A plant-derived natural photosynthetic system for improving cell anabolism

Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body 1 , 2 . The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an ‘energy currency’ for...

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Published inNature (London) Vol. 612; no. 7940; pp. 546 - 554
Main Authors Chen, Pengfei, Liu, Xin, Gu, Chenhui, Zhong, Peiyu, Song, Nan, Li, Mobai, Dai, Zhanqiu, Fang, Xiangqian, Liu, Zhaoming, Zhang, Jianfeng, Tang, Ruikang, Fan, Shunwu, Lin, Xianfeng
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.12.2022
Nature Publishing Group
Subjects
13/31
13/51
14/19
14/28
14/34
38/91
631/61/490
631/61/54/2295
64/60
Adenosine Triphosphate - metabolism
Arthritis
Biological activity
Biomaterials
Biomedical materials
Cartilage
Cartilage - cytology
Cartilage - metabolism
Cartilage diseases
Cell membranes
Chondrocytes
Chondrocytes - metabolism
Controllability
Disease
Energy
Energy Metabolism
Homeostasis
Humanities and Social Sciences
Humans
Intracellular
Light
Medical treatment
Membrane Fusion
Membranes
Metabolism
multidisciplinary
NADP - metabolism
Nanoparticles
Osteoarthritis
Osteoarthritis - metabolism
Osteoarthritis - pathology
Osteoarthritis - therapy
Particle size
Photosynthesis
Plants
Plants - metabolism
Proteins
Proteomics
Science
Science (multidisciplinary)
Transmission electron microscopy
Online AccessGet full text

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Abstract Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body 1 , 2 . The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an ‘energy currency’ for biological processes in cells 3 , 4 , and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism 5 . Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels of ATP and NADPH to optimum concentrations 1 , 4 , 6 – 8 . Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease. Proof of concept of the viability of a plant-derived photosynthetic system based on nanothylakoid units encapsulated in a chondrocyte membrane to enhance cell anabolism in chondrocytes is demonstrated.
AbstractList Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body1,2. The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an 'energy currency' for biological processes in cells3,4, and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism5. Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels ofATP and NADPH to optimum concentrations1,4,6-8. Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease.
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body 1 , 2 . The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an ‘energy currency’ for biological processes in cells 3 , 4 , and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism 5 . Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels of ATP and NADPH to optimum concentrations 1 , 4 , 6 – 8 . Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease. Proof of concept of the viability of a plant-derived photosynthetic system based on nanothylakoid units encapsulated in a chondrocyte membrane to enhance cell anabolism in chondrocytes is demonstrated.
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body 1,2 . The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an ‘energy currency’ for biological processes in cells 3,4 , and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism 5 . Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels of ATP and NADPH to optimum concentrations 1,4,6–8 . Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease.
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body1,2. The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an 'energy currency' for biological processes in cells3,4, and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism5. Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels of ATP and NADPH to optimum concentrations1,4,6-8. Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease.Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body1,2. The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an 'energy currency' for biological processes in cells3,4, and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism5. Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels of ATP and NADPH to optimum concentrations1,4,6-8. Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease.
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body . The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an 'energy currency' for biological processes in cells , and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism . Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels of ATP and NADPH to optimum concentrations . Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease.
Author Liu, Zhaoming
Fan, Shunwu
Chen, Pengfei
Song, Nan
Gu, Chenhui
Dai, Zhanqiu
Lin, Xianfeng
Zhang, Jianfeng
Fang, Xiangqian
Liu, Xin
Zhong, Peiyu
Tang, Ruikang
Li, Mobai
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  givenname: Xin
  orcidid: 0000-0002-2339-3973
  surname: Liu
  fullname: Liu, Xin
  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
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  givenname: Chenhui
  orcidid: 0000-0002-8698-9395
  surname: Gu
  fullname: Gu, Chenhui
  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
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  surname: Zhong
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  givenname: Nan
  surname: Song
  fullname: Song, Nan
  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
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  surname: Li
  fullname: Li, Mobai
  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
– sequence: 7
  givenname: Zhanqiu
  surname: Dai
  fullname: Dai, Zhanqiu
  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
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  surname: Fang
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  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
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  fullname: Liu, Zhaoming
  organization: Department of Chemistry, Zhejiang University
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  givenname: Jianfeng
  surname: Zhang
  fullname: Zhang, Jianfeng
  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
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  orcidid: 0000-0001-5277-7338
  surname: Tang
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  email: rtang@zju.edu.cn
  organization: Department of Chemistry, Zhejiang University
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  givenname: Shunwu
  orcidid: 0000-0003-3443-4395
  surname: Fan
  fullname: Fan, Shunwu
  email: shunwu_fan@zju.edu.cn
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  email: xianfeng_lin@zju.edu.cn
  organization: Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36477541$$D View this record in MEDLINE/PubMed
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SSID ssj0005174
Score 2.668233
Snippet Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body 1 , 2 . The anabolism of intracellular substances...
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body 1,2 . The anabolism of intracellular substances...
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body . The anabolism of intracellular substances...
Insufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body1,2. The anabolism of intracellular substances...
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StartPage 546
SubjectTerms 13/31
13/51
14/19
14/28
14/34
38/91
631/61/490
631/61/54/2295
64/60
Adenosine Triphosphate - metabolism
Arthritis
Biological activity
Biomaterials
Biomedical materials
Cartilage
Cartilage - cytology
Cartilage - metabolism
Cartilage diseases
Cell membranes
Chondrocytes
Chondrocytes - metabolism
Controllability
Disease
Energy
Energy Metabolism
Homeostasis
Humanities and Social Sciences
Humans
Intracellular
Light
Medical treatment
Membrane Fusion
Membranes
Metabolism
multidisciplinary
NADP - metabolism
Nanoparticles
Osteoarthritis
Osteoarthritis - metabolism
Osteoarthritis - pathology
Osteoarthritis - therapy
Particle size
Photosynthesis
Plants
Plants - metabolism
Proteins
Proteomics
Science
Science (multidisciplinary)
Transmission electron microscopy
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Title A plant-derived natural photosynthetic system for improving cell anabolism
URI https://link.springer.com/article/10.1038/s41586-022-05499-y
https://www.ncbi.nlm.nih.gov/pubmed/36477541
https://www.proquest.com/docview/2755622115
https://www.proquest.com/docview/2753316609
https://pubmed.ncbi.nlm.nih.gov/PMC9750875
Volume 612
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