Exploration of the Molecular Basis of Forsythia Fruit in the Prevention and Treatment of Cholestatic Liver Injury through Network Pharmacology and Molecular Docking

• Published in: Nutrients Vol. 15; no. 9; p. 2065
• Main Authors: Fu, Ke, Li, Yanzhi, Dai, Shu, Li, Yunxia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2023; MDPI
• Subjects: Animals; Apoptosis; Bile ducts; Cancer; Cholangitis; Cholestasis; Cholestasis - drug therapy; Collagen; Disease prevention; Drugs; Extracellular matrix; Fibrosis; Forsythia; forsythia fruit; forsythoside A; Fruit; Fruits; Functional foods; Functional foods & nutraceuticals; Gallbladder diseases; Gelatinase A; Herbal medicine; Inflammation; Injury prevention; Ligands; Liver; Liver diseases; Metabolites; Mice; Molecular docking; Molecular Docking Simulation; MyD88 protein; Network Pharmacology; NF-kappa B; NF-κB protein; Pharmacology; Pruritus; Software; Synaptotagmin; TLR4 protein; TLR4/NF-κB pathway; Toll-Like Receptor 4 - genetics; Toll-like receptors; forsythia fruit; molecular docking; forsythoside A; TLR4/NF-κB pathway; cholestasis; network pharmacology

Forsythia fruit, edible fruit of (Thunb.) Vahl, which has been found to be effective in treating cholestasis. However, its key component for alleviating cholestasis has not been determined. In this study, four representative active ingredients in forsythia fruit were selected. Through network pharma...