Lang.
  doi: 10.1177/0142723719885270
  contributor:
    fullname: P Zhou
– volume: 59
  start-page: 809
  year: 2002
  ident: 8102_CR11
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.59.9.809
  contributor:
    fullname: A Klin
– volume: 24
  start-page: 658
  year: 2020
  ident: 8102_CR20
  publication-title: Autism
  doi: 10.1177/1362361319878578
  contributor:
    fullname: EC Bacon
– volume: 56
  start-page: 321
  year: 2018
  ident: 8102_CR114
  publication-title: Intellect. Dev. Disabil.
  doi: 10.1352/1934-9556-56.5.321
  contributor:
    fullname: S Dababnah
– volume: 68
  start-page: 88
  year: 2017
  ident: 8102_CR47
  publication-title: Res. Dev. Disabil.
  doi: 10.1016/j.ridd.2017.06.011
  contributor:
    fullname: MP Hong
– volume: 30
  start-page: 197
  year: 2018
  ident: 8102_CR75
  publication-title: Journal of Nonparametric Statistics
  doi: 10.1080/10485252.2017.1404598
  contributor:
    fullname: Y Jung
– volume: 8
  start-page: 1
  year: 2019
  ident: 8102_CR31
  publication-title: Elife
  doi: 10.7554/eLife.47427
  contributor:
    fullname: MV Lombardo
– year: 2020
  ident: 8102_CR48
  publication-title: Transl. Psychiatr.
  doi: 10.1038/s41398-020-0830-x
  contributor:
    fullname: J Le
– volume: 10
  start-page: 74
  year: 2014
  ident: 8102_CR83
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/nrneurol.2013.278
  contributor:
    fullname: SS Jeste
– ident: 8102_CR64
– volume: 8
  start-page: 620
  year: 2015
  ident: 8102_CR14
  publication-title: Autism Res.
  doi: 10.1002/aur.1479
  contributor:
    fullname: C Chevallier
– volume: 3
  start-page: 293
  year: 2010
  ident: 8102_CR115
  publication-title: Autism Res.
  doi: 10.1002/aur.156
  contributor:
    fullname: E Lerer
– volume: 318
  start-page: 1349
  year: 1988
  ident: 8102_CR77
  publication-title: N. Engl. J. Med.
  doi: 10.1056/nejm198805263182102
  contributor:
    fullname: E Courchesne
– volume: 10
  start-page: 1
  year: 2015
  ident: 8102_CR44
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0122280
  contributor:
    fullname: L Shi
– volume: 1380
  start-page: 246
  year: 2011
  ident: 8102_CR24
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2010.11.074
  contributor:
    fullname: F Shic
– volume: 12
  start-page: 779
  year: 2019
  ident: 8102_CR43
  publication-title: Autism Res.
  doi: 10.1002/aur.2093
  contributor:
    fullname: J Bradshaw
– volume: 12
  start-page: 1
  year: 2017
  ident: 8102_CR38
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0188826
  contributor:
    fullname: NI Vargas-Cuentas
– volume: 10
  start-page: 1
  year: 2016
  ident: 8102_CR15
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2016.00586
  contributor:
    fullname: KE Unruh
– volume: 15
  start-page: 55
  year: 1985
  ident: 8102_CR103
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/BF01837899
  contributor:
    fullname: E Courchesne
– volume: 63
  start-page: 1
  year: 2014
  ident: 8102_CR81
  publication-title: Surv. Summ.
  contributor:
    fullname: J Baio
– volume-title: Mullen scales of early learning
  year: 1995
  ident: 8102_CR61
  contributor:
    fullname: EM Mullen
– volume: 45
  start-page: 1235
  year: 2004
  ident: 8102_CR9
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/j.1469-7610.2004.00318.x
  contributor:
    fullname: J Mcpartland
– volume: 57
  start-page: 93
  year: 2016
  ident: 8102_CR86
  publication-title: J. Child Psychol. Psychiatry
  doi: 10.1111/jcpp.12448
  contributor:
    fullname: SH Kim
– volume: 6
  start-page: 842
  year: 2012
  ident: 8102_CR26
  publication-title: Res. Autism Spectr. Disord.
