Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts

• Published in: Nature communications Vol. 14; no. 1; p. 906
• Main Authors: Ng, Pei Ying, Ribet, Amy B. P., Guo, Qiang, Mullin, Benjamin H., Tan, Jamie W. Y., Landao-Bassonga, Euphemie, Stephens, Sébastien, Chen, Kai, Yuan, Jinbo, Abudulai, Laila, Bollen, Maike, Nguyen, Edward T. T. T., Kular, Jasreen, Papadimitriou, John M., Søe, Kent, Teasdale, Rohan D., Xu, Jiake, Parton, Robert G., Takayanagi, Hiroshi, Pavlos, Nathan J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.02.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/109; 14; 38; 38/35; 45; 45/43; 631/136/815/817; 631/443/63; 631/80/313/1624; 631/80/642/1624; 64/60; 692/163/2743/316/800; 82/58; Animals; Biological Transport; Bone and Bones - metabolism; Bone diseases; Bone mass; Bone Resorption - metabolism; Bone turnover; Cathepsin K; Cell Membrane - metabolism; Chemical composition; Digestion; Humanities and Social Sciences; Lysosomes; Lysosomes - metabolism; Membranes; Metabolism; Mice; Monosaccharides; multidisciplinary; Organelles; Osteoclasts; Osteoclasts - metabolism; Proteomics; Science; Science (multidisciplinary); Sugar; Therapeutic targets

Osteoclasts are giant bone-digesting cells that harbor specialized lysosome-related organelles termed secretory lysosomes (SLs). SLs store cathepsin K and serve as a membrane precursor to the ruffled border, the osteoclast’s ‘resorptive apparatus’. Yet, the molecular composition and spatiotemporal o...