  doi: 10.1016/j.rasd.2011.11.005
  contributor:
    fullname: JT Elison
– volume: 24
  start-page: 88
  year: 2019
  ident: 8102_CR5
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-018-0056-y
  contributor:
    fullname: E Courchesne
– volume: 178
  start-page: 77
  year: 2021
  ident: 8102_CR84
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2020.20010015
  contributor:
    fullname: SJRA Chawner
– volume: 74
  start-page: 195
  year: 2013
  ident: 8102_CR28
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2012.11.022
  contributor:
    fullname: K Chawarska
– volume: 47
  start-page: 506
  year: 2017
  ident: 8102_CR42
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-016-2975-2
  contributor:
    fullname: RC Shaffer
– volume: 29
  start-page: 41
  year: 2018
  ident: 8102_CR97
  publication-title: Dev. Cogn. Neurosci.
  doi: 10.1016/j.dcn.2017.08.005
  contributor:
    fullname: CR Damiano-Goodwin
– volume: 86
  start-page: 567
  year: 2015
  ident: 8102_CR85
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.03.023
  contributor:
    fullname: VM Lombardo
– ident: 8102_CR73
– volume: 1
  start-page: 31
  year: 2008
  ident: 8102_CR12
  publication-title: Autism Res.
  doi: 10.1002/aur.4
  contributor:
    fullname: NJ Sasson
– volume: 67
  start-page: 1
  year: 2018
  ident: 8102_CR4
  publication-title: MMWR Surveill. Summ.
  doi: 10.15585/mmwr.ss6706a1
  contributor:
    fullname: J Baio
– volume: 387
  start-page: 167
  year: 1997
  ident: 8102_CR105
  publication-title: J. Comp. Neurol.
  doi: 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z
  contributor:
    fullname: P Huttenlocher
– volume: 51
  start-page: 1353
  year: 2021
  ident: 8102_CR109
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-020-04615-z
  contributor:
    fullname: H Wood-Downie
– volume: 46
  start-page: 1
  year: 2012
  ident: 8102_CR71
  publication-title: J. Stat. Softw.
  doi: 10.18637/jss.v046.i11
  contributor:
    fullname: PHS Langfelder
– ident: 8102_CR79
  doi: 10.1093/acrefore/9780190632366.013.181
– volume: 9
  start-page: 1
  year: 2018
  ident: 8102_CR17
  publication-title: Mol. Autism
  doi: 10.1186/s13229-018-0202-z
  contributor:
    fullname: A Moore
– volume: 11
  start-page: 1
  year: 2019
  ident: 8102_CR19
  publication-title: J. Neurodev. Disord.
  doi: 10.1186/s11689-019-9262-4
  contributor:
    fullname: MP Hong
– year: 2021
  ident: 8102_CR36
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-87888-3
  contributor:
    fullname: P Buffle
– volume: 135
  start-page: 544
  year: 2017
  ident: 8102_CR50
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.023005
  contributor:
    fullname: J Lew
– volume: 53
  start-page: 157
  year: 2011
  ident: 8102_CR107
  publication-title: Dev. Psychobiol.
  doi: 10.1002/dev.20503
  contributor:
    fullname: K Morgan
– volume: 117
  start-page: 131
  year: 1970
  ident: 8102_CR100
  publication-title: J. Genet. Psychol.
  doi: 10.1080/00221325.1970.10533940
  contributor:
    fullname: JM Hunt
– volume: 14
  start-page: 1
  year: 2020
  ident: 8102_CR8
  publication-title: Front. Integr. Neurosci.
  doi: 10.3389/fnint.2020.00016
  contributor:
    fullname: JC McPartland
– volume: 25
  start-page: 307
  year: 2013
  ident: 8102_CR94
  publication-title: Dev. Psychopathol.
  doi: 10.1017/s0954579412001071
  contributor:
    fullname: GT Baranek
– volume: 40
  start-page: 628
  year: 2019
  ident: 8102_CR87
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.24400
  contributor:
    fullname: H Chen
– ident: 8102_CR74
– volume: 159
  start-page: 458
  year: 2011
  ident: 8102_CR33
  publication-title: J. Pediatr.
  doi: 10.1016/j.jpeds.2011.02.036
  contributor:
    fullname: K Pierce
– ident: 8102_CR89
  doi: 10.1101/2021.10.08.463640
– ident: 8102_CR32
  doi: 10.1016/j.jpeds.2021.04.041
– volume: 30
  start-page: 283
  year: 2021
  ident: 8102_CR95
  publication-title: Eur. Child Adolesc. Psychiatry
  doi: 10.1007/s00787-020-01516-5
  contributor:
    fullname: F Dellapiazza
– volume: 78
  year: 2020
  ident: 8102_CR41
  publication-title: Res. Autism Spectr. Disord.
  doi: 10.1016/j.rasd.2020.101614
  contributor:
    fullname: X Wang
– volume: 20
  start-page: 628
  year: 2016
  ident: 8102_CR108
  publication-title: Autism
  doi: 10.1177/1362361315617879
  contributor:
    fullname: M Rutherford
– ident: 8102_CR65
– volume: 135
  start-page: 3
  year: 1979
  ident: 8102_CR104
  publication-title: J. Genet. Psychol.
  doi: 10.1080/00221325.1979.10533411
  contributor:
    fullname: RP Klein
– volume: 11
  start-page: 1
  year: 2020
  ident: 8102_CR21
  publication-title: Mol. Autism
  doi: 10.1186/s13229-020-00388-5
  contributor:
    fullname: DA Kaliukhovich
– volume: 4
  start-page: e210771
  year: 2021
  ident: 8102_CR112
  publication-title: JAMA Netw. Open
  doi: 10.1001/jamanetworkopen.2021.0771
  contributor:
    fullname: J Yuan
– volume-title: Vineland Scales of Adaptive Behavior, survey form manual
  year: 1984
  ident: 8102_CR63
  contributor:
    fullname: S Sparrow
– volume: 13
  start-page: 417
  year: 2002
  ident: 8102_CR78
  publication-title: Epidemiology
  doi: 10.1097/00001648-200207000-00009
  contributor:
    fullname: CM Hultman
– volume: 44
  start-page: 584
  year: 2014
  ident: 8102_CR13
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-013-1910-z
  contributor:
    fullname: NJ Sasson
– volume: 50
  start-page: 4412
  year: 2020
  ident: 8102_CR46
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-020-04493-5
  contributor:
    fullname: M Del Valle Rubido
– volume-title: Autism diagnostic observation schedule
  year: 1995
  ident: 8102_CR62
  contributor:
    fullname: C Lord
– volume: 22
  start-page: 345
  year: 2016
  ident: 8102_CR6
  publication-title: Nat. Med.
  doi: 10.1038/nm.4071
  contributor:
    fullname: L De La Torre-Ubieta
– volume: 12
  start-page: 77
  year: 2011
  ident: 8102_CR68
  publication-title: Bioinformatics
  doi: 10.1186/1471-2105-12-77
  contributor:
    fullname: XTN Robin
– volume: 302
  start-page: 385
  year: 2009
  ident: 8102_CR52
  publication-title: JAMA
  doi: 10.1001/jama.2009.1064
  contributor:
    fullname: N Mattsson
SSID ssj0000529419
Score 2.5360296
Snippet Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to...
Abstract Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be...
Abstract Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 4253
SubjectTerms 692/308/3187
692/53/2421
692/617/375/366/1373
Autism
Biomarkers
Clinical trials
Eye
Humanities and Social Sciences
multidisciplinary
Precision medicine
Primary care
Science
Science (multidisciplinary)
Toddlers
Visual perception
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NT9wwELUqJKReqkJLCQXkSr3RiCR2bOcIVdGqansCiZs18YfgQLYi7IF_3xk7u90trbj0FsUjxZoZe97EnjeMfQwKMYP2UBoZfSkB8KmlZmbeBGmEd5WjAufvP9TsSn69bq_XWn3RnbBMD5wVd-rBuJYOw4L00igJKpiohRBgYuV9TLtv3a4lU5nVu-lk3U1VMpUwpyNGKqomw9wLoyBuA2ojEiXC_r-hzKeXJf84MU2B6OI1ezUhSH6WZ77DXoRhl23nnpKPb5j_Rne7-Yi6Dxzd6DY3TeLzyGHggfiMS9xDeHgMJX7J0a9yTkX4dE_nfhIDdMfxjqcyzPvFHfcTRycfFz39tH3Lri6-XH6elVMrhdIhJHvAONR1jW766KQixjyjjAGnCK1hPgfaqwaaOvoeougrCV7FOqJA3WjVQQVij20N8yHsM45pbI-yYHrppHYKnO589Ig0hKta6At2slSr_ZkZM2w66RbGZiNYNIJNRrCqYOek-ZUksV2nF-gDdvIB-5wPFOxwaTc7LcHRNorIBzF36Ar2YTWMi4dORGAI80WW0QhiNMq8y2ZezQSRKbED4ojecICNqW6ODLc3iaDbYA6MuLlgn5au8nta_1bFwf9QxXv2skk-Lsq6PmRb6CThCGHTQ3-cVsgvlEQU6w
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwELZaUKVeUN8N0MqVemsjkthrO6cKEAhVLaqqInGzJn4UDiR0wx7498w43kXb1221Hmm9nrHn84znG8beB4WYQXsojYy-lAD4aUbNzLwJ0gjvKkcFzl9P1cmZ_Hw-O88BtzE_q1yeiemg9oOjGPleo4hLDqFg--n6V0ldoyi7mltoPGSbTS0pTbt5cHT67fsqykJ5LFm3uVqmEmZvRI9FVWV4B0NviMeBWvNIibj_b2jzz0eTv2VOk0M6fsK2MpLk-5Pqn7IHoX_GHk29JW-fM_-F3njzEXUQOJrT5dQ8iQ-RQ88D8RqXeJbwcBtK_CVHIXNOxfj0XmeexQDNcrziqRxzvrjiPnN18nHRUfD2BTs7PvpxeFLmlgqlQ2h2g_6obRvddNFJRcx5RhkDThFqw3sdaK8aaOroO4iiqyR4FeuIAnWjVQsViJdsox_68JpxvM52KAumk05qp8Dp1kePiEO4agZdwT4sl9VeT8wZNmW8hbGTEiwqwSYlWFWwA1r5lSSxXqcvhvlPmzeR9WDcjBKjQXpplAQVTNRCCDCx8j4WbHepN5u34mjvDadg71bDuIkoMwJ9GBaTjEYwo1Hm1aTm1UwQoRJLII7oNQNYm-r6SH95kYi6Dd6FET8X7OPSVO6n9e-l2P7_v9hhj5tkvaKs6122geoPbxAY3XRvs_XfAQQXDU0
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access(OpenAccess)
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NbxMxELVKERKXim-2FGQkbrCwazu294AQIKoKUU5E6s2a9QetRDeQbSTy75lZ7wYFArconiiO5znzZu15w9izqJEzmAClVSmUCgBfzaiZWbBRWRl85anA-fSzPpmrj2ezsz02tTsaF7DfmdpRP6n58tvLnz_Wb3DDv84l4_ZVj0GICsUwrcIAhztcX2PXhZKKEH860v2s9S0aVTdj7czuj27Fp0HGfxf3_PsK5R_nqEN4Or7FDkZeyd9mINxme7G7w27kTpPruyx8ohvfvEePRI7gusitlPgiceh4JJXjEv9ZeFzHEr_J0wN0TqX5dHtnOZoBgrS_5ENx5nJ1ycOo3Mn7VUuPcu-x-fGHL-9PyrHBQumRqF1hdGoaYUSbvNKko2e1teA1cTjM8sAELUDUKbSQZFspCDrVCQ1qYXQDFcj7bL9bdPEh45jctmgLtlVeGa_BmyakgPxD-moGbcGeT8vqvmcdDTecf0vrshMcOsENTnC6YO9o5TeWpIE9vLFYfnXjlnIBrJ_RMWlUQVmtQEebjJQSbKpCSAU7mvzmJlw5oUmSEDOKpmBPN8O4peicBLq4WGUbg9TGoM2D7ObNTJCvkmYgjpgtAGxNdXukuzgfZLstZsbIpgv2YoLK72n9eykO__8rHrGbYkCvLOv6iO2j--NjpElX7ZMB-78Ax1wPDw
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer_OA刊
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB5BERIXRMsr0CIjcYOIJHZs5wgrqgoVTlTqzZr4IXpotmq6h_57ZpzsokA5cFvFE63lmcl84_F8BngXNWEGE7C0KoVSIdKvli8zCzYqK4OvPDc4f_uuT87U1_P2fKbJ4V6YRf1e2o8jBRhuAqOUiYIXea--Dw_aWldswSu92u2ncMVK1d3cF3P3q4vYkyn678KVfx-P_KNGmkPP8RN4PGNG8WlS8j7ci8MBPJxukbx9CuGUT3OLkVY7CjKci-maJLFOAgcRmcG4pK-GiLexpH_yvDkuuO2eT-Zcz2JIBjheitx4eb25FGFm5RTjpudt2mdwdvzlx-qknC9PKD2BsBuKPF3XmKZPXmnmyLPaWvSa8RllcGiCbrCpU-gxyb5SGHSqEwnUjdEdViifw96wHuJLEJS49iSLtldeGa_Rmy6kQNhC-qrFvoD322V1VxNHhsu1bWndpARHSnBZCU4X8JlXfifJ_Nb5Aandze7iAlrfcgk0qqCsVqijTUZKiTZVIaQCDrd6c7PTja7RTDdI2UJXwNvdMLkL10BwiOvNJGMIthiSeTGpeTcTwqLMB0gjZmEAi6kuR4aLn5mS21LWS0i5gA9bU_k9rX8vxav_E38Nj5pszbKs60PYI3OIRwSJbvo32Rd-AaBNBLA
  priority: 102
  providerName: Springer Nature
Title Large scale validation of an early-age eye-tracking biomarker of an autism spectrum disorder subtype
URI https://link.springer.com/article/10.1038/s41598-022-08102-6
https://www.ncbi.nlm.nih.gov/pubmed/35277549
https://www.proquest.com/docview/2638177299
https://search.proquest.com/docview/2638722479
https://pubmed.ncbi.nlm.nih.gov/PMC8917231
https://doaj.org/article/da8c58902e4d4864a6e8f7333a8f0ddf
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_ajsFeRrtPr23QYG-bG9uSJfmxDS1lLKWMFfImZH2sgcUpcfPQ_74n2c6WfbzsxcTxgYXu5PuddPc7gA-OI2YQVqeSeZsyrfFXGZqZWemYpNZkJhQ4T6_45Q37PCtnO1AOtTAxad_U85Pmx-Kkmd_G3Mq7hRkPeWLj6-lEYoyBuGS8C7uC0l9C9I7Qu6hYXvUFMhmV4xadVCgkw7ALHSB-AULfIgQegfyt2vJHkbb_b1jzz5TJ385Nozu62IfnPY4kp914D2DHNS_gaddZ8uEl2C8hw5u0qAFH0JjmXesksvREN8QFVuMUvyTEPbgU32TChjkJpfghW2fVi2k0ynZBYjHmar0gtmfqJO26Dlu3r-Dm4vzb5DLtGyqkBoHZPXqjqipEUXvDeODNk1xKbXjAbBjVaWF5oYvc21p7WmdMW-5zjwJ5IXilM01fw16zbNxbIBjM1iirZc0ME4ZrIyrrLeINarJS1wl8HKZV3XW8GSqed1OpOn0o1IeK-lA8gbMw8xvJwHkd_1iuvqte88pqacpwLOqYZZIzzZ30qH-qpc-s9QkcDXpT_UJsVcEDBSFGEFUC7zePcQmFcxHduOW6kxEIZQTKvOnUvBnJYCYJiC0D2Brq9hO02kjT3VtpAp8GU_k5rH9Pxbv_ftEhPCuijdM0z49gDy3DHSNiuq9HuE5mYgRPzs6vrr_i3YRPRnH3Aa9TJkdxBT0Cb6kZ_w
link.rule.ids 230,315,733,786,790,870,891,2115,12083,21416,24346,27955,27956,31752,31753,33777,33778,41153,42222,43343,43838,51609,53825,53827,74100,74657
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LbxMxELagCMEF8WahgJG4waq7a8f2nhAgqgBpT62UmzXrR-mhmzbbHPrvO-N1UoXXLYpHiuMZez7PeL5h7H1QiBm0h9LI6EsJgJ8m1MzMmyCN8K5yVOB8cKimx_LHfDLPAbchP6tcn4npoPYLRzHyvUYRlxxCwfbT-UVJXaMou5pbaNxmd6QQkuxcz_UmxkJZLFm3uVamEmZvQH9FNWV4A0NfiIeB2vJHibb_b1jzzyeTv-VNkzvaf8geZBzJP4-Kf8Ruhf4xuzt2lrx6wvyMXnjzATUQOBrT6dg6iS8ih54HYjUu8STh4SqU-EuOAuacSvHptc4yiwEa5XDGUzHmcnXGfWbq5MOqo9DtU3a8_-3o67TMDRVKh8DsEr1R2za66aKTinjzjDIGnCLMhrc60F410NTRdxBFV0nwKtYRBepGqxYqEM_YTr_owwvG8TLboSyYTjqpnQKnWx894g3hqgl0BfuwXlZ7PvJm2JTvFsaOSrCoBJuUYFXBvtDKbySJ8zp9sVie2LyFrAfjJpQWDdJLoySoYKIWQoCJlfexYLtrvdm8EQd7YzYFe7cZxi1EeRHow2I1ymiEMhplno9q3swE8SlxBOKI3jKAraluj_SnvxJNt8GbMKLngn1cm8rNtP69FC___y_esnvTo4OZnX0__PmK3W-SJYuyrnfZDppCeI0Q6bJ7k_bBNUIDDtQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LbxMxELagFagXxJuFAkbiBqvsrh3be0IUGhUoUYWo1Js16wf00N022xz675nZdVKF1y2KR4rjmfF843kx9jooxAzaQ25k9LkEwE9TGmbmTZBGeFc4KnD-OlcHx_LzyfQk5T_1Ka1ydScOF7XvHL2RTypFveQQCtaTmNIijj7O3p1f5DRBiiKtaZzGTbatpZqiI7a9tz8_-rZ-caGYlizrVDlTCDPp0XpRhRn6Y2gZ8WpQG9ZpaOL_N-T5ZwLlb1HUwTjN7rI7CVXy96MY3GM3Qnuf3RrnTF49YP6Q8r15j_wIHEXrdBykxLvIoeWBehzneK_wcBVy_CVHz-ecCvMpd2eRyABFtD_jQ2nmYnnGferbyftlQw-5D9nxbP_7h4M8jVfIHcK0S7RNdV3pqolOKuqiZ5Qx4BQhOPTxQHtVQVVG30AUTSHBq1hGJCgrrWooQDxiW23XhieMo2vbIC2YRjqpnQKnax89og_hiik0GXuzOlZ7PnbRsEP0Wxg7MsEiE-zABKsytkcnv6akDtjDF93ih00KZT0YN6UgaZBeGiVBBRO1EAJMLLyPGdtd8c0mtezttRBl7NV6GRWKoiTQhm450mgENhppHo9sXu8E0Sp1DMQVvSEAG1vdXGlPfw5Nuw36xYilM_Z2JSrX2_r3UTz9_794yW6jEtjDT_Mvz9hONQiyyMtyl22hJITniJcumxdJEX4BuaIUdw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Large+scale+validation+of+an+early-age+eye-tracking+biomarker+of+an+autism+spectrum+disorder+subtype&rft.jtitle=Scientific+reports&rft.au=Wen%2C+Teresa+H&rft.au=Cheng%2C+Amanda&rft.au=Andreason+Charlene&rft.au=Zahiri+Javad&rft.date=2022-03-11&rft.pub=Nature+Publishing+Group&rft.eissn=2045-2322&rft.volume=12&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-022-08102-6&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